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Magnetic composite nano microsphere capable of emitting fluorescence and preparation thereof

A technology of magnetic composite nanometer and nanometer microspheres, which can be applied in the fields of luminescent materials, chemical instruments and methods, etc., and can solve the problems such as the decrease of fluorescence intensity and the difficulty in controlling the adsorption amount of quantum dots.

Inactive Publication Date: 2009-01-21
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The Chinese patent with publication number 1831079 utilizes aminosilane coupling agent to modify Fe 3 o 4 particles, and then through the electrostatic interaction between the amino group and the carboxyl group, the quantum dots are directly assembled on the Fe 3 o 4 The disadvantage of this method is that the amount of adsorption of quantum dots is difficult to control, and the interaction between the two particles will cause a sharp drop in fluorescence intensity due to direct contact.

Method used

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  • Magnetic composite nano microsphere capable of emitting fluorescence and preparation thereof
  • Magnetic composite nano microsphere capable of emitting fluorescence and preparation thereof
  • Magnetic composite nano microsphere capable of emitting fluorescence and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) In a 500ml three-necked bottle, add 5.0g ferric oxide powder with a particle size of 10nm, add 200ml deionized water, stir and disperse at 500rpm for 2 hours, add 2.1g citric acid dihydrate, use 1mol / 1 ammonia solution to adjust the pH value to 6.0, continue to stir for 5 hours, separate with a magnet, and wash 3-5 times with deionized water, and finally disperse ferroferric oxide in 200ml deionized water to obtain a solid content of 2.0wt%. of magnetic fluid.

[0029] (2) In a 500ml three-neck bottle, add 40ml of deionized water, 160ml of absolute ethanol in sequence, add 2g of the prepared magnetic fluid, and then add 4ml of 25wt% concentrated ammonia water and 0.2ml of ethyl orthosilicate at 500rpm After continuous stirring at 25° C. for 8 hours, the magnetic separation was followed by washing three times with deionized water and three times with absolute ethanol.

[0030] (3) In a 150ml round-bottomed beaker, disperse all the above-mentioned silica-coated magn...

Embodiment 2

[0033] (1) In a 500ml three-necked bottle, add 5.0g of ferric oxide powder washed with deionized water, add 200ml of deionized water, stir and disperse at 500rpm for 2 hours, add 2.1g of citric acid dihydrate, use 1mol / l ammonia solution to adjust the pH value to 6.0, continue to stir for 5 hours, separate with a magnet, and wash 3-5 times with deionized water, and finally disperse ferroferric oxide in 200ml deionized water to obtain a solid content of 2.0wt % ferrofluid.

[0034] (2) In a 500ml three-necked bottle, add 80ml cyclohexane, 28ml polyethylene glycol octylphenyl ether (Triton X-100), 20ml hexanol, 2g of the prepared magnetic fluid, and then add 12ml to Ionized water and 0.6ml of 25% concentrated ammonia water, stirred at 25°C and 500rpm for 20 minutes, then added 0.2ml of tetraethyl orthosilicate, continued to stir for 12 hours, then washed twice with acetone and deionized water after magnetic separation 3 times, washed 3 times with absolute ethanol.

[0035] (3...

Embodiment 3

[0038] Change the consumption of the tetraethyl orthosilicate of the step (2) of embodiment (1) into 0.8ml, all the other conditions are exactly the same, obtain particle diameter and be the CdSe / SiO of 100nm 2 / Fe 3 o 4 Fluorescent magnetic composite nanospheres. Its TEM, hysteresis loop diagram and fluorescence spectrum are as follows figure 1 , figure 2 and image 3 shown.

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Abstract

The invention discloses a magnetic composite nano microsphere capable of emitting fluorescent light and a preparation method thereof, which belong to the inorganic nanophase material field. The preparation method comprises the following steps: firstly, the sol-gel method or the reversed phase microemulsion method is adopted for performing base catalysis on alkyl silicate, and a layer of silicon dioxide is uniformly coated on the surface of inorganic magnetic nano particles; secondly, an amino silane coupling agent is adopted for performing surface finish on silicone dioxide; thirdly, semiconductor quantum dots are absorbed on the surface of the silicone dioxide through the electrostatic action between an amino group and a carboxyl group on the surface of the amino silane coupling agent; and fourthly, the magnetic composite nano microsphere with a core-shell structure capable of emitting the fluorescent light is obtained. The preparation method has easy obtained raw materials and low cost. The composite nano microsphere obtained has good stability, controllable grain size, narrow distribution, and has good magnetic responsivity and performance of being capable of emitting the fluorescent light, and the two performances are controllable. The magnetic composite nano microsphere and the preparation method can be applied in the fields of biomedicine, bioengineering, etc. including immunoassay, biological labeling and separation, cell imaging and so on.

Description

technical field [0001] The invention belongs to the field of inorganic nanometer materials, and in particular relates to a fluorescent magnetic multifunctional composite nanometer microsphere and a preparation method thereof. Background technique [0002] Quantum dots (QDs) refer to nanocrystals whose radii are smaller than or close to the exciton Bohr radius. Due to its unique quantum size effect and surface effect, quantum dots have special and excellent fluorescence emission properties in the visible light region. Alivisatos and Nie first reported that quantum dots were used as fluorescent probes instead of conventional dyes for biomarking and cell imaging in the same issue of Science in 1998, marking the beginning of research on the application of quantum dots in the field of biomedicine. Since then, quantum dots have aroused strong interest of researchers in chemistry, biology and medicine due to their excellent properties. Compared with traditional fluorescent organi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02
Inventor 王德平黄文旵刘冰周萘
Owner TONGJI UNIV
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