Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology for ceftiofur hydrochloride and injection, applied in the field of medicine, can solve the problems of uneven content distribution, high viscosity, poor stability, etc., and achieve the effects of treating bacterial infection, rapid absorption, and uniform content
Inactive Publication Date: 2010-07-21
商丘爱己爱牧生物科技股份有限公司
View PDF4 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0006] In view of the above situation, in order to overcome the defects of the prior art, the object of the present invention is to provide a compound ceftio
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Examples
Experimental program
Comparison scheme
Effect test
Example Embodiment
[0011] Example 1
[0012] The present invention is made by weight percentage: ceftiofur hydrochloride 1%, sulbactam sodium 0.5%, polyethylene glycol-40093% and anhydrous ethanol 5.5%. First, polyethylene glycol-400 and cephalosporin hydrochloride Thiofu was mixed, stirred, dissolved, then added absolute ethanol, stirred evenly, added sulbactam sodium, stirred and dissolved; at 35°C, filter with a 0.2μm pore size filter membrane, and divide the filtrate into bottles , Gland, seal, and package to obtain the injection of the present invention.
Example Embodiment
[0013] Example 2
[0014] The present invention is made by weight percentage: ceftiofur hydrochloride 5%, sulbactam sodium 2.5%, polyethylene glycol -400,076.5% and absolute ethanol 16%. First, polyethylene glycol-400 and cephalosporin hydrochloride Thiofu was mixed, stirred, dissolved, then added absolute ethanol, stirred evenly, added sulbactam sodium, stirred and dissolved; at 30℃, filter with a 0.18 pore size microporous membrane, and the filtrate is divided into bottles, The injection solution of the present invention is obtained by pressing and sealing and packaging.
Example Embodiment
[0015] Example 3
[0016] The present invention is made by weight percentage: ceftiofur hydrochloride 10%, sulbactam sodium 5%, polyethylene glycol-40065% and absolute ethanol 20%. First, polyethylene glycol-400 and cephalosporin hydrochloride Thiofu was mixed, stirred, dissolved, then added absolute ethanol, stirred evenly, added sulbactam sodium, stirred, and dissolved; at 32°C, filter with a 0.16 pore filter membrane, and divide the filtrate into bottles. The injection solution of the present invention is obtained by pressing and sealing and packaging.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
Aperture
aaaaa
aaaaa
Login to view more
Abstract
The invention relates to compound Ceftiofur Hydrochloride injecta, which effectively solves the problems of local pain and the like caused by uneven content distribution, poor stability, large viscosity. The technical scheme adopted by the invention is as follows: the injecta is prepared from the following components by weight percent: 1-15% of Ceftiofur Hydrochloride, 0.5-7.5% of Sulbactam Sodium, 48-93% of polyethylene glycol and 5-50% of absolute ethyl alcohol, wherein the total amount is 100%; firstly the polyethylene glycol and the Ceftiofur Hydrochloride are mixed, stirred and dissolved, the absolute ethyl alcohol is added and evenly stirred, and the Sulbactam Sodium is added, stirred and dissolved; and a microfiltration membrane is used to filter under the temperature of 30-45 DEG C, the filtrate is subpackged in bottles, and the bottles are gladded, sealed and packed to obtain the injecta of the invention. The invention overcomes the defects of easy delamination and inconvenient use of Ceftiofur suspension injecta in the market, and provides the injecta with stability, even content and rapid absorption; and the compound Ceftiofur Hydrochloride injecta also can effectively cure bacterial infection producing extended-spectrum beta-lactamase (ESBL).
Description
1. Technical field [0001] The invention relates to the field of medicine, in particular to a compound ceftiofur hydrochloride injection. 2. Background technology [0002] Ceftiofur, also known as Ceftiofur, is the first animal-specific cephalosporin antibiotic created by Pharmacia Upjohn in the United States. Since it was approved by the FDA in 1988 for the treatment of respiratory infections in cattle, it has been widely used in veterinary clinics at home and abroad because of its excellent antibacterial activity and dynamic process in vivo. [0003] The mechanism of action of ceftiofur is the same as that of other β-lactam drugs. It can bind to bacterial receptor binding proteins (PBPs), inhibit transpeptidase, carboxypeptidase, and endopeptidase synthesized by bacterial cell walls, and prevent peptide chain crossover. The connection is prolonged, destroying the synthesis of bacterial cell walls, and achieving rapid and efficient bactericidal effect during the breeding pe...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more