Method for preparing salvianolic acid A by catalytically converting salvianolic acid B

Abstract

The invention discloses a method for preparing salvianolic acid A by catalytically converting salvianolic acid B. The method is characterized in that the converted raw material is a salvia miltiorrhiza aqueous extract (salvianolic acid B=>50%) primarily purified through combined chromatography; the concentration of the raw material salvianolic acid B is 0.5-2%; urea is taken as the catalyst; the mole ratio of urea to the salvianolic acid B is 0.3-0.7; the conversion reaction temperature is 100-125 DEG C; and the reaction time is 3-6 hours. The method has the following beneficial effects: urea is taken as the catalyst, thus greatly shortening the time for which the salvianolic acid B is in easily destroyed state and remarkably increasing the yield of the salvianolic acid A; the primarily purified salvia miltiorrhiza extract is taken as the converted raw material, thus not only removing the metal ions which are not beneficial to conversion but also removing most colloid-like impurities and frontal impurities which are not beneficial to following separation of the salvianolic acid; and the directional conversion rate of the salvianolic acid B to the salvianolic acid A prepared by the method is not less than 10% and even reaches 60%.

Description

technical field [0001] The invention relates to a method for preparing salvianolic acid A by catalytic conversion of salvianolic acid B. Background technique [0002] Salvia miltiorrhiza is the basic treatment drug for cardiovascular and cerebrovascular diseases in my country. Due to its definite curative effect, Danshen has become the traditional Chinese medicine with the largest consumption (15,000 tons / year), the highest sales, and the largest number of preparation factories in China (960 preparation factories, and the main dosage forms are: Danshen Dropping Pills, Danshen Injection, Danshen Tablets, Danshen Granules, Danshen Granules and Danshen Capsules), in addition, Danshen is also used in the treatment of pulmonary heart disease, hyperlipidemia, hyperviscosity syndrome, asthma, Bronchopneumonia, hepatitis, liver cirrhosis, nephrotic syndrome, arthritis, diabetic circulatory disorders, various bacterial and viral infections, anti-endotoxin, tumor, scleroderma, dermatiti...

AI Technical Summary

Problems solved by technology

[0007] 1. Metal ions (such as iron, copper, aluminum, calcium, etc.) in the water extract will aggravate the destruction of salvianolic acid B and Dan A during the conversion process, seriously affecting the yield of Dan A;

[0008] 2. The affinity between salvianolic acid A and pseudo-colloidal impurities is greater than that of salvianolic acid B, which will increase the difficulty of subsequent separation;

[0010] 4. If the conversion volume is too large, it will increase equipment investment, reagent and artificial energy consumption

[0013] In summary, although the technology of heat treatment of salvia miltiorrhiza extract to prepare salvianolic acid A has basically solved the problem of the source of salvianolic acid A, it still has the problems of low conversion rate, unfavorable separation and purification and low yield of separation and purification.