Ultrasonic thrombolysis catheter

Abstract

The utility model provides an ultrasonic thrombolysis catheter. The ultrasonic thrombolysis catheter comprises an infusion basket, a driving mechanism and an ultrasonic assembly. The infusion basket comprises a plurality of infusion catheters, and a hollow structure is defined by the infusion catheters. The driving mechanism is used for controlling the infusion basket to expand and open or close in the radial direction. The ultrasonic assembly comprises a plurality of ultrasonic electrodes, and the ultrasonic electrodes are fixed in the hollow structure of the infusion basket. During use, the infusion basket which is initially in a closed state is conveyed to a lesion position, and the infusion basket is expanded and opened through the driving mechanism, so that blood flows through thrombus. Thrombolysis medicine enters each infusion catheter and is conveyed to diseased tissue through the infusion holes in the infusion catheters, the thrombolysis medicine is accurately released to thrombus, accurate thrombolysis is achieved, and the dosage of the thrombolysis medicine is reduced. Meanwhile, the ultrasonic electrode is communicated with an ultrasonic generator, so that the ultrasonic generator generates ultrasonic waves, and the ultrasonic waves accelerate point dissolution by unfastening and diluting a fibrin chain, so that more drug receptor sites are exposed.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and particularly relates to an ultrasonic thrombolysis catheter. Background Art

[0002] Pulmonary embolism has become the third leading cause of death from cardiovascular disease worldwide, second only to myocardial infarction and stroke. Anticoagulation and systemic thrombolysis are Class I treatment strategies recommended by the guidelines, but both have defects: anticoagulation alone cannot quickly reduce the burden of pulmonary thrombus and improve right ventricular function, and patients have longer hospital stays and a high recurrence rate; while systemic thrombolysis greatly increases the risk of bleeding, so its application is limited.

[0003] Catheter directed treatment (CDT) can directly inject drugs into the pulmonary artery to obtain a higher local thrombolytic concentration, which can not only quickly improve the patient's condition but also reduce the occurrence of bleeding. It has great application potential in the treatment of pulmonary embolism. Compared with anticoagulation and systemic thrombolysis alone, CDT can better improve the long-term quality of life of patients with moderate-risk pulmonary embolism.

[0004] Therefore, how to deliver specific drugs in a targeted manner, reduce the dosage of thrombolytic drugs, and at the same time enable the drugs to achieve efficient and rapid thrombolysis is an urgent problem to be solved by those skilled in the art. Utility Model Content

[0005] The utility model aims to provide an ultrasonic thrombolytic catheter, which can deliver designated drugs in a targeted manner, reduce the dosage of thrombolytic drugs, and at the same time can promote the drugs to achieve efficient and rapid thrombolysis.

[0006] In order to solve the above technical problems, the utility model provides an ultrasonic thrombolytic catheter, comprising: an infusion basket, a driving mechanism and an ultrasonic component;

[0007] The infusion basket comprises a plurality of infusion catheters, the plurality of infusion catheters enclose a hollow structure, the proximal end of each of the infusion catheters is used to inject thrombolytic drugs, and each of the infusion catheters is provided with a plurality of infusion holes;

[0008] The driving mechanism is used to control the infusion basket to expand and open or to retract and close in the radial direction;

[0009] The ultrasonic assembly includes a plurality of ultrasonic electrodes, the plurality of ultrasonic electrodes are fixed inside the hollow structure of the infusion basket, and the plurality of ultrasonic electrodes are connected to an ultrasonic generator via electrical conductors.

[0010] Optionally, in the above ultrasonic thrombolysis catheter, it further comprises: a handle, an outer lumen tube, an inner lumen tube, a transition tube and a terminal tube;

[0011] The handle is provided with a guide wire outlet, an infusion basket injection interface and an ultrasonic generator connection port;

[0012] The outer lumen is provided with a guide wire lumen and an infusion basket infusion lumen, and the proximal end of the infusion basket infusion lumen of the outer lumen is communicated with the infusion basket injection interface;

[0013] The transition tube has an inner cavity, and the proximal end of the transition tube is connected to the distal end of the outer cavity tube;

[0014] The inner lumen tube is provided with a guidewire cavity, the distal end of the inner lumen tube is fixed to the terminal tube, the proximal end of the inner lumen tube sequentially passes through the inner lumen of the transition tube and the guidewire cavity of the outer lumen tube, and the guidewire cavity of the inner lumen tube is communicated with the guidewire outlet on the handle;

[0015] The distal end of each of the infusion catheters is fixed to the terminal tube, the proximal end is connected to the transition tube and communicates with the distal end of the infusion cavity of the infusion basket of the outer cavity tube;

[0016] Wherein, one end of the electric wire is connected to the ultrasonic generator, and the other end passes through the ultrasonic generator connection port, the guide wire cavity of the outer cavity tube, and is connected to each of the ultrasonic electrodes in sequence;

[0017] The driving mechanism is used to drive the inner cavity tube and the handle to move relative to each other, so as to control the infusion basket to expand and open or to retract and close in the radial direction;

[0018] The thrombolytic drug is injected through the injection interface of the infusion basket, enters each of the infusion catheters through the infusion cavity of the infusion basket of the outer cavity tube, and is transported to the diseased tissue through each of the infusion holes.

[0019] Optionally, in the above-mentioned ultrasonic thrombolysis catheter, an ultrasonic balloon filling interface is also provided on the handle, an ultrasonic balloon is provided on the outside of the inner lumen tube, and the inner lumen tube is also provided with an ultrasonic balloon filling cavity, the ultrasonic balloon is connected to the distal end of the ultrasonic balloon filling cavity of the inner lumen tube, and the proximal end of the ultrasonic balloon filling cavity is connected to the ultrasonic balloon filling interface.

[0020] Optionally, in the above-mentioned ultrasonic thrombolysis catheter, a plurality of ultrasonic electrodes are fixed at intervals on the outer surface of the inner cavity tube, each of the ultrasonic electrodes is wrapped with an insulating layer, and the ultrasonic balloon is located outside the ultrasonic electrode.

[0021] Optionally, in the above-mentioned ultrasonic thrombolysis catheter, a drug delivery cavity outlet is further provided on the handle, a drug delivery cavity is further provided on the outer cavity tube, the proximal end of the drug delivery cavity is connected to the drug delivery cavity outlet of the handle, and a through hole for connecting the outside world and the drug delivery cavity is provided on the distal end of the outer cavity tube.

[0022] Optionally, in the above-mentioned ultrasonic thrombolysis catheter, the driving mechanism is a control switch, the control switch is slidably connected to the handle, and the control switch is also connected to the proximal end of the inner cavity tube.

[0023] Optionally, in the above ultrasonic thrombolysis catheter, a strip groove is provided on the handle along the operation direction, and the control switch is a slider slidably connected to the strip groove.

[0024] Optionally, in the above-mentioned ultrasonic thrombolysis catheter, the guidewire outlet on the handle, the inner cavity of the transition tube, the outer cavity tube and the guidewire cavity of the inner cavity tube are coaxially arranged.

[0025] Optionally, in the above-mentioned ultrasonic thrombolysis catheter, the multiple infusion catheters are independent of each other and arranged at intervals, or the multiple infusion catheters form a network structure.

[0026] Optionally, in the above-mentioned ultrasonic thrombolysis catheter, the infusion catheter is a catheter made of polyimide, polytetrafluoroethylene, expanded polytetrafluoroethylene, polyvinylidene fluoride, high-density polyethylene, nylon 6, nylon elastomer or nylon;

[0027] Alternatively, the infusion catheter is a catheter made of stainless steel, shape memory metal or woven polymer fibers.

[0028] The utility model provides an ultrasonic thrombolytic catheter, which has the following beneficial effects:

[0029] When in use, the infusion basket, which is initially in a closed state, is transported to the lesion site, and the infusion basket is expanded and opened by a driving mechanism. Under the action of the expansion of the infusion basket, a central channel is formed in the center of the infusion basket, allowing blood to flow through the thrombus site. The thrombolytic drug enters each infusion catheter and is transported to the lesion tissue through the infusion hole on the infusion catheter, and the thrombolytic drug is accurately released to the thrombus to achieve the effect of precise thrombolysis. Since a large amount of thrombolytic drugs are released at the thrombus site, the dosage of thrombolytic drugs can be reduced. At the same time, the ultrasonic electrode is connected to the ultrasonic generator to generate ultrasound, which accelerates point dissolution by untying and diluting the fibrin chain, thereby exposing more drug receptor sites, further exerting the thrombolytic effect, and improving the thrombolytic efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0031] Figure 1A schematic diagram of the structure of an ultrasonic thrombolytic catheter in a retracted and closed state provided by an embodiment of the utility model;

[0032] Figure 2 A schematic diagram of the structure of an ultrasonic thrombolytic catheter in an expanded and open state provided by an embodiment of the utility model;

[0033] Figure 3 A schematic diagram of the structure of the infusion basket provided by an embodiment of the utility model in a folded and closed state;

[0034] Figure 4 A schematic diagram of the structure of the infusion basket provided by an embodiment of the utility model in an expanded and open state;

[0035] Figure 5 A schematic cross-sectional view of an outer lumen tube provided in an embodiment of the utility model;

[0036] Figure 6 A schematic diagram of the structure of an ultrasonic thrombolytic catheter in a retracted and closed state provided by another embodiment of the utility model;

[0037] Figure 7 A schematic diagram of the structure of an ultrasonic thrombolytic catheter in an expanded and open state provided by another embodiment of the utility model;

[0038] Figure 8 A schematic cross-sectional view of an outer lumen tube provided in another embodiment of the utility model;

[0039] Fig. 9 This is a schematic structural diagram of a handle provided in another embodiment of the utility model.

[0040] In the above picture:

[0041] 1-terminal tube; 2-inner cavity tube; 3-ultrasonic component; 4-ultrasonic electrode; 5-infusion catheter; 6-electric conductor; 7-through hole; 8-ultrasonic balloon filling cavity; 9-infusion basket injection interface; 10-ultrasonic generator connection port; 11-ultrasonic balloon filling interface; 12-control switch; 13-drug delivery cavity outlet; 14-guide wire outlet; 15-transition tube; 16-infusion basket infusion cavity; 17-drug delivery cavity; 18-guide wire cavity; 19-outer cavity tube. DETAILED DESCRIPTION

[0042] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0043] The core of the utility model is to provide an ultrasonic thrombolytic catheter, which can deliver designated drugs in a targeted manner, reduce the dosage of thrombolytic drugs, and at the same time can promote the drugs to complete efficient and rapid thrombolysis.

[0044] In order to enable those skilled in the art to better understand the technical solution provided by the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0045] Specifically, please refer to Figure 1-Figure 9 The embodiment of the utility model discloses an ultrasonic thrombolytic catheter, which includes an infusion basket, a driving mechanism and an ultrasonic component 3.

[0046] The infusion basket includes a plurality of infusion catheters 5, which form a hollow structure. That is, when the infusion basket is folded and closed, each infusion catheter 5 is arranged around the hollow structure. The diameter of the hollow structure should not be too large, so that the outer size of the infusion basket in the folded and closed state can be easily delivered to the diseased position of the blood vessel.

[0047] Figure 4 In the illustrated solution, the number of infusion catheters 5 is 6. Of course, other numbers of infusion catheters 5 can be selected according to actual conditions, and are not limited to Figure 4 The quantity shown in .

[0048] The proximal end of each infusion catheter 5 is used to inject thrombolytic drugs. Each infusion catheter 5 is provided with a plurality of infusion holes, through which the thrombolytic drugs are delivered to the diseased tissue. The number and density of the infusion holes on the infusion catheter 5 can be designed according to demand.

[0049] The driving mechanism is used to control the infusion basket to expand and open or to retract and close in the radial direction. The driving mechanism can be arranged at the proximal end of the ultrasonic thrombolysis catheter to facilitate the operator to operate the driving mechanism and control the infusion basket at the distal end of the ultrasonic thrombolysis catheter to switch between an expanded open state or a retracted closed state. When the infusion basket is expanded and opened, each infusion catheter 5 expands radially outward to close to the blood vessel wall and release the thrombolytic drug through the infusion hole.

[0050] The ultrasonic assembly 3 includes a plurality of ultrasonic electrodes 4, which are fixed inside the hollow structure of the infusion basket and connected to the ultrasonic generator through the electrical conductor 6. Since the ultrasonic electrodes 4 are fixed inside the hollow structure of the infusion basket, when the infusion basket is transported to the lesion site by the ultrasonic thrombolysis catheter, the ultrasonic electrodes 4 are also transported to the lesion site of the blood vessel, thereby improving the efficiency of interventional treatment.

[0051] Under the action of the ultrasonic generator, each ultrasonic electrode 4 generates an acoustic field, and the ultrasonic wave significantly improves the efficiency of thrombolysis by driving the drug deeper into the clot and unfolding the fibrin to expose the plasminogen receptor site.

[0052] It should be noted that the “proximal end” and “distal end” mentioned in this article are near and far relative to the operator, the end close to the operator is the “proximal end”, and the end far from the operator is the “distal end”.

[0053] It should also be noted that the infusion basket creates multiple infusion channels (i.e., multiple infusion channels are formed by multiple infusion catheters 5), which are used for catheter-guided thrombolysis (CDT) to treat large blood clots in blood vessels, and achieves precise thrombolysis and reduces side effects by accurately releasing thrombolytic drugs to the thrombus. When the multiple infusion catheters 5 are expanded, a large central channel is immediately formed to allow blood to flow through the thrombus site. A series of cross-sectional channels are formed in the occluded thrombus, allowing the patient's own blood flow and endogenous hemolytic agents to dissolve the thrombus. Taking an example with 6 infusion catheters 5, each of which has 8 infusion holes, the thrombus can be saturated through the infusion catheter 5 with 48 infusion holes to synergistically improve the efficiency of the treatment.

[0054] In summary, the ultrasonic thrombolytic catheter disclosed in the embodiment of the utility model, when in use, delivers the infusion basket that is initially in a closed state to the lesion site, expands and opens the infusion basket through a driving mechanism, and forms a central channel in the center of the infusion basket under the action of the expansion of the infusion basket, allowing blood to flow through the thrombus site. The thrombolytic drug enters each infusion catheter 5, and is delivered to the lesion tissue through the infusion hole on the infusion catheter 5, and the thrombolytic drug is accurately released to the thrombus site to achieve the effect of accurate thrombolysis. Since the thrombolytic drug is released in large quantities at the thrombus site, the dosage of the thrombolytic drug can be reduced. At the same time, the ultrasonic electrode 4 is connected to the ultrasonic generator to generate ultrasound, which accelerates point dissolution by untying and diluting the fibrin chain, thereby exposing more drug receptor sites, further exerting the thrombolytic effect, and improving the thrombolytic efficiency.

[0055] Furthermore, the ultrasonic thrombolytic catheter disclosed in the embodiment of the utility model may also include: a handle, an outer lumen 19, an inner lumen 2, a transition tube 15 and a terminal tube 1. The handle, the outer lumen 19, the transition tube 15, the infusion basket and the terminal tube 1 are arranged in sequence from near to far.

[0056] The handle is provided with a guidewire outlet 14, an infusion basket injection interface 9 and an ultrasonic generator connection port 10. The outer lumen 19 is provided with a guidewire cavity 18 and an infusion basket infusion cavity 16, and the proximal end of the infusion basket infusion cavity 16 of the outer lumen 19 is connected to the infusion basket injection interface 9. In this embodiment, the number of infusion holes of each infusion catheter 5 is 8, and the infusion holes can be formed by laser drilling. The thrombolytic drug is injected through the infusion basket injection interface 9, enters each infusion catheter 5 through the infusion basket infusion cavity 16, and is delivered to the diseased tissue through each infusion hole. It should be noted that the number of infusion holes of each infusion catheter 5 is not limited to 8, and those skilled in the art can select the number of infusion holes according to needs. At the same time, the number of infusion holes of each infusion catheter 5 can be the same or different.

[0057] The transition tube 15 has an inner cavity, and the proximal end of the transition tube 15 is connected to the distal end of the outer cavity tube 19. A guidewire cavity is provided on the inner cavity tube 2, the distal end of the inner cavity tube 2 is fixed to the terminal tube 1, and the proximal end passes through the inner cavity of the transition tube 15 and the guidewire cavity 18 of the outer cavity tube 19 in sequence, and the guidewire cavity of the inner cavity tube 2 is connected to the guidewire outlet 14 on the handle.

[0058] The distal end of each infusion catheter 5 is fixed to the terminal tube 1, and the proximal end is connected to the transition tube 15 and communicated with the distal end of the infusion cavity 16 of the infusion basket of the outer cavity tube 19. The transition tube 15 is fixed relative to the outer cavity tube 19 and the handle, so that the proximal end of the infusion catheter 5 is also fixed relative to the handle, and the distal end of the infusion catheter 5 is fixed to the terminal tube 1, and the distal end of the inner cavity tube 2 is fixed to the terminal tube 1, so the position of the distal end of the infusion catheter 5 can be changed by changing the position of the inner cavity tube 2, and because the position of the proximal end of the infusion catheter 5 is fixed, the infusion basket can be controlled to expand and open or retract and close in the radial direction according to the moving direction of the distal end of the infusion catheter 5. For example, when the distal end of the infusion catheter 5 moves in a direction close to the proximal end, the infusion basket expands and opens in the radial direction, and when the distal end of the infusion catheter 5 moves in a direction away from the proximal end, the infusion basket retracts and closes in the radial direction.

[0059] One end of the electric wire 6 is connected to the ultrasonic generator, and the other end passes through the ultrasonic generator connection port 10 and the guide wire cavity 18 of the outer cavity tube 19 in sequence, and is connected to each ultrasonic electrode 4 .

[0060] The driving mechanism is used to drive the inner tube 2 and the handle to move relative to each other, so as to control the infusion basket to expand and open or to retract and close in the radial direction. Specifically, the driving mechanism can drive the inner tube 2 and the terminal tube 1 (relative to the handle) to move proximally, so as to control the infusion basket to expand and open in the radial direction. The driving mechanism drives the inner tube 2 and the terminal tube 1 (relative to the handle) to move distally, so as to control the infusion basket to retract and close in the radial direction.

[0061] The thrombolytic drug is injected through the infusion basket injection port 9, enters each infusion catheter 5 through the infusion basket infusion cavity 16 of the outer cavity tube 19, and is transported to the diseased tissue through each infusion hole.

[0062] In a further specific implementation, an ultrasonic balloon filling interface 11 is further provided on the handle. An ultrasonic balloon is provided on the outside of the inner cavity tube 2, and the inner cavity tube 2 is also provided with an ultrasonic balloon filling cavity 8, the ultrasonic balloon is connected to the distal end of the ultrasonic balloon filling cavity 8 of the inner cavity tube 2, and the proximal end of the ultrasonic balloon filling cavity 8 is connected to the ultrasonic balloon filling interface 11.

[0063] Preferably, a plurality of ultrasound electrodes 4 are fixed at intervals on the outer surface of the inner cavity tube 2, each ultrasound electrode 4 is wrapped with an insulating layer, and the ultrasound balloon is located outside the ultrasound electrode 4. In this embodiment, a plurality of ultrasound electrodes 4 are provided, and each ultrasound electrode 4 is arranged at intervals to expand the coverage of the ultrasound electrode 4 and improve the ultrasound range to adapt to a larger lesion area.

[0064] Furthermore, a drug delivery cavity outlet 13 is provided on the handle, and a drug delivery cavity 17 is also provided on the outer cavity tube 19. The proximal end of the drug delivery cavity 17 is connected to the drug delivery cavity outlet 13 of the handle, and a through hole 7 for connecting the outside world and the drug delivery cavity 17 is provided on the distal end of the outer cavity tube 19.

[0065] When in use, the infusion basket is initially in a closed state and is delivered to the lesion site, and the infusion basket is controlled to expand and open. The thrombolytic drug is injected through the infusion basket injection port 9, enters each infusion catheter 5 through the infusion basket infusion cavity 16, and is delivered to the lesion tissue through the infusion hole. At the same time, the drug can be injected through the drug delivery cavity outlet 13, delivered to the through hole 7 of the outer cavity tube 19 through the drug delivery cavity 17, and released to the lesion tissue through the through hole 7. The ultrasonic balloon is filled, and the ultrasonic electrode 4 is connected to the ultrasonic transmitter to generate ultrasound. Ultrasound accelerates point dissolution by untying and diluting the fibrin chain, thereby exposing more drug receptor sites. The acoustic wave flow drives the drug into deeper points for safe dissolution, thereby significantly improving the efficiency of thrombolysis.

[0066] It should be noted that the drug injected from the drug delivery cavity outlet 13 may be the same as or different from the drug injected from the infusion basket injection port 9, so that the specified thrombolytic drug can be accurately released.

[0067] In a specific embodiment, the driving mechanism is a control switch 12 , and the control switch 12 is slidably connected to the handle. The control switch 12 is also connected to the proximal end of the inner cavity tube 2 .

[0068] The control switch 12 moves relative to the handle, and can drive the inner tube 2 and the terminal tube 1 to move, and then control the distance between the distal end and the proximal end of the infusion basket. When the distance between the distal end and the proximal end of the infusion basket becomes smaller, the infusion basket can be controlled to expand and open in the radial direction. When the distance between the distal end and the proximal end of the infusion basket becomes larger, the infusion basket can be controlled to retract and close in the radial direction. Specifically, the control switch 12 moves proximally relative to the handle, and can drive the inner tube 2 and the terminal tube 1 to move proximally to control the infusion basket to expand and open in the radial direction. The control switch 12 moves distally relative to the handle, and can drive the inner tube 2 and the terminal tube 1 to move distally to control the infusion basket to retract and close in the radial direction.

[0069] The ultrasonic thrombolytic catheter disclosed in the embodiment of the utility model, when in use, delivers the infusion basket which is initially in a closed state to the lesion position, pushes the control switch 12 on the handle, drives the inner cavity tube 2 and the terminal tube 1 to move toward the proximal end, and thus expands and opens the infusion basket. The thrombolytic drug is injected through the infusion basket injection interface 9 on the handle, enters each infusion catheter 5 through the infusion basket infusion cavity 16 on the outer cavity tube 19, and is delivered to the lesion tissue through the infusion hole on the infusion catheter 5.

[0070] In addition, when the multiple infusion catheters 5 of the infusion basket expand, a large central channel is immediately formed, allowing blood to flow through the thrombus site, and can deliver designated drugs in a targeted manner, achieve accurate thrombolysis, reduce the dosage of thrombolytic drugs, and at the same time promote the drug to complete efficient and rapid thrombolysis. At the same time, the filling medium (gas or liquid to fill the balloon) can be injected through the ultrasonic balloon filling interface 11, and flow to the ultrasonic balloon through the ultrasonic balloon filling cavity 8 to fill the ultrasonic balloon. The ultrasonic electrode 4 is connected to the ultrasonic generator to generate ultrasound, which accelerates point dissolution by untying and diluting the fibrin chain, thereby exposing more drug receptor sites. The acoustic wave flow drives the drug into deeper points for safe dissolution, thereby significantly improving the efficiency of thrombolysis.

[0071] In order to arrange the interfaces on the handle more reasonably, the guidewire outlet 14 on the handle, the inner cavity of the transition tube 15, the outer cavity tube 19 and the guidewire cavity of the inner cavity tube 2 are coaxially arranged to facilitate the insertion of the guidewire. The infusion basket injection interface 9, the ultrasonic generator connection port 10, the ultrasonic balloon filling interface 11 and the drug delivery cavity outlet 13 are respectively located on both sides of the handle.

[0072] The control switch 12 can be in various forms. In one form, a strip groove is provided on the handle along the operation direction, and the control switch 12 is a slider slidably connected to the strip groove. The slider is provided with anti-slip grooves to increase friction and prevent slipping. The strip groove provides a guide for the sliding of the control switch 12 to constrain the sliding direction of the control switch 12. Specifically, the extension direction of the strip groove is parallel to the axial direction of the outer cavity tube 19.

[0073] In addition, the control switch 12 can also control the diameter of the infusion basket to expand and open to adapt to the size of the blood vessel lumen diameter. That is, under the control of the control switch 12, the infusion basket is not limited to the two extreme states of expansion and opening and contraction and closure, but can also stay in a position between expansion and opening and contraction and closure to control the opening diameter to adapt to the size of the blood vessel lumen diameter.

[0074] Exemplarily, in the folded and closed state, the length of the infusion basket can be between 9cm-13cm, preferably 10cm or 12.5cm, and the width can be between 2mm-3mm, preferably 2.3mm; in the expanded and open state, the length of the infusion basket can be between 7cm-11cm, preferably 7.5cm or 10cm, and the width can be between 38mm-48mm, preferably 39mm or 45mm. It should be noted that the above dimensions are only exemplary, and those skilled in the art can set the dimensions of the infusion basket according to needs.

[0075] The infusion catheter 5 can be made of any suitable material known to ordinary technicians in the field, including but not limited to polyimide, polytetrafluoroethylene (PTFE), expanded polytetrafluoroethylene (ePTFE), polyvinylidene fluoride (PDVF), high-density polyethylene (HDPE), nylon 6 (also called polyamide-6, PA6, polyamide 6), nylon elastomer or nylon material catheter.

[0076] The infusion catheter 5 can also be made of stainless steel, shape memory metal or polymer fiber braided catheter. The catheters made of the above materials can be bent and deformed when moving in the operation direction to achieve the effect of expansion and opening or contraction and closure.

[0077] In a specific embodiment, Figure 4 As shown, the multiple infusion catheters 5 can be designed to be independent and spaced apart from each other. Of course, the multiple infusion catheters can also be designed to be a mesh structure or other shapes. The infusion catheter 5 is made of soft material and can be adjusted to bend to fit blood vessels of different thicknesses.

[0078] The infusion hole on the infusion catheter 5 can be formed by laser drilling or by other methods. The forming method of the infusion hole is not limited in this embodiment.

[0079] In the description of the present application, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0080] As shown in this application and claims, unless the context clearly indicates an exception, the words "a", "an", "a kind" and / or "the" do not refer to the singular, but also include the plural. Generally speaking, the terms "include" and "comprise" only indicate the inclusion of clearly identified steps and elements, and these steps and elements do not constitute an exclusive list. The method or device may also include other steps or elements. The elements defined by the sentence "includes a..." do not exclude the existence of other identical elements in the process, method, commodity or device that includes the elements.

[0081] In the description of the embodiments of the present application, unless otherwise specified, " / " means or, for example, A / B can mean A or B; "and / or" in this article is only a description of the association relationship of associated objects, indicating that there can be three relationships, for example, A and / or B can mean: A exists alone, A and B exist at the same time, and B exists alone. In addition, in the description of the embodiments of the present application, "multiple" means two or more than two.

[0082] In the description of this application, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in this application based on the specific content of the technical solution.

[0083] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0084] This article uses specific examples to illustrate the principles and implementation methods of the utility model. The above examples are only used to help understand the method and core ideas of the utility model. It should be pointed out that for ordinary technicians in this technical field, without departing from the principles of the utility model, the utility model can also be improved and modified, and these improvements and modifications also fall within the scope of protection of the claims of the utility model.

Claims

1. An ultrasonic thrombolytic catheter, characterized in that: include: Infusion basket, drive mechanism and ultrasonic assembly (3); The infusion basket comprises a plurality of infusion catheters (5), the plurality of infusion catheters (5) enclose a hollow structure, the proximal end of each of the infusion catheters (5) is used for injecting thrombolytic drugs, and each of the infusion catheters (5) is provided with a plurality of infusion holes; The driving mechanism is used to control the infusion basket to expand and open or to retract and close in the radial direction; The ultrasonic component (3) comprises a plurality of ultrasonic electrodes (4), wherein the plurality of ultrasonic electrodes (4) are fixed inside the hollow structure of the infusion basket, and the plurality of ultrasonic electrodes (4) are connected to an ultrasonic generator via an electrical conductor (6).

2. The ultrasonic thrombolytic catheter according to claim 1, characterized in that: It also includes a handle, an outer lumen tube (19), an inner lumen tube (2), a transition tube (15) and a terminal tube (1); The handle is provided with a guide wire outlet (14), an infusion basket injection interface (9) and an ultrasonic generator connection port (10); The outer lumen tube (19) is provided with a guide wire lumen (18) and an infusion basket infusion lumen (16), and the proximal end of the infusion basket infusion lumen (16) of the outer lumen tube (19) is in communication with the infusion basket injection interface (9); The transition tube (15) has an inner cavity, and the proximal end of the transition tube (15) is connected to the distal end of the outer cavity tube (19); The inner lumen tube (2) is provided with a guidewire cavity (18), the distal end of the inner lumen tube (2) is fixed to the terminal tube (1), and the proximal end passes through the inner lumen of the transition tube (15) and the guidewire cavity (18) of the outer lumen tube (19) in sequence, and the guidewire cavity (18) of the inner lumen tube (2) is communicated with the guidewire outlet (14) on the handle; The distal end of each infusion catheter (5) is fixed to the terminal tube (1), the proximal end is connected to the transition tube (15) and communicates with the distal end of the infusion chamber (16) of the infusion basket of the outer chamber tube (19); One end of the electrical conductor is connected to the ultrasonic generator, and the other end passes through the ultrasonic generator connection port (10), the guide wire cavity (18) of the outer cavity tube (19) in sequence, and is connected to each of the ultrasonic electrodes (4); The driving mechanism is used to drive the inner cavity tube (2) and the handle to move relative to each other, so as to control the infusion basket to expand and open or to retract and close in the radial direction; The thrombolytic drug is injected through the infusion basket injection port (9), enters each of the infusion catheters (5) through the infusion basket infusion cavity (16) of the outer cavity tube (19), and is transported to the diseased tissue through each of the infusion holes.

3. The ultrasonic thrombolytic catheter according to claim 2, characterized in that: The handle is also provided with an ultrasonic balloon filling interface (11), the outer side of the inner cavity tube (2) is provided with an ultrasonic balloon, and the inner cavity tube (2) is also provided with an ultrasonic balloon filling cavity (8), the ultrasonic balloon is connected to the distal end of the ultrasonic balloon filling cavity (8) of the inner cavity tube (2), and the proximal end of the ultrasonic balloon filling cavity (8) is connected to the ultrasonic balloon filling interface (11).

4. The ultrasonic thrombolytic catheter according to claim 3, characterized in that: A plurality of ultrasonic electrodes (4) are fixed at intervals on the outer surface of the inner cavity tube (2), each of the ultrasonic electrodes (4) is wrapped with an insulating layer, and the ultrasonic balloon is located outside the ultrasonic electrode (4).

5. The ultrasonic thrombolytic catheter according to claim 2, characterized in that: The handle is also provided with a drug delivery cavity outlet (13), and the outer cavity tube (19) is also provided with a drug delivery cavity (17). The proximal end of the drug delivery cavity (17) is connected to the drug delivery cavity outlet (13) of the handle, and the distal end of the outer cavity tube (19) is provided with a through hole (7) for connecting the outside world and the drug delivery cavity (17).

6. The ultrasonic thrombolytic catheter according to claim 2, characterized in that: The driving mechanism is a control switch, the control switch is slidably connected to the handle, and the control switch is also connected to the proximal end of the inner cavity tube (2).

7. The ultrasonic thrombolytic catheter according to claim 6, characterized in that: A strip groove is provided on the handle along the operation direction, and the control switch is a slider slidably connected to the strip groove.

8. The ultrasonic thrombolytic catheter according to claim 2, characterized in that: The guidewire outlet (14) on the handle, the inner cavity of the transition tube (15), the outer cavity tube (19) and the guidewire cavity (18) of the inner cavity tube (2) are coaxially arranged.

9. The ultrasonic thrombolytic catheter according to claim 1, characterized in that: The multiple infusion catheters (5) are independent of each other and arranged at intervals, or the multiple infusion catheters (5) form a network structure.

10. The ultrasonic thrombolytic catheter according to claim 1, characterized in that: The infusion catheter (5) is a catheter made of polyimide, polytetrafluoroethylene, expanded polytetrafluoroethylene, polyvinylidene fluoride, high-density polyethylene, nylon 6, nylon elastomer or nylon; Alternatively, the infusion catheter (5) is a catheter made of stainless steel, shape memory metal or woven polymer fibers.

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