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Lactobacillus plantarum KLDS1001 and application of lactobacillus plantarum KLDS1001 to inhibition of streptococcus mutans

A technology of Lactobacillus plantarum and Streptococcus mutans, applied in the field of microorganisms, can solve problems such as lack of drug resistance and lack of strain safety evaluation, and achieve the effect of strong bacteriostatic ability, good adaptation to oral environment, and good bacteriostatic activity.

Active Publication Date: 2014-11-12
江苏新申奥生物科技有限公司
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Problems solved by technology

However, there is a lack of evaluation of the application safety of the strains, no research on drug resistance, and the characteristics of causing mucosal infections

Method used

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  • Lactobacillus plantarum KLDS1001 and application of lactobacillus plantarum KLDS1001 to inhibition of streptococcus mutans
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  • Lactobacillus plantarum KLDS1001 and application of lactobacillus plantarum KLDS1001 to inhibition of streptococcus mutans

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[0023] The technical solution of the present invention will be further described below in conjunction with the accompanying drawings, but it is not limited thereto. Any modification or equivalent replacement of the technical solution of the present invention without departing from the spirit and scope of the technical solution of the present invention should be covered by the present invention. within the scope of protection.

[0024] Lactobacillus plantarum KLDS1001 provided by the present invention is isolated from Xinjiang yoghurt, and its separation method is as follows: get a certain amount of yoghurt samples naturally fermented in Xinjiang, enrich in skim milk medium, and streak on the MRS plate (pH6 .5), cultured at 37°C for 24 hours, picked round, white and milky white characteristic colonies for Gram staining, and picked Gram-positive bacilli for separation and purification. The purified strains were subjected to indole test, nitrate reduction test, catalase test, and...

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Abstract

The invention discloses lactobacillus plantarum KLDS1001 and application of the lactobacillus plantarum KLDS1001 to inhibition of streptococcus mutans, belonging to the technical field of microorganisms. The lactobacillus plantarum KLDS1001 provided by the invention is collected in China general microbiological culture collection center (CGMCC) with the address of institute of microbiology of Chinese academy of sciences, 1# yard, beichen road west, chaoyang district, Beijing; the collection number is CGMCC No.9066; the collection date is April 16th, 2014. The lactobacillus plantarum KLDS1001 has an inhibition effect on the streptococcus mutans, can serve as an additive to be added to health drugs and such oral health products as chewing gum and is used for oral health; the lactobacillus plantarum KLDS1001 can serve as one of ingredients of oral cleaning products to be added into toothpaste and mouth wash for cleaning the oral cavity and reducing the number of streptococcus mutans in the oral cavity; a probiotic therapy method is developed for preventing and treating oral diseases such as decayed teeth.

Description

technical field [0001] The invention belongs to the technical field of microbes, and relates to a strain of Lactobacillus plantarum with a potential oral beneficial function and an application thereof. Background technique [0002] Lactobacillus fermentum (Lactobacillus fermentum) Y29 has a certain inhibitory effect on oral Streptococcus mutans; it has a certain tolerance to oral lysozyme and hydrogen peroxide, and can adapt to the oral environment. However, there is no relevant analysis on the acid-producing ability and cariogenic ability of the strain. The strain can produce extracellular polysaccharides and has certain tooth surface adhesion ability, so it is a potential cariogenic bacteria. [0003] Lactobacillus plantarum HO-69 has weak tooth surface adhesion ability and strong adhesion ability to oral mucosa. Non-acid antibacterial substances have antibacterial effect on Streptococcus mutans and have a broad-spectrum antibacterial effect. However, there is a lack of e...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/74A61P31/04A61P1/02C12R1/25
Inventor 孟祥晨彭悦朱文婕李艾黎
Owner 江苏新申奥生物科技有限公司
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