The invention provides a skin care isolation cream containing minerals and plant extracts, including: minerals, plant source extracts, biological extracts and auxiliary agents, the minerals are titanium dioxide, kaolin, mica, magnesium sulfate, chloride Sodium and zinc oxide, the plant source extracts are Centella asiatica extract, Polygonum cuspidatum root extract, Scutellaria baicalensis root extract, tea leaf extract, Glycyrrhiza glabra root extract, Chamomile flower extract, Rosemary leaf extract , purslane extract and grape fruit extract, the biological extracts are β-glucan, bio-glucose-1, allantoin, Saccharomyces cerevisiae extract, palmitoyl tripeptide-1 and hyaluronic acid sodium. The active ingredient of the skin care isolation cream prepared by the invention has a small particle size, is skin-friendly and closely adhered, is easy to absorb, is green and environmentally friendly, has the advantages of beautifying skin, sun protection and skin care, and has no toxicity and no side effects on the skin.