Lactalbumin-oleic acid compound and carrageenan composite medicine as well as preparation method and application thereof

Abstract

The invention discloses a lactalbumin-oleic acid compound and carrageenan composite medicine, which consists of 0.01-1 part by weight of a lactalbumin-oleic acid compound, 0.5-1.5 parts by weight of carrageenan, 1-3 parts by weight of carbomer, 1-5 parts by weight of glycerol and 0.1-0.2 part by weight of ethylparaben. The composite medicine is in the form of a gel, a suppository or a dressing. The composite medicine can be used for preventing and treating female human papilloma virus infection as well as for preventing and treating female gynecological gram negative bacterium infection.

Description

technical field

[0001] The invention relates to a product for gynecological diseases, in particular to a combination medicine of lactalbumin-oleic acid compound and carrageenan, its preparation method and application. Background technique

[0002] HPV widely exists in nature, and human skin, digestive tract, respiratory tract, etc. all carry HPV. All sexually active women are likely to be infected with HPV through sexual contact, and 70-80% of women will be infected with HPV at least once in their lives. Due to the complex etiology of various human cancers, it is difficult for current science and technology to effectively prevent, detect and treat them early. Cervical cancer is currently the only cause that can be determined because it is caused by HPV infection. Therefore, it is the only cancer that can be effectively prevented. Cancer that is detected in time and can be treated early. Internationally, HPV-targeted cervical cancer vaccine research is the mainstay. Some va...

Examples

Embodiment 1

[0028] Example 1: Combination Drugs

[0029] The combined medicine consists of 0.5 parts by weight of lactalbumin-oleic acid complex, 1 part by weight of carrageenan, 2 parts by weight of carbomer, 5 parts by weight of glycerin, 0.15 parts by weight of ethylparaben, 1 part by weight of ethyl paraben, Triethanolamine, the water composition of 90.35 parts by weight.

[0030] Preparation:

[0031] 1): Weigh each raw material according to the ratio, stir 2 parts of carbomer in 20 parts of water at 80°C until fully swollen, then add 1 part of carrageenan, stir until completely dissolved, and filter and sterilize through a 0.22 μm membrane while it is hot , to obtain No. 1 solution;

[0032] 2): Dissolve 0.15 parts of ethylparaben in 5 parts of water, filter and sterilize through a 0.22 μm membrane to obtain No. 2 solution;

[0033] 3): Add No. 2 solution to No. 1 solution under agitation and mix evenly, add 0.5 parts of triethanolamine, adjust the pH to 5.6, and obtain No. 3 sol...

Embodiment 2

[0037] Embodiment 2: combination medicine

[0038] The combined medicine consists of 0.01 weight part of lactalbumin-oleic acid complex, 0.5 weight part of carrageenan, 1 weight part of carbomer, 1 weight part of glycerin, 0.1 weight part of ethylparaben, 1 weight part The triethanolamine, the water composition of 96.39 parts by weight.

[0039] Preparation:

[0040] 1): Weigh each raw material according to the ratio, stir 1 part of carbomer in 20 parts of water at 85°C until fully swollen, then add 0.5 part of carrageenan, stir until completely dissolved, and filter and sterilize through a 0.22 μm membrane while it is hot , to obtain No. 1 solution;

[0041] 2): Dissolve 0.1 part of ethylparaben in 5 parts of water, filter and sterilize through a 0.22 μm membrane to obtain No. 2 solution;

[0042] 3): Add No. 2 solution to No. 1 solution under agitation and mix evenly, add 0.5 parts of triethanolamine, adjust the pH to 5.6, and obtain No. 3 solution;

[0043] 4): Dissolve...

Embodiment 3

[0046] Embodiment 3: combination medicine

[0047] The combination medicine consists of 1 weight part of lactalbumin-oleic acid complex, 1.5 weight parts of carrageenan, 3 weight parts of carbomer, 5 weight parts of glycerin, 0.2 weight parts of ethylparaben, 2 weight parts The triethanolamine, the water composition of 87.3 parts by weight.

[0048] Preparation:

[0049] 1): Weigh each raw material according to the ratio, stir 3 parts of carbomer in 20 parts of water at 85°C until fully swollen, then add 1.5 parts of carrageenan, stir until completely dissolved, and filter and sterilize through a 0.22 μm membrane while it is hot , to obtain No. 1 solution;

[0050] 2): Dissolve 0.2 parts of ethylparaben in 5 parts of water, filter and sterilize through a 0.22 μm membrane to obtain No. 2 solution;

[0051] 3): Add No. 2 solution to No. 1 solution under agitation and mix evenly, add 1 part of triethanolamine, adjust the pH to 5.6, and obtain No. 3 solution;

[0052] 4): Diss...

technical field

[0001] The invention relates to a product for gynecological diseases, in particular to a combination medicine of lactalbumin-oleic acid compound and carrageenan, its preparation method and application. Background technique

[0002] HPV widely exists in nature, and human skin, digestive tract, respiratory tract, etc. all carry HPV. All sexually active women are likely to be infected with HPV through sexual contact, and 70-80% of women will be infected with HPV at least once in their lives. Due to the complex etiology of various human cancers, it is difficult for current science and technology to effectively prevent, detect and treat them early. Cervical cancer is currently the only cause that can be determined because it is caused by HPV infection. Therefore, it is the only cancer that can be effectively prevented. Cancer that is detected in time and can be treated early. Internationally, HPV-targeted cervical cancer vaccine research is the mainstay. Some va...

Examples

Embodiment 1

[0028] Example 1: Combination Drugs

[0029] The combined medicine consists of 0.5 parts by weight of lactalbumin-oleic acid complex, 1 part by weight of carrageenan, 2 parts by weight of carbomer, 5 parts by weight of glycerin, 0.15 parts by weight of ethylparaben, 1 part by weight of ethyl paraben, Triethanolamine, the water composition of 90.35 parts by weight.

[0030] Preparation:

[0031] 1): Weigh each raw material according to the ratio, stir 2 parts of carbomer in 20 parts of water at 80°C until fully swollen, then add 1 part of carrageenan, stir until completely dissolved, and filter and sterilize through a 0.22 μm membrane while it is hot , to obtain No. 1 solution;

[0032] 2): Dissolve 0.15 parts of ethylparaben in 5 parts of water, filter and sterilize through a 0.22 μm membrane to obtain No. 2 solution;

[0033] 3): Add No. 2 solution to No. 1 solution under agitation and mix evenly, add 0.5 parts of triethanolamine, adjust the pH to 5.6, and obtain No. 3 sol...

Embodiment 2

[0037] Embodiment 2: combination medicine

[0038] The combined medicine consists of 0.01 weight part of lactalbumin-oleic acid complex, 0.5 weight part of carrageenan, 1 weight part of carbomer, 1 weight part of glycerin, 0.1 weight part of ethylparaben, 1 weight part The triethanolamine, the water composition of 96.39 parts by weight.

[0039] Preparation:

[0040] 1): Weigh each raw material according to the ratio, stir 1 part of carbomer in 20 parts of water at 85°C until fully swollen, then add 0.5 part of carrageenan, stir until completely dissolved, and filter and sterilize through a 0.22 μm membrane while it is hot , to obtain No. 1 solution;

[0041] 2): Dissolve 0.1 part of ethylparaben in 5 parts of water, filter and sterilize through a 0.22 μm membrane to obtain No. 2 solution;

[0042] 3): Add No. 2 solution to No. 1 solution under agitation and mix evenly, add 0.5 parts of triethanolamine, adjust the pH to 5.6, and obtain No. 3 solution;

[0043] 4): Dissolve...

Embodiment 3

[0046] Embodiment 3: combination medicine

[0047] The combination medicine consists of 1 weight part of lactalbumin-oleic acid complex, 1.5 weight parts of carrageenan, 3 weight parts of carbomer, 5 weight parts of glycerin, 0.2 weight parts of ethylparaben, 2 weight parts The triethanolamine, the water composition of 87.3 parts by weight.

[0048] Preparation:

[0049] 1): Weigh each raw material according to the ratio, stir 3 parts of carbomer in 20 parts of water at 85°C until fully swollen, then add 1.5 parts of carrageenan, stir until completely dissolved, and filter and sterilize through a 0.22 μm membrane while it is hot , to obtain No. 1 solution;

[0050] 2): Dissolve 0.2 parts of ethylparaben in 5 parts of water, filter and sterilize through a 0.22 μm membrane to obtain No. 2 solution;

[0051] 3): Add No. 2 solution to No. 1 solution under agitation and mix evenly, add 1 part of triethanolamine, adjust the pH to 5.6, and obtain No. 3 solution;

[0052] 4): Diss...

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