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67results about How to "Minimizing penetration" patented technology

Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses

InactiveUS20080317679A1Efficient deliveryMinimizing systemic penetrationOrganic active ingredientsBiocideActive agentNitric oxide
The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising:
    • i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof;
    • ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof;
    • iii. a surface-active agent;
    • iv. about 0% to about 5% by weight of at least one polymeric agent; and
    • v. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition;
    • wherein the composition is housed in a container and is substantially flowable, and
    • which upon release expands to form a breakable foam; and
    • wherein the foamable carrier is selected to generate a foam of good to excellent quality.
The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
Owner:FOAMIX PHARMACEUTICALS LIMITED

Foamable Compositions and Kits Comprising One or More of a Channel Agent, a Cholinergic Agent, A nitric Oxide Donor and Related Agents and Their Uses

The present invention relates to a foamable therapeutic composition comprising: (a) a therapeutically effective concentration of at least one active agent selected from the group consisting of a channel agent, a cholinergic agent, and a nitric oxide donor; and (b) a foamable carrier comprising:i. about 50% to about 98% of a solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, and mixtures thereof;ii. 0% to about 48% of a secondary solvent selected from the group consisting of water; a hydrophilic solvent; a hydrophobic solvent; a potent solvent; a polar solvent, a silicone, an emollient, a co-solvent, a penetration enhancer and mixtures thereof;iii. a surface-active agent;iv. about 0% to about 5% by weight of at least one polymeric agent; andv. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition;wherein the composition is housed in a container and is substantially flowable, andwhich upon release expands to form a breakable foam; andwherein the foamable carrier is selected to generate a foam of good to excellent quality.The invention further provides a method of treating, alleviating or preventing a disorder of mammalian subject, comprising administering such a composition to an afflicted target site.
Owner:FOAMIX PHARMACEUTICALS LIMITED

Customized electronic display and methods of customizing the physical size and/or shape thereof

Electronic displays are physically reshaped and / or resized to meet custom specifications for special applications such as avionics, where Commercial Off-The-Shelf (COTS) Liquid Crystal Displays (LCDs) are not typically used. Customization includes cutting the physical display to specified dimensions to fit into a target opening, and resealing the display to preserve proper cell spacing and assure basic functionality. The target opening is typically a control panel or dashboard opening, such as in the cockpit of an airplane. The sealing process may include improving the original seal, and / or providing additional seals. Additional seals may protect sensitive areas against chemical corrosives or contamination, humidity, electrostatic damage, etc., and / or prevent light from passing around the edge of the display image area. Electric continuity may need to be reestablished for electric leads affected during the customization process, and electronic drivers may need to be reattached to the display. Additional modifications and / or enhancements may be made to the display during reshaping and / or resizing. For example, TABs or COGs may be relocated, added, removed, replaced, and / or reoriented; electric circuits may be replaced and / or supplemented with circuits having different functionality; the display medium may be altered and / or replaced; polarizers, filters, and / or films may be added, removed, and / or replaced. The customized display may then be ruggedized by attaching a suitable bezel (face plate) and frame (support hardware) thereto, and the completed, customized display unit may then be installed in the target location and integrated with surrounding hardware and electronics.
Owner:PIXEL SCI
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