Functions and application of SHPS1 in treatment of post-vascular injury restenosis

Abstract

The invention discloses functions and application of SHPS1 in treatment of post-vascular injury restenosis, belonging to the field of functions and applications of genes. SHPS1 gene knockout mice and wild type mice are taken as experimental subjects, and due to a vascular injury model, the mouse neointima formation, vascular wall cell proliferation level and smooth muscle cell phenotype transform are detected. The result proves that SHPS1 gene knockout can obviously promote neointima neogenesis and cell proliferation and promote transformation of smooth muscle cells from a shrinkage manner to a synthetic manner. Thus the functions of SHPS1 in post-vascular injury restenosis are realized, which mainly shows that SHPS1 has the functions of inhibiting neointima formation and cell proliferation and inhibiting smooth muscle cell phenotype transformation. Aiming at the functions of the SHPS1, the SHPS1 can be used for preparing medicines and arterial stents for preventing, relieving and / or treating the post-vascular injury restenosis.

Description

technical field

[0001] The invention belongs to the field of gene function and application, and specifically relates to the function and application of SHPS1 in the treatment of restenosis after vascular injury, specifically the application of SHPS1 in the preparation of drugs for preventing, alleviating and / or treating restenosis after vascular injury. Background technique

[0002] With the change of dietary structure and the aging process of the population, atherosclerotic occlusive lesions are increasing year by year and have become one of the main causes of death in our country. At present, there is no cure for this kind of disease. The treatment methods of vascular surgery include balloon dilation, stent placement and arterial bypass, but restenosis after vascular reconstruction seriously affects the treatment effect. Studies have shown that in the process of injury formation, the excessive proliferation of neointima and media tissue and the accompanying extracellular m...

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