22 results about "Insertion reaction" patented technology

A method of producing a fluorine-containing compound is a method of producing a compound (30) having partial structure (3) by an insertion reaction of compound (20) into compound (10) that has partial structure (1), in the presence of an ionic catalyst formed from a specific monovalent anion and a counter cation. In the formulas, * represents a bonding site, and X1 and R1 to R4 each independently represents a hydrogen atom, a fluorine atom, a chlorine atom, or an organic group having a carbon number of 1 to 20 which may have a substituent.

The invention relates to a method for preparing a cycloheptatrienone derivative, and belongs to the technical field of bioengineering. The invention provides a method for preparing a cycloheptatrienone derivative, which is based on a framework editing strategy of biological catalysis and comprises the following steps of: performing biological catalysis on a substrate and an auxiliary substrate by using a phenol derivative as a substrate and nitroalkane as an auxiliary substrate and using multi-copper oxidase and / or a microorganism for producing the multi-copper oxidase as a catalyst to obtain the cycloheptatrienone derivative. The auxiliary substrate is used as a C1 unit to be inserted into the skeleton of the aromatic ring substrate for editing, so that the cycloheptatrienone derivative is generated. According to the method, multi-copper oxidase is used as a catalyst, nitroalkane which is simple, easy to obtain, safe and highly stable is used as a C1 unit, and a phenol derivative is successfully converted into the cycloheptatrienone derivative. According to the method, a single carbon insertion mediated skeleton editing biological catalysis strategy is constructed, the strategy breaks through the limitation of a traditional carbene insertion reaction, and the method has a great application prospect in skeleton modification in the field of chemical and biological catalysis.

The utility model discloses a sampling device for a heterogeneous reaction kettle. The sampling device comprises a sampling sleeve and a sampling lifter which are fixed on the inner wall of the reaction kettle, the lower end of the sampling sleeve is inserted into reaction liquid in the reaction kettle, the upper end of the sampling sleeve is fixed on the reaction kettle through a flange, and the sampling sleeve is positioned between the stirring paddle and the inner wall of the reaction kettle; the flange is connected with a T-shaped three-way pipe, a main pipe of the T-shaped three-way pipe and the sampling sleeve are coaxially arranged, one side, far away from the sampling sleeve, of the main pipe of the T-shaped three-way pipe is connected with a first valve, and one side, far away from the T-shaped three-way pipe, of the first valve is connected with a funnel; a branch pipe of the T-shaped three-way pipe is connected with a second valve, and the second valve is used for being connected with an external nitrogen source; the sampling lifter sequentially penetrates through the funnel, the opened first valve, the main pipe of the T-shaped three-way pipe, the flange and the sampling sleeve through the rope for sampling. According to the utility model, the sampling lifter and the rope are isolated from the stirring paddle through the sampling sleeve, so that the rope is prevented from being wound on the stirring paddle, and the stirring paddle does not need to be stopped during sampling. In addition, the sampling lifter is used for sampling from the sampling sleeve, so that the problem of blockage of the sampling sleeve can be effectively avoided.

The invention discloses a method for directly synthesizing ethanol by coupling a continuous CH4-CO2 non-isothermal process with a modified ZSM-5 molecular sieve, belongs to the technical field of chemical engineering, and solves the technical problems that a catalyst is easy to inactivate during high-temperature conversion in a CH4 and CO2 co-conversion reaction process, the reaction is limited by dynamics and thermodynamics under a low-temperature condition and the like. According to the solution, two gases, namely methane and carbon dioxide, are continuously fed into a non-isothermal continuous moving bed reactor, so that methane activation dehydrogenation and carbon dioxide insertion reaction are carried out at two different temperatures, and the two raw gases are not backmixed; a ZSM-5 modified catalyst is added into a continuous moving bed reactor and is used for catalyzing CH4 and CO2 to be coupled to directly synthesize ethanol. According to the method, high-yield and high-selectivity direct synthesis of ethanol from CH4 and CO2 under mild conditions is realized, the process is simple, the process is green, and the method has remarkable technical advantages and good industrial application prospects.

The application discloses a dicarboxylic acid-quaternary ammonium salt synergistic catalytic system and application thereof in carbon dioxide and epoxide reaction. The catalytic system comprises a dicarboxylic acid compound and a quaternary ammonium salt, wherein the dicarboxylic acid serves as a hydrogen bond donor, the quaternary ammonium salt provides a nucleophilic anion, and both of them synergistically promote epoxide activation and carbon dioxide insertion reaction. The dicarboxylic acid preferably has a first dissociation constant pKa1 of 4.0-7.0, and the quaternary ammonium salt is preferably a bromide or iodide tetraalkylammonium salt. In the presence of the catalytic system, carbon dioxide can be efficiently reacted with various epoxides under relatively mild conditions to generate corresponding cyclic carbonates. The catalytic system has the advantages of simple structure, no metal, high catalytic efficiency, wide substrate application range and the like, and has a good industrial application prospect.

The invention provides a trihydrogermane, a dihydrogermane, a monohydrogermane, and a method for preparing the trihydrogermane, the dihydrogermane and the monohydrogermane. Germanium dichloride is used as an initial raw material, and is subjected to an insertion reaction with a carbon halogen bond of halogenated hydrocarbon, and then reduction treatment is performed, so that the trihydro germane compound is efficiently constructed. Further, coupling of an olefin precursor and a germanium source is realized based on a metal-free condition or a zirconium-catalyzed olefin hydrogen germanization reaction, so that dihydrogermane and monohydrogen germane compounds are synthesized. The germane compound obtained by the invention can be separated and purified by conventional means such as extraction, column chromatography and the like, is stable to air and humidity, and shows a good industrial application prospect.

The invention discloses a high-throughput screening synthesis method of an oxoisoindoline-carboxylic acid compound, which comprises the following steps: in a polar solvent, carrying out carbonyl insertion reaction on a compound as shown in a formula I in the presence of a Pd catalyst and alkali under a heating condition to obtain an oxoisoindoline-carboxylic acid compound as shown in a formula II, in the formula, X is CH2 or C = O, and Y is CH3 or H. The oxo-isoindoline-carboxylic acid compound is synthesized and constructed through high-throughput screening, a series of oxo-isoindoline-carboxylic acid compounds are obtained, and optimal reaction conditions are obtained in an extremely short time through proper high-throughput screening, so that the reaction conditions of high yield and high compatibility are quickly locked, and the yield of the oxo-isoindoline-carboxylic acid compound is greatly improved. The innovative breakthrough of the method in the aspect of reaction mechanism is more highlighted, and a solution capable of being popularized is provided for efficient synthesis of similar carboxylic acid derivatives.

The invention discloses a light response type self-adaptive interface bridging agent, a preparation method thereof and application of the light response type self-adaptive interface bridging agent in mixed plastic recovery, and belongs to the technical field of high polymer material recovery. The interface bridging agent is symmetrical in molecular structure, the two ends of the interface bridging agent are 3-(trifluoromethyl)-3H-diaziridine bridging end groups capable of generating carbene, and the middle part of the interface bridging agent comprises an azobenzene photosensitive driving unit and a self-adaptive connecting unit (such as a disulfide bond). The core of the method is that illumination with different wavelengths is utilized: under ultraviolet irradiation, azobenzene is isomerized into cis-conformation, internal stress is generated to promote bond breakage of a connecting unit, and self-adaptive network dissociation is realized; under the irradiation of visible light, the azobenzene recovers trans-conformation, and the connection unit bonds are recombined to realize network reconstruction. When the mixed plastic is recycled, the interface bridging agent can reinforce interface bonding through a carbene insertion reaction to form a'molecular rivet ', and dissociation and reshaping of the material are realized through light-operated reversible regulation and control. According to the invention, remote, reversible and accurate regulation and control of the material performance are realized, the process is mild, the recovery efficiency of the incompatible mixed plastic and the performance of the regenerated product are obviously improved, and the method has a good application prospect.

The invention belongs to the technical field of optical functional materials, and particularly relates to a polymer cross-linking agent, a preparation method thereof and application of the polymer cross-linking agent in organic electro-optical materials. The invention provides a polymer cross-linking agent which has a structure as shown in a formula I. A cross-linking group is introduced to a polymer cross-linking agent, the group can release nitrogen to generate reactive carbene under the condition of illumination (350-450 nm ultraviolet irradiation) or heating, the carbene is subjected to a cross-linking reaction with a polymer framework and a chromophore through a C-H bond insertion reaction, and a stable three-dimensional network structure is formed; the method is suitable for improving the glass transition temperature and thermal stability of various structural materials, and has universality and wide applicability. The technology provides a new way for developing flexible optoelectronic devices, and the low-energy-consumption and high-precision crosslinking characteristics of the flexible optoelectronic devices show wide prospects in the fields of wearable devices and integrated photonic chips.

The utility model discloses a kind of reaction systems for organic peroxidation, belong to chemical experiment equipment technical field.It includes reaction unit and stirring unit, reaction unit includes reaction cavity, it is used to accommodate reactant in it, stirring unit inserts reaction cavity, the reactant in reaction cavity is stirred, further include foam collecting unit, the foam collecting unit includes foam collection chamber, foam drainage pipe and foam trapping tank, the foam collection chamber is fixed in reaction cavity inner wall, foam drainage pipe one end communicates foam collection chamber inside, foam drainage pipe other end connects foam trapping tank, wherein, the nozzle of foam drainage pipe is towards the notch of foam trapping tank, reaction end line is set on foam collection chamber.The utility model aims at accurate judgment reaction end.

The invention relates to the technical field of chemical pharmacy, and discloses a method for preparing a topramezone intermediate 3-(4, 5-dihydro-3-isoxazolyl)-2-methyl-4-(methylsulfonyl) benzoic acid, which comprises the following steps: S1, taking 3-(3-halo-2-methyl-6-(methylsulfonyl) phenyl)-4, 5-dihydroisoxazole as an initial raw material, and reacting at the temperature of 50-60 DEG C for 1-2 hours to obtain a topramezone intermediate 3-(4, 5-dihydro-3-isoxazolyl)-2-methyl-4-(methylsulfonyl) benzoic acid; under the catalysis of a metal catalyst, carrying out carbonyl insertion reaction on the intermediate carboxylic acid ester and formate to prepare an intermediate carboxylic acid ester; s2, the carboxylic ester is subjected to a hydrolysis reaction, and a target compound I, namely, 3-(4, 5-dihydro-3-isoxazolyl)-2-methyl-4-(methylsulfonyl) benzoic acid, is prepared. A target product is synthesized through a carbonyl insertion reaction and a two-step reaction, and the reaction steps are short. Compared with carbon monoxide, carbon monoxide is replaced by formate, so that the loss of carbon monoxide is reduced, the raw materials are easily available, the transportation and supply are convenient, and the reaction yield is better.

The invention belongs to the technical field of catalyst preparation and organic synthesis, and particularly discloses a cobalt-nickel bimetallic catalyst and a preparation method and application thereof.According to the cobalt-nickel bimetallic catalyst, silicon dioxide serves as a carrier, and cobalt and nickel bimetallic active components with the molar ratio being 1: 2-2: 1 are evenly loaded; the catalyst is prepared through silica template pretreatment, mixing of a cobalt source and a nickel source and reduction of a reducing agent, and is simple to synthesize, low in cost and recyclable. The catalyst is applied to preparation of dimethyl 2, 6-naphthalate, 6-hydroxy-2-naphthoic acid which is easy to obtain and low in cost can be used as a starting raw material, a target product can be obtained through esterification, hydroxyl protection and carbonyl insertion, the conversion rate of the carbonyl insertion reaction can reach 90.1%, aftertreatment and purification are simple, the product purity is larger than or equal to 99.90%, and the catalyst is suitable for industrial production. And the cobalt-nickel bimetallic catalyst can be recycled, so that the production cost is remarkably reduced, the production period is remarkably shortened, the industrial application prospect is very strong, and a foundation is laid for industrialization of the PEN material.

This invention provides a method for the rearrangement nitrogen insertion reaction of indole phosphonium salts and tert-butyl (p-toluenesulfonyloxy) carbamate under potassium carbonate-promoted conditions, synthesizing a series of 3-aminoindole compounds. The technical solution of this invention has the following significant advantages: it eliminates the need for expensive metal catalysts, significantly reducing production costs; the reaction conditions are mild and simple, and the reaction can be carried out efficiently at room temperature with only the addition of a base and an amine source, achieving excellent chemoselectivity, regioselectivity, broad functional group compatibility, and excellent atom economy.

The invention provides a binuclear iron catalyst as well as a preparation method and application thereof, and belongs to the technical field of organic synthesis. And complexing the Salen ligand and anhydrous ferric trichloride to form the binuclear iron complex Fe-1 supported by the Salen ligand. In a chloralkane solvent, a binuclear iron complex Fe-1 is used as a catalyst, and a chiral ligand, triethyl substituted silane and alpha-phenyl-alpha-diazobenzyl acetate are added to react in an oil bath, so that the chiral organosilicon compound can be obtained at the yield of 72% and the enantioselectivity that ee is equal to 97%. The binuclear iron catalyst Fe-1 has good catalytic performance on enantioselective carbene insertion reaction of Si-H bonds, the steps are simple and convenient, the reaction conditions are mild, the product is low in price and easy to obtain, the product yield is high, the stereoselectivity is high, the environmental and biological compatibility is good, and the binuclear iron catalyst Fe-1 is green and environmentally friendly and has good popularization value.

The invention discloses a method for preparing chiral lactam from prochiral ketone, and belongs to the technical field of chemical synthesis. According to the method, chlorobenzene or toluene or a chlorobenzene / diethyl ether mixed solution is used as a solvent, under the action of a chiral catalyst, prochiral cyclic ketone and sulfonyl hydroxylamine are subjected to a desymmetrical nitrogen atom insertion reaction at-78 DEG C to 25 DEG C, high-stereoselectivity chiral lactam is prepared in one step, and the reaction time is 2-8 h. The method has the advantages that the raw materials are low in price and easy to obtain, the chiral catalyst is commercially available and small in dosage, the product has excellent stereoselectivity, post-treatment is simple and convenient, and a novel green and economical way with wide industrial application prospects is provided for synthesis of chiral drugs and fine chemicals.

A system for monitoring the alkalinity of a treatment liquid in a treatment tank includes a reaction tank; an indicator burette which drops an indicator into the reaction tank; a reagent burette which drops an acidic reagent into the reaction tank; a probe-type absorptiometer to be inserted into the reaction tank; a measuring device which analyzes the transmittance of a solution detected by the absorptiometer to calculate the alkalinity; a first system that collects the treatment liquid from the treatment tank for storing and supplies the treatment liquid to the reaction tank; a control device which controls the operation of the first system so as to supply the treatment liquid to the reaction tank, outputs a completion signal to the measuring device, and controls a discharge system so as to discharge the treatment liquid in the reaction tank, when the calculation of alkalinity by the measuring device is completed.

The application discloses a method for synthesizing tetraaryl manganese porphyrin by simultaneously condensing aldehyde and pyrrole and oxidizing and inserting manganese salt, which comprises the following steps: adding anhydrous aluminum chloride, aromatic aldehyde, pyrrole and manganese dichloride into DMF in sequence under stirring, heating and refluxing the reaction for a certain time, stopping the reaction, cooling, and placing overnight near 273K, and then filtering to obtain manganese porphyrin purple-black crystals. The method directly uses aromatic aldehyde, pyrrole and manganese dichloride as raw materials, does not need to use porphine, and does not use strong corrosive organic acid as a solvent. High-purity tetraaryl manganese porphyrin is obtained in high yield without using complex separation means, and industrial production is easy to realize.

The application discloses a kind of metal imidazole salt bifunctional polyionic liquid catalyst and its preparation method and application, belong to polyionic liquid synthesis and CO2 capture and catalytic conversion technical field.The preparation method of the catalyst is first obtained by metal insertion reaction 1-vinylimidazole salt ionic liquid monomer, then with benzoyl peroxide as initiator, radical polymerization reaction occurs with crosslinking agent, and metal coordination containing bifunctional polyionic liquid catalyst is obtained.The catalyst provided in the application, metal cation as Lewis acidic site, halogen anion as nucleophile, both synergistically can efficiently catalyze the cycloaddition reaction of carbon dioxide and epoxide compound, as heterogeneous catalyst, recovery is simple, and recycling stability is good, easy to be popularized and applied in industry.

The invention discloses a metal imidazolium salt bifunctional polyion liquid catalyst as well as a preparation method and application thereof, and belongs to the technical field of polyion liquid synthesis and CO2 capture and catalytic conversion. The preparation method of the catalyst comprises the following steps: firstly, obtaining a 1-vinyl imidazole salt ionic liquid monomer through metal insertion reaction, and then carrying out free radical polymerization reaction on benzoyl peroxide serving as an initiator and a cross-linking agent to obtain the difunctional polyionic liquid catalyst containing metal coordination. According to the catalyst, metal cations serve as Lewis acid sites, halogen anions serve as nucleophilic reagents, the metal cations and the halogen anions cooperate to efficiently catalyze cycloaddition reaction of carbon dioxide and epoxy compounds, and the catalyst serves as a heterogeneous catalyst, is easy to recycle, good in recycling stability and easy to industrially popularize and apply.

The invention relates to a degradable copolyester, a monomer used by the degradable copolyester and a preparation method of the monomer, and the preparation method of the monomer comprises the following steps: adding protonic acid, halide and a compound as shown in a formula (1) into an organic solvent, carrying out heating reaction under a protective atmosphere, and after the reaction is finished, separating to obtain an intermediate product as shown in a formula (2); and adding the intermediate product, an alkaline compound, a transition metal catalyst and a phosphine ligand into a solvent, introducing CO, carrying out a heating reaction, and after the reaction is finished, carrying out separation to obtain the monomer as shown in a formula (3). According to the method, the monomer based on the terephthalic acid and propyl alcohol ester and shown in the formula (3) can be obtained through the halogenation reaction and the carbonyl insertion reaction, the raw materials used in the reaction are low in cost and safe, the reaction conversion rate, selectivity and stability are high, and the product is easy to purify and separate.

The application belongs to the technical field of optical functional materials, and particularly relates to a polymer crosslinking agent, a preparation method thereof and application thereof in organic electro-optical materials. The application provides a polymer crosslinking agent with a structure shown in formula I. The application introduces a crosslinking group on the polymer crosslinking agent. The group can release nitrogen to generate a reactive carbene under light (350-450 nm ultraviolet light irradiation) or heating. The carbene is inserted into a C-H bond to react with a polymer framework and a chromophore to form a stable three-dimensional network structure. The application is suitable for improving the glass transition temperature and thermal stability of various structural materials, and has universality and wide applicability. The technology provides a new way for developing flexible optoelectronic devices, and the low-energy-consumption and high-precision crosslinking characteristics have broad prospects in the fields of wearable devices and integrated photon chips.

The invention provides a 9-bit-azabicyclo [3, 1, 0] hexyl methyl substituted o-carborane compound and a preparation method thereof, and the 9-bit-azabicyclo [3, 1, 0] hexyl methyl substituted o-carborane compound is synthesized by one-step reaction of a 1, 6-enyne compound, an o-carborane compound and a reaction solvent under the action of a carbene gold catalyst. According to the invention, a 1, 6-enyne compound which is cheap and easy to obtain is used as a non-diazo carbene precursor, an o-carborane compound is used as a raw material, and under the action of a carbene gold catalyst, the 9-position-azabicyclo [3, 1, 0] hexyl methyl substituted o-carborane compound is highly selectively and rapidly obtained through a carbene regioselective boron-hydrogen bond insertion reaction route.