Extract of Maka root

A technology of extract and maca root, applied in the field of extracts of natural plants, can solve the problems that the health care effect needs to be further improved, the medicinal effect is limited, and the like

Inactive Publication Date: 2004-02-11
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also maca health products in our country, and its natural active ingredients have not been extracted,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 2.0 kilograms of maca fresh roots are collected and cleaned, and the cell crushing method is carried out in the presence of more than 90% ethanol at a concentration of 10 minutes (8-10 liters of ethanol are added to 1 kilogram of fresh roots), and then the ethanol concentration is adjusted to 70%. Keep the pH neutral for leaching (temperature<50°C) for 36 hours. The ethanol-water extract was concentrated by vacuum rotary evaporation (at a temperature of 55° C.) to obtain 190.0 g of maca ethanol-water extract, which was first passed through a reversed-phase liquid chromatography column to elute polar components such as polysaccharides in the extract with water , then collect the eluate by ethanol gradient elution, and concentrate to obtain 31.2g Maca root extract, wherein the content of glucosinolate and isothiocyanate is 36.8%, the total content of Maca amide and Macaene is 28.5% , The sterol content is 14.1%, and the extract residue is 20.6%.

Embodiment 2

[0025] Maca root extract 50.0g obtained according to the method of Example 1 was further separated and purified by high-speed countercurrent chromatography to the natural active ingredient Maca alkaloid (mainly containing Maca amide), chloroform methanol methanol NaH PO buffer solution (pH Value 4.8) Volume ratio 3□2.5□1 is the solvent system. After the mobile phase solution in the separation process was subjected to vacuum rotation at 50°C to recover the solvent, 14.2 grams of refined maca root extracts were obtained by vacuum freeze-drying, wherein the content of macamide and macaene reached 47.3%, glucosinolate and its The content of the decomposition product isothiocyanate, sterol and extract residue is 52.7%; at the same time, after the stationary phase in the separation process is fully dissolved with methanol, the solvent is recovered by vacuum rotation at 40 °C, and 21.6 grams of refined amaranth are obtained by vacuum freeze-drying. The content of glucosinolate and it...

Embodiment 3

[0027] Add 40 g of β-cyclodextrin into 1 liter of water, and heat up (55° C.) to dissolve it. Get the Maca amide that obtains in the embodiment two and Maca ene content reaches 6 grams of refined Maca root extracts of 47.3%, dissolve with 200 milliliters of 95% ethanol, then slowly add dropwise in the β-cyclodextrin solution, while Add dropwise while stirring. Continue to stir for 30 minutes after the dropwise addition, put in the refrigerator for 24 hours, then filter with suction, wash with distilled water, and dry in vacuum at -40°C to obtain a pale yellow powder clathrate. The obtained powder not only has a controlled release effect and improves the absorption efficiency of the human body, but also can cover the irritating smell of the original refined maca root extract, improve the color of the extract, and is more conducive to processing into pharmaceutical products and health care products such as tablets and capsules.

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Abstract

The present invention aims at extracting, separating and purifying the active components of Maka as one natural plant to obtain extractive with several medicinal and health care values. Fresh or dried Maka root material is extracted and separated to obtain active components and extracted residue. The active components includes glucosinolate and its decomposed product isothiocynate in 10-90 wt%,Maka amide and Maka olefin 5-70 wt% and sterol 2-30 wt%. The active components may be further prepared into capsule, tablet, and delayed releasing forms, and the prepared medicine and health food have the functions of treating climacteric syndrome, strengthening male's and female's sexuality, improving sexual function, etc.

Description

technical field [0001] The present invention relates to natural plant extracts and applications thereof. Background technique [0002] Maca (the common Chinese transliteration of MACA is also "Maca") is an annual or biennial herb of the genus Lepidium in the family Cruciferae (Cruciferae, Brassicaceae). Its scientific name is Lepidium meyenii Walp. Its other common name is It is "Peruvian Ginseng (Peruvian ginseng)". In addition to the above two English common names, Maca has more Quechua (Quechua, a large branch of South American Indians) and Spanish common names: maka, maca-maca, maino, ayak chichira, ayak willku, etc. [0003] Maca is native to the Andes mountains above 3,500 meters above sea level in Peru. It has a long history of planting and eating. Early records show that Maca appeared on the land of South America 5,800 years ago. More than 2,000 years ago, Maca was discovered by Junin Domesticated and planted by the indigenous people in the San Blas area by the lak...

Claims

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Application Information

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IPC IPC(8): A61K31/70A61P15/08A61P15/12C07B63/00C07G3/00C07G99/00C12P1/00
Inventor 余龙江金文闻程华孙友平张永忠杨英
Owner HUAZHONG UNIV OF SCI & TECH
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