Coated particles and compositions comprising same

A particle and polymer technology, applied in the directions of heterocyclic compound active ingredients, peroxy compound active ingredients, drug delivery, etc., can solve problems such as high recurrence rate and high application frequency

Inactive Publication Date: 2016-03-16
VYOME THERAPEUTICS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Limitations of current therapies include: limited exposure time, high application frequency, high relapse rate, and limited efficacy

Method used

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  • Coated particles and compositions comprising same
  • Coated particles and compositions comprising same
  • Coated particles and compositions comprising same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0277] CLAIMS 1. A particle comprising: (i) a core comprising a first active agent; and (ii) a first lipid-containing coating at least partially covering the core.

[0278] 2. A particle comprising: (i) a core comprising a first active agent; and (ii) a first carbohydrate-containing coating at least partially covering the core.

[0279] 3. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating comprising a protein at least partially covering the core.

[0280] 4. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating comprising cationic molecules at least partially covering the core.

[0281] 5. A particle comprising: (i) a core comprising a first active agent; and (ii) a first coating comprising at least two molecules selected from the group consisting of lipids, carbohydrates, proteins and cationic molecules and the coating The nucleus is at least partially covered.

[0282] 6. The particle of any of...

Embodiment 1

[0517] Example 1: Lipid-Coated Zinc Pyrithione (ZPT) Particle Dispersions (Compositions D1-D11)

[0518] Preparation: Lipids and mixtures with 1% docusate sodium (and 2% ovalbumin, if desired) in water were heated under continuous vigorous stirring to melt the lipids. Add the ZPT powder in portions to the stirring hot mixture. The resulting suspension is passed through a high pressure homogenizer at about 1200-1500 bar. The output dispersion was collected in a beaker kept in an ice bath and recirculated about 6-10 times to produce a dispersion of particles of the appropriate size (about 200 nm to about 800 nm). Size distribution was determined by ZetaSizer (ZS-90 from Malvern Instruments) and scanning electron microscope (SEM, Hitachi, S-3400N, Japan), as figure 1 and 2 shown in . The resulting dispersion was stabilized by the addition of a carbomer solution followed by neutralization with sodium hydroxide to a pH ranging from about 6.5 to about 7.0. In Table 1 some data ...

Embodiment 2

[0522] Example 2: Lipid-Coated Ketoconazole (KTZ) Particle Dispersions (Compositions D12-D16)

[0523] Preparation: A mixture of lipid and 1% aqueous solution of docusate sodium (or polyvinyl alcohol) was heated under continuous vigorous stirring to melt the lipid. Add the KTZ powder in portions to the stirring hot mixture. The resulting suspension is passed through a high pressure homogenizer at about 1200-1500 bar. The output dispersion was collected in a beaker kept in an ice bath and recirculated about 6-10 times to produce a dispersion of particles of the appropriate size (about 300 nm to about 700 nm). Determine the size distribution by ZetaSizer (ZS-90 from Malvern Instruments), as image 3 A and 3B are shown. The resulting dispersion was stabilized by the addition of a carbomer solution followed by neutralization with sodium hydroxide to a pH ranging from about 6.5 to about 7.0. In Table 2 some data for this example are given.

[0524] Table 2: Dispersion composit...

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Abstract

The invention provides species of lipid, protein, and/or cationic molecule coated active agents and compositions comprising the coated particles. The compositions can be personal care compositions such as anti-dandruff shampoo or conditioner, skin care compositions, creams, gels, toothpastes, mouth washes, and chewing gums.

Description

[0001] related application [0002] This application claims the benefit of Indian Provisional Patent Application No. 1684 / DEL / 2013, filed June 4, 2013, the contents of which are incorporated by reference under one or more of 35 U.S.C. §119(a)-119(d) Incorporated into this article as a whole. technical field [0003] The present disclosure generally relates to particles comprising an active agent and one or more lipids and / or proteins and / or carbohydrates and / or cationic molecules, compositions comprising such particles, and methods of use and manufacture thereof. Background technique [0004] Current antifungal, antibacterial, antioxidant, antiaging, antiwrinkle, wound healing and similar therapies suffer from many limitations. US Patent Publication No. 2005 / 0118276 describes lipid-coated micron-sized zinc pyrithione particles and their use in shampoos. US Patent Publication No. 2002 / 0106461 describes methods and apparatus for coating particles. WO2010 / 038066 describes ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/12A01N25/34A01N37/06A01N43/12A01N43/40A01N57/12A01N59/16A61K8/11A61K8/49A61Q5/00A61K31/44A61Q19/00A61K9/00A61K31/496
CPCA01N25/12A01N25/34A01N37/06A01N57/12A01N59/16A61K8/4933A61Q5/006A61Q19/00A61K9/0014A61K31/496A61K9/0058A61K9/006A61K9/06A61K9/5015A61K9/5036A61K9/5052A61K9/5123A61K31/085A61K31/192A61K31/327A61K31/46A61K31/4709A61K31/4745A61K31/506A61K31/55A61K31/555A61K31/60A61K8/27A61K8/29A61K8/31A61K8/347A61K8/361A61K8/368A61K8/375A61K8/466A61K8/49A61Q5/12A61Q11/00A61K8/0241A61K2800/58A61K2800/622A61K31/055A61K31/12A61K31/122A61K31/375A61K31/439A61K31/4545A01N43/40A61K2300/00A61K8/11A61K9/1676A61K9/4816A61K9/4825A61Q5/02
Inventor S·沙赖S·普拉萨德基尔提·巴贾杰
Owner VYOME THERAPEUTICS LTD
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