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Quick-release solid mouth care agent and preparation method thereof

An oral care agent and solid technology, applied in the field of daily chemicals, can solve the problems of inconvenient portability, inability to fully clean the oral cavity, poor permeability, etc., and achieve the effects of convenient consumption, fresh and pleasant smell, and strong bactericidal effect

Inactive Publication Date: 2013-02-06
广州安德生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the above-mentioned methods, toothbrushing can only remove surface dirt, chewing products cannot fully clean the oral cavity due to their low permeability, and gargling products are inconvenient to carry because of their liquid nature (for example, liquid substances above 100ml are forbidden on airplanes) , physical flushing and mechanical scrubbing are generally limited to use in hospital operations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0028] 1. Preparation of Dispersible Tablet Oral Care Products

[0029] Take one or more of solid sterilizing raw materials such as thymol, menthol, tea polyphenols, etc., mix them uniformly according to an appropriate ratio, and grind the mixture into fine powder with a particle diameter of 50 mm or less. Then the mixture fine powder and PVP-K30 are in the ratio of 20 / 1 to 50 / 1, and L-HPC is in the ratio of 1 / 1 to 50 / 1, and soluble starch is in the ratio of 1 / 1 to 5 / 1, and hard Magnesium fatty acid according to the ratio of 50 / 1 to 150 / 1, the tableting force is 0.98×10 3 ~2.94×10 3 N in the range of direct compression. The disintegration time of the obtained tablet is within 3 minutes.

[0030] If the selected bactericidal raw material is one or more of liquid essential oils (such as wintergreen oil, tea tree essential oil, etc.), or a compound of solid and liquid essential oils, the essential oils are first encapsulated with cyclodextrin to make essential oil-β- The cy...

Embodiment 1

[0032] Take 40g of thymol, 20g of menthol, and 40g of tea polyphenols (mass ratio 2 / 1 / 2) and mix them evenly, and grind the mixture into a fine powder with a particle size of 20mm. Then mix fine powder with 2.5g PVP-K30 (mass ratio 40 / 1), with 10g L-HPC (mass ratio 10 / 1), with 25g soluble starch (mass ratio 4 / 1), and 1g magnesium stearate (mass ratio Ratio 100 / 1) at a tableting force of 2.50×10 3 1000 tablets were directly prepared under N pressure. The disintegration time of the obtained tablet is about 1.4min, and other standards meet the quality requirements for dispersible tablets in the 2010 edition of the National Pharmacopoeia.

Embodiment 2

[0034] Take 12.5g of wintergreen oil, 37.5g of eucalyptus oil, 25g of mugwort oil, and 25g of clove oil (according to the mass ratio of 1 / 3 / 2 / 2) and mix them evenly to make "total essential oil". Weigh according to the mass ratio of total essential oil to β-cyclodextrin 1 / 3. First take β-cyclodextrin and appropriate amount of water and grind them thoroughly in a mortar. After mixing evenly, add the essential oil raw materials, grind for 45 minutes to form a uniform paste, spread it on a board, and dry it in an oven at 40°C for 6 hours. , to obtain essential oil-β-cyclodextrin inclusion complex. Scrape the clathrate off the board, pass through a 100-mesh sieve, and set aside.

[0035] 400g essential oil-β-cyclodextrin inclusion compound with 10g PVP-K30, with 40g L-HPC, with 100g soluble starch, with 4g magnesium stearate at a compression force of 2.50×10 3 1000 tablets were directly prepared under N pressure. The disintegration time of the obtained tablet is about 1.8min, ...

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Abstract

The invention relates to a quick-release solid mouth care agent and a preparation method thereof. The quick-release solid mouth care agent contains 5-75% of one or more than one natural product extract with anti-inflammation or bactericidal effect in percentage by weight and comprises dispersible tablets, effervescent tablets, instant tablets and xerogels. In addition, the preparation method of the quick-release solid mouth care agent disclosed by the invention is provided. The quick-release solid mouth care agent has the characteristics of wide antibacterial spectrum, efficient and rapid effect, safety and no toxicity, is capable of integrating with the advantages of mouth care products such as chewing gum, mouth wash and the like and banishing the disadvantages of the traditional mouth care products and has the advantages of good effect, convenience for carrying and simpleness in application.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and relates to an instant-release solid oral care agent and a preparation method thereof. Background technique [0002] The mouth is the beginning of the digestive tract and has many important functions. Oral care is an important part of basic care. First of all, healthy teeth can make people look good and feel better in daily life such as eating and speaking. Secondly, good oral care for critically ill patients can avoid some complications, and the condition can be observed according to the health of the oral cavity. Third, disease in the oral cavity is a harbinger of disease in other parts of the body. For example, dry oral mucosa is the first signal of water and salt metabolism disorders; patients with anemia may have persistent oral ulcers and pharyngitis; patients with leukemia may have bleeding gums. Fourth, the environment in the oral cavity is moist and rich in nutrients, which is conve...

Claims

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Application Information

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IPC IPC(8): A61K8/97A61K8/92A61Q11/00A61K8/34A61K8/35A61K8/365A61K8/49A61K8/60
Inventor 蒋庆于艳君
Owner 广州安德生物科技有限公司
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