Compound solid mouth wash effervescent tablet and preparation method thereof

A blister and solid technology, applied in the field of oral hygiene products, can solve the problems of inability to clean the oral cavity, sterilization, unsatisfactory cleaning effect of effervescent tablets, etc., and achieve the effects of improving immunity, alleviating pain, and cleaning the oral cavity.

Inactive Publication Date: 2016-10-05
成都悟道科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the cleaning effect of the existing effervescent tablets is not ideal, and cannot effectively clean the oral cavity and sterilize

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Composite solid mouthwash effervescent tablet, prepared from the following raw materials in mass percentage: honeysuckle extract 3%, chlorhexidine acetate 0.35%, glycolic acid 14%, pregelatinized starch 0.6%, sodium carboxymethyl starch 4.4% %, lactose 32.25%, acesulfame K 1.8%, polyethylene glycol 3.3%, L-cysteine ​​1.8%, sodium bicarbonate 14%, menthol 2.8%, sodium lauryl sulfate 3.2%, DL- Tartaric acid 12%, hypromellose 6.5%.

[0017] The preparation process of honeysuckle extract is as follows: add water to carry out two reflux extractions, the first reflux extraction for 110 minutes, the second reflux extraction for 50 minutes, combine the two extracts, concentrate under reduced pressure, filter, extract 3 times with n-butanol, combine For the extract, adjust the pH value of the concentrated solution to 6, recover the solvent under reduced pressure, concentrate and dry at 50°C, grind it into powder, and pass through a 160-mesh sieve.

[0018] The preparation steps...

Embodiment 2

[0024] Composite solid mouthwash effervescent tablet, prepared from the following raw materials by mass percentage: honeysuckle extract 3.5%, chlorhexidine acetate 0.3%, glycolic acid 16.0%, pregelatinized Starch 0.5%, Sodium Carboxymethyl Starch 4.7%, Lactose 30%, Acesulfame K 2.0%, Polyethylene Glycol 3.0%, L-Cysteine ​​2.0%, Sodium Bicarbonate 13%, Menthol 3.0%, Ten Sodium dialkyl sulfate 3.0%, DL-tartaric acid 13%, hypromellose 6.0%.

[0025] The preparation process of honeysuckle extract is: add water to carry out two reflux extractions, the first reflux extraction for 120 minutes, the second reflux extraction for 45 minutes, combine the two extracts, concentrate under reduced pressure, filter, extract 3 times with n-butanol, combine For the extract, adjust the pH value of the concentrated solution to 6.5, recover the solvent under reduced pressure, concentrate and dry at 53°C, grind it into powder, and pass through a 170-mesh sieve.

[0026] The preparation steps of com...

Embodiment 3

[0032] Composite solid mouthwash effervescent tablet, prepared from the following raw materials in mass percentage: honeysuckle extract 4%, chlorhexidine acetate 0.25%, ethylene glycol dew 17.75%, pregelatinized starch 0.4%, sodium carboxymethyl starch 5.0% %, lactose 27%, acesulfame K 2.2%, polyethylene glycol 2.7%, L-cysteine ​​2.2%, sodium bicarbonate 12%, menthol 3.2%, sodium lauryl sulfate 2.8%, DL- Tartaric acid 14%, hypromellose 5.5%.

[0033] The preparation process of honeysuckle extract is as follows: add water to carry out two reflux extractions, the first reflux extraction for 130 minutes, the second reflux extraction for 40 minutes, combine the two extracts, concentrate under reduced pressure, filter, extract 3 times with n-butanol, combine For the extract, adjust the pH value of the concentrated solution to 7, recover the solvent under reduced pressure, concentrate and dry at 56°C, grind it into powder, and pass through a 180-mesh sieve.

[0034] The preparation...

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PUM

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Abstract

The invention discloses a compound solid mouth wash effervescent tablet and a preparation method thereof. The effervescent tablet is prepared from honeysuckle extract, chlorhexidine acetate, mannitol, pregelatinized starch, sodium carboxymethyl starch, lactose, acesulfame, polyethylene glycol, L-cysteine, sodium bicarbonate, menthol, lauryl sodium sulfate, DL-tartaric acid and hydroxypropyl methylcellulose. The preparation method comprises the following steps: grinding and screening each raw material; uniformly mixing according to the proportion; and granulating, drying, grinding, mixing and tabletting. The effervescent tablet contains polyphenols, flavonoids, vitamins, amino acids and other multiple bio-reductive drugs, has the effects of diminishing inflammation and resisting allergy, can be used for effectively relieving development of ulcer, preventing or alleviating gingivitis to achieve the effect of strengthening teeth, can be used for killing dental bacteria, reducing injury of the dental bacteria on teeth and gum, effectively cleaning the oral cavity and reducing halitosis, and can indirectly improve the body immunity if being taken for a long time.

Description

technical field [0001] The invention relates to the field of oral hygiene products, in particular to a composite solid mouthwash effervescent tablet and a preparation method thereof. Background technique [0002] At present, mouthwash products for domestic oral hygiene are mainly mouthwash, which is in liquid form. The packaging is bulky, inconvenient to carry, cumbersome to use, takes up more space and time, and cannot control each time. Dosage. And the existing effervescent tablet that is used for oral hygiene adopts effervescent material as a kind of tablet of disintegrating agent, will produce a large amount of air bubbles when dropped into water, impels the whole tablet to disintegrate and dissolve in a short period of time, forming a clear and transparent The solution, compared with the mouthwash, has a greatly improved taste, and is small in size and more convenient to carry. However, the cleaning effect of the existing effervescent tablets is not ideal, and cannot ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/02A61K8/73A61K8/46A61K8/86A61K8/43A61K8/60A61K8/49A61K8/44A61K8/19A61K8/34A61K8/365A61Q11/00A61P1/02
CPCA61K8/97A61K8/0208A61K8/19A61K8/34A61K8/365A61K8/43A61K8/447A61K8/463A61K8/49A61K8/60A61K8/731A61K8/732A61K8/86A61Q11/00
Inventor 钟训艳
Owner 成都悟道科技有限公司
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