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Oral antibacterial composition containing nisin and polylysine and preparation method thereof

A technology of nisin and polylysine, applied in medical preparations containing active ingredients, oral care, antibacterial drugs, etc., can solve problems such as oral bacterial resistance and health threats, and achieve a bactericidal effect Good, easy to make effect

Inactive Publication Date: 2016-02-17
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the continuous improvement of people's living standards, people pay more and more attention to oral hygiene. The most common method is to use some antibacterial and anti-inflammatory toothpastes containing bactericides such as triclosan, stannous oxide, and zinc citrate. The product is easy to cause oral bacteria to develop drug resistance, and chemical preservatives are added, such as sodium benzoate, potassium sorbate, etc., which pose a certain threat to people's health

Method used

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  • Oral antibacterial composition containing nisin and polylysine and preparation method thereof
  • Oral antibacterial composition containing nisin and polylysine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add nisin 0.075% and polylysine 0.05% in the toothpaste to 57.375% deionized water and stir to dissolve, and mix with 16% sorbitol, 14% hydrated silica, 9% glycerin, 2.2% lauryl sulfate Sodium ester, 1.0% flavor, 1.0% cellulose gum, 0.23% sodium pyrophosphate, 0.22% sodium saccharin are mixed, sent to the three-in-one vacuum paste making machine, high-speed stirring and grinding for 30 minutes, vacuum degassing; adding flavor and then stirring and grinding Mix for 15 minutes to obtain a toothpaste paste, which is packaged after aseptic filling.

Embodiment 2

[0020] Add nisine 0.075% and polylysine 0.05% in the mouthwash into 99.025% deionized water and stir to dissolve it, and mix with 0.3% sodium chloride, 0.1% calcium chloride, 0.3% potassium chloride, 0.15% After the disodium hydrogen phosphate is mixed, stir at high speed until all the substances are dissolved, and package after aseptic filling.

Embodiment 3

[0022] Add 76.685% of nisin 0.075%, polylysine 0.05%, pullulan 18.0%, xanthan gum 0.04%, locust bean gum 0.06%, and carrageenan 0.19% in the refreshing tablets. ℃ deionized water; then add 0.4% glycerin, 1.5% total acesulfame potassium and essence, 3% menthol, and stir for 2~3 hours to obtain a glue solution; vacuum bubbles to obtain a film-forming solution; The film liquid is coated on the stainless steel plate with a doctor blade applicator, the thickness of the film is controlled at 20~30μm; steam drying, the drying temperature is 80~90℃, and the film is removed.

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Abstract

The invention provides an oral antibacterial composition containing nisin and polylysine. According to the composition, the growth of oral pathogenic bacteria such as porphyromonas gingivalis, actinobacillus actinomycetemcomitans, streptococcus mutans, lactic acid bacillus, staphylococcus aureus and candida albicans can be effectively inhibited, and tooth decay, gingivitis, periodontitis, ozostomia and the like can be prevented; the composition can be prepared into toothpaste, mouth wash, refreshing and tasting chips and chewing gum which are used for preventing and treating oral diseases. Meanwhile, the invention provides a preparation method of the compositions such as the toothpaste, the mouth wash, the refreshing and tasting chips and the chewing gum. The oral antibacterial composition prepared through the method can prevent and treat various oral diseases and has no toxic and side effect and allergy or stimulation phenomenon on a human body.

Description

Technical field [0001] The invention relates to an oral bacteriostatic composition containing nisin and polylysine. The composition is toothpaste, mouthwash, refreshing tablets, chewing gum, and belongs to the field of snack food processing. Background technique [0002] With the continuous improvement of people’s living standards, oral hygiene is getting more and more attention. The most common method is to use some antibacterial and anti-inflammatory toothpastes containing triclosan, stannous oxide, zinc citrate and other fungicides, but this kind of oral care The product is easy to cause oral bacteria to develop resistance, and the addition of chemical preservatives, such as sodium benzoate, potassium sorbate, etc., poses a certain threat to people's health. Therefore, people urgently need an oral care product that is safe to use and has good sterilization effects. Therefore, biological antibacterial active substances provide people with a safer and more effective choice. [0...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/88A61Q11/00A61K38/16A61K9/20A61P31/02A61P31/04A61K31/785
CPCA61K8/64A61K8/88A61K9/205A61K31/785A61K38/16A61Q11/00A61K2300/00
Inventor 孟祥璟刘少英宗工理赵文刚边玲朱希强凌沛学
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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