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Compound Ceftiofur Hydrochloride injecta

A technology for ceftiofur hydrochloride and injection, applied in the field of medicine, can solve the problems of uneven content distribution, high viscosity, poor stability, etc., and achieve the effects of treating bacterial infection, rapid absorption, and uniform content

Inactive Publication Date: 2010-07-21
商丘爱己爱牧生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide a compound ceftiofur hydrochloride injection, which can effectively solve the problems of uneven content distribution, poor stability, and local pain caused by high viscosity.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0012] The present invention is made by weight percent: ceftiofur hydrochloride 1%, sulbactam sodium 0.5%, polyethylene glycol-400 93% and dehydrated alcohol 5.5%, first polyethylene glycol-400 and cephalosporin hydrochloride Thifur was mixed, stirred, dissolved, then added absolute ethanol, stirred evenly, added sulbactam sodium, stirred, dissolved; at 35°C, filtered with a microporous membrane with a pore size of 0.2 μm, and the filtrate was divided into bottles , gland sealing, packaging, to obtain the injection solution of the present invention.

Embodiment 2

[0014] The present invention is made up of: Ceftiofur Hydrochloride 5%, Sulbactam Sodium 2.5%, Polyethylene Glycol-400 76.5% and absolute ethanol 16% by weight percent, and polyethylene glycol-400 and Cefuroxime Hydrochloride Thifur was mixed, stirred, and dissolved, then added absolute ethanol, stirred evenly, added sulbactam sodium, stirred, and dissolved; at 30°C, filtered with a microporous membrane with a pore size of 0.18, and the filtrate was divided into bottles. Gland sealing, packing, obtains the injection of the present invention.

Embodiment 3

[0016] The present invention is made by weight percentage: Ceftiofur Hydrochloride 10%, Sulbactam Sodium 5%, Polyethylene Glycol-400 65% and absolute ethanol 20%. Thifur was mixed, stirred, and dissolved, then added absolute ethanol, stirred evenly, added sulbactam sodium, stirred, and dissolved; at 32°C, filtered with a microporous membrane with a pore size of 0.16, and the filtrate was divided into bottles. Gland sealing, packing, obtains the injection of the present invention.

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Abstract

The invention relates to compound Ceftiofur Hydrochloride injecta, which effectively solves the problems of local pain and the like caused by uneven content distribution, poor stability, large viscosity. The technical scheme adopted by the invention is as follows: the injecta is prepared from the following components by weight percent: 1-15% of Ceftiofur Hydrochloride, 0.5-7.5% of Sulbactam Sodium, 48-93% of polyethylene glycol and 5-50% of absolute ethyl alcohol, wherein the total amount is 100%; firstly the polyethylene glycol and the Ceftiofur Hydrochloride are mixed, stirred and dissolved, the absolute ethyl alcohol is added and evenly stirred, and the Sulbactam Sodium is added, stirred and dissolved; and a microfiltration membrane is used to filter under the temperature of 30-45 DEG C, the filtrate is subpackged in bottles, and the bottles are gladded, sealed and packed to obtain the injecta of the invention. The invention overcomes the defects of easy delamination and inconvenient use of Ceftiofur suspension injecta in the market, and provides the injecta with stability, even content and rapid absorption; and the compound Ceftiofur Hydrochloride injecta also can effectively cure bacterial infection producing extended-spectrum beta-lactamase (ESBL).

Description

1. Technical field [0001] The invention relates to the field of medicine, in particular to a compound ceftiofur hydrochloride injection. 2. Background technology [0002] Ceftiofur, also known as Ceftiofur, is the first animal-specific cephalosporin antibiotic created by Pharmacia Upjohn in the United States. Since it was approved by the FDA in 1988 for the treatment of respiratory infections in cattle, it has been widely used in veterinary clinics at home and abroad because of its excellent antibacterial activity and dynamic process in vivo. [0003] The mechanism of action of ceftiofur is the same as that of other β-lactam drugs. It can bind to bacterial receptor binding proteins (PBPs), inhibit transpeptidase, carboxypeptidase, and endopeptidase synthesized by bacterial cell walls, and prevent peptide chain crossover. The connection is prolonged, destroying the synthesis of bacterial cell walls, and achieving rapid and efficient bactericidal effect during the breeding pe...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/43A61K9/08A61P31/04
Inventor 赵永星杜向党连明香陈五常
Owner 商丘爱己爱牧生物科技股份有限公司
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