49 results about "Insertion reaction" patented technology

The invention relates to a method for constructing a C-N bond or a C-C bond through an insertion reaction of oxygen-sulfur ylide and aromatic amine. According to the method, tris (pentafluorophenyl) borane is taken as a catalyst, oxygen-sulfur ylide and aromatic amine are taken as raw materials, and N-H or C-H insertion reaction is carried out under different temperatures and solvents. According to the method, the defect that a metal catalyst or an oxidizing agent is used traditionally is overcome, and on the basis of the method, various alpha-amino-acid ester derivatives or diaryl acetate derivatives can be obtained by using different aromatic amines and oxygen-sulfur ylide as substrates. According to the method, the raw materials are easy to obtain, the operation is simple, the use of a catalyst and an oxidizing agent is avoided, and the method is a mild, effective, feasible and environment-friendly method for preparing the alpha-amino-acid ester and the diaryl acetate and has important application value.

The utility model relates to the technical field of chemical reaction kettles, in particular to a chemical safety reaction kettle convenient for sampling. Comprising a reaction kettle body and a sampling pipe, a sampling opening, a cleaning sleeve and bristles are formed in the upper portion of the reaction kettle body, the sampling pipe is inserted into the cleaning sleeve, a vacuum pump is installed on the top of the sampling pipe, a one-way valve is installed on the vacuum pump, and a communicating air channel is formed in the sampling pipe; a telescopic motor, a lifting pull rod and a spring are mounted at the top of the sampling tube, a piston plug is inserted into the lower half part of the lifting pull rod, and a sealing gasket is adhered to the outer side of the piston plug. The sampling pipe is inserted into the reaction kettle body from the upper portion of the sampling opening, the top of the sampling pipe shields the top of the sampling opening, external gas is prevented from entering the reaction kettle, bristles in the sampling opening are matched with the cleaning sleeve, the sampling pipe can be guided and limited when the sampling pipe enters the reaction kettle body, and the sampling pipe is prevented from being blocked. The sampling pipe can stably and quickly enter the reaction kettle body.

The utility model belongs to the technical field of nucleic acid amplification detection, and particularly relates to a nucleic acid amplification detection device, which comprises a shell, a reaction bin, a detection device and a control device, wherein the upper end surface of the shell is provided with a test tube insertion reaction bin; the at least one detection mechanism comprises a multi-channel transmitting assembly and a multi-channel receiving assembly which are arranged on the outer side of the test tube detection position in the reaction bin; wherein the multi-channel emission assembly emits at least one beam of excitation light into the test tube to enable a reagent in the test tube to generate fluorescence, and the multi-channel receiving assembly receives the corresponding fluorescence and detects the intensity corresponding to each fluorescence; by arranging the detection mechanism, the functional requirement of double-channel fluorescence multi-joint detection is met on the basis of single-channel fluorescence detection, the application range is wide, the detection device can be used for multi-joint detection, and the requirements can be met by one-time detection experiment aiming at different targets.

A method of producing a fluorine-containing compound is a method of producing a compound (30) having partial structure (3) by an insertion reaction of compound (20) into compound (10) that has partial structure (1), in the presence of an ionic catalyst formed from a specific monovalent anion and a counter cation. In the formulas, * represents a bonding site, and X1 and R1 to R4 each independently represents a hydrogen atom, a fluorine atom, a chlorine atom, or an organic group having a carbon number of 1 to 20 which may have a substituent.

The invention relates to a method for preparing a cycloheptatrienone derivative, and belongs to the technical field of bioengineering. The invention provides a method for preparing a cycloheptatrienone derivative, which is based on a framework editing strategy of biological catalysis and comprises the following steps of: performing biological catalysis on a substrate and an auxiliary substrate by using a phenol derivative as a substrate and nitroalkane as an auxiliary substrate and using multi-copper oxidase and / or a microorganism for producing the multi-copper oxidase as a catalyst to obtain the cycloheptatrienone derivative. The auxiliary substrate is used as a C1 unit to be inserted into the skeleton of the aromatic ring substrate for editing, so that the cycloheptatrienone derivative is generated. According to the method, multi-copper oxidase is used as a catalyst, nitroalkane which is simple, easy to obtain, safe and highly stable is used as a C1 unit, and a phenol derivative is successfully converted into the cycloheptatrienone derivative. According to the method, a single carbon insertion mediated skeleton editing biological catalysis strategy is constructed, the strategy breaks through the limitation of a traditional carbene insertion reaction, and the method has a great application prospect in skeleton modification in the field of chemical and biological catalysis.

The utility model discloses a sampling device for a heterogeneous reaction kettle. The sampling device comprises a sampling sleeve and a sampling lifter which are fixed on the inner wall of the reaction kettle, the lower end of the sampling sleeve is inserted into reaction liquid in the reaction kettle, the upper end of the sampling sleeve is fixed on the reaction kettle through a flange, and the sampling sleeve is positioned between the stirring paddle and the inner wall of the reaction kettle; the flange is connected with a T-shaped three-way pipe, a main pipe of the T-shaped three-way pipe and the sampling sleeve are coaxially arranged, one side, far away from the sampling sleeve, of the main pipe of the T-shaped three-way pipe is connected with a first valve, and one side, far away from the T-shaped three-way pipe, of the first valve is connected with a funnel; a branch pipe of the T-shaped three-way pipe is connected with a second valve, and the second valve is used for being connected with an external nitrogen source; the sampling lifter sequentially penetrates through the funnel, the opened first valve, the main pipe of the T-shaped three-way pipe, the flange and the sampling sleeve through the rope for sampling. According to the utility model, the sampling lifter and the rope are isolated from the stirring paddle through the sampling sleeve, so that the rope is prevented from being wound on the stirring paddle, and the stirring paddle does not need to be stopped during sampling. In addition, the sampling lifter is used for sampling from the sampling sleeve, so that the problem of blockage of the sampling sleeve can be effectively avoided.

The invention discloses a quantum dot direct photoetching processing method and application thereof. The processing method comprises the following steps: providing a quantum dot mother solution, and coating and volatilizing a solvent to form a photoetching quantum dot wet film; carrying out patterning illumination to obtain a photoetching film; cleaning and developing by using a developing solution to obtain a patterned quantum dot layer; wherein the quantum dot mother liquor contains quantum dots and a cross-linking agent, and the molecular structure of the cross-linking agent contains a plurality of acetophenone derivative photosensitive groups. According to the invention, a novel cross-linking agent is adopted, the quantum dots are cross-linked and the solubility is changed by utilizing an insertion reaction with surface ligands of the quantum dots, and direct patterning photoetching is realized by matching with a dissolution effect of a developing solution on non-cross-linked parts, so that a better resolution ratio can be obtained, and meanwhile, the negative influence on the characteristics of the quantum dots is extremely small; even some characteristics can generate positive influence, the optical performance of the quantum dots is well maintained or improved, and the electroluminescent performance of the quantum dot device is also remarkably improved.

The invention discloses a preparation method of a visible light induced stripping pressure-sensitive adhesive, which comprises the following steps: firstly, carrying out free radical solution polymerization on a (methyl) acrylate monomer containing a p-methylbenzenesulfonylhydrazone (C = NNHTs) structure and a second monomer under the action of an ultraviolet light initiator to obtain an initial polymer solution; and then adding an organic alkali additive into the system, uniformly mixing, coating on the surface of a base material, and volatilizing the solvent to obtain the pressure-sensitive adhesive. The pressure-sensitive adhesive is suitable for surface bonding of various materials such as metal, plastic and glass, due to the addition of the organic alkali, a 4-methylbenzenesulfinic acid (HTs) structure can be removed from C = NNHTs in a polymer to generate a diazo compound (C = N2), the diazo compound can be activated under visible light to generate a free-state carbene intermediate, then a C-H bond insertion reaction is carried out in situ, and the pressure-sensitive adhesive is prepared. The crosslinking density and cohesive energy strength of the pressure-sensitive adhesive are improved, the pressure-sensitive adhesive is induced to be stripped on the surface of a base material according to needs, and the adhered base material is not damaged in the process.

The invention relates to the field of synthesis of pesticide intermediates, in particular to a preparation method of a pyraflufen-ethyl key intermediate, which is characterized in that a compound 1 shown in the following figure and CO are subjected to carbonyl insertion reaction in ethanol under the catalysis of a cobalt catalyst to generate a compound 2, and the latter is the key intermediate of the pesticide pyraflufen-ethyl. According to the method, the conversion of alpha-chloroketone to beta-keto ester is realized in one step, the route is simplified, the use of expensive reagents is avoided, the cost is reduced, three wastes, reaction and post-treatment are simple, the defects in the prior art are overcome, and the method has industrial value. # imgabs0 #

The invention discloses a method for directly synthesizing ethanol by coupling a continuous CH4-CO2 non-isothermal process with a modified ZSM-5 molecular sieve, belongs to the technical field of chemical engineering, and solves the technical problems that a catalyst is easy to inactivate during high-temperature conversion in a CH4 and CO2 co-conversion reaction process, the reaction is limited by dynamics and thermodynamics under a low-temperature condition and the like. According to the solution, two gases, namely methane and carbon dioxide, are continuously fed into a non-isothermal continuous moving bed reactor, so that methane activation dehydrogenation and carbon dioxide insertion reaction are carried out at two different temperatures, and the two raw gases are not backmixed; a ZSM-5 modified catalyst is added into a continuous moving bed reactor and is used for catalyzing CH4 and CO2 to be coupled to directly synthesize ethanol. According to the method, high-yield and high-selectivity direct synthesis of ethanol from CH4 and CO2 under mild conditions is realized, the process is simple, the process is green, and the method has remarkable technical advantages and good industrial application prospects.

The application discloses a dicarboxylic acid-quaternary ammonium salt synergistic catalytic system and application thereof in carbon dioxide and epoxide reaction. The catalytic system comprises a dicarboxylic acid compound and a quaternary ammonium salt, wherein the dicarboxylic acid serves as a hydrogen bond donor, the quaternary ammonium salt provides a nucleophilic anion, and both of them synergistically promote epoxide activation and carbon dioxide insertion reaction. The dicarboxylic acid preferably has a first dissociation constant pKa1 of 4.0-7.0, and the quaternary ammonium salt is preferably a bromide or iodide tetraalkylammonium salt. In the presence of the catalytic system, carbon dioxide can be efficiently reacted with various epoxides under relatively mild conditions to generate corresponding cyclic carbonates. The catalytic system has the advantages of simple structure, no metal, high catalytic efficiency, wide substrate application range and the like, and has a good industrial application prospect.

The invention provides a trihydrogermane, a dihydrogermane, a monohydrogermane, and a method for preparing the trihydrogermane, the dihydrogermane and the monohydrogermane. Germanium dichloride is used as an initial raw material, and is subjected to an insertion reaction with a carbon halogen bond of halogenated hydrocarbon, and then reduction treatment is performed, so that the trihydro germane compound is efficiently constructed. Further, coupling of an olefin precursor and a germanium source is realized based on a metal-free condition or a zirconium-catalyzed olefin hydrogen germanization reaction, so that dihydrogermane and monohydrogen germane compounds are synthesized. The germane compound obtained by the invention can be separated and purified by conventional means such as extraction, column chromatography and the like, is stable to air and humidity, and shows a good industrial application prospect.

The invention provides a probe, a freeze-drying reagent, a lateral flow chromatography test strip, a kit and a method for detecting RNase activity, and relates to the technical field of biology. According to the present invention, based on the specific antigen-antibody reaction and the immunochromatography technology, the RNA probe with the 5'end labeled with digoxin and the 3 'end labeled with biotin is selected as the substrate, and under the condition that the sample to be detected contains RNase and is mixed with the substrate, the RNase can specifically recognize and cut the phosphodiester bond on the RNA probe so as to fragment the RNA; then, the test strip is inserted into the reacted reagent, if the sample does not contain RNase, the RNA probe is not subjected to enzyme digestion and can be fixed on the quality control line and combined with streptavidin, the quality control line shows a red strip, and the detection line does not develop color; if RNase exists in the sample, the RNA probe is fixed on the detection line after being subjected to enzyme digestion and is combined with the secondary antibody, and a red strip appears on the detection line.

The invention discloses a high-throughput screening synthesis method of an oxoisoindoline-carboxylic acid compound, which comprises the following steps: in a polar solvent, carrying out carbonyl insertion reaction on a compound as shown in a formula I in the presence of a Pd catalyst and alkali under a heating condition to obtain an oxoisoindoline-carboxylic acid compound as shown in a formula II, in the formula, X is CH2 or C = O, and Y is CH3 or H. The oxo-isoindoline-carboxylic acid compound is synthesized and constructed through high-throughput screening, a series of oxo-isoindoline-carboxylic acid compounds are obtained, and optimal reaction conditions are obtained in an extremely short time through proper high-throughput screening, so that the reaction conditions of high yield and high compatibility are quickly locked, and the yield of the oxo-isoindoline-carboxylic acid compound is greatly improved. The innovative breakthrough of the method in the aspect of reaction mechanism is more highlighted, and a solution capable of being popularized is provided for efficient synthesis of similar carboxylic acid derivatives.

The invention discloses a light response type self-adaptive interface bridging agent, a preparation method thereof and application of the light response type self-adaptive interface bridging agent in mixed plastic recovery, and belongs to the technical field of high polymer material recovery. The interface bridging agent is symmetrical in molecular structure, the two ends of the interface bridging agent are 3-(trifluoromethyl)-3H-diaziridine bridging end groups capable of generating carbene, and the middle part of the interface bridging agent comprises an azobenzene photosensitive driving unit and a self-adaptive connecting unit (such as a disulfide bond). The core of the method is that illumination with different wavelengths is utilized: under ultraviolet irradiation, azobenzene is isomerized into cis-conformation, internal stress is generated to promote bond breakage of a connecting unit, and self-adaptive network dissociation is realized; under the irradiation of visible light, the azobenzene recovers trans-conformation, and the connection unit bonds are recombined to realize network reconstruction. When the mixed plastic is recycled, the interface bridging agent can reinforce interface bonding through a carbene insertion reaction to form a'molecular rivet ', and dissociation and reshaping of the material are realized through light-operated reversible regulation and control. According to the invention, remote, reversible and accurate regulation and control of the material performance are realized, the process is mild, the recovery efficiency of the incompatible mixed plastic and the performance of the regenerated product are obviously improved, and the method has a good application prospect.

The invention belongs to the technical field of optical functional materials, and particularly relates to a polymer cross-linking agent, a preparation method thereof and application of the polymer cross-linking agent in organic electro-optical materials. The invention provides a polymer cross-linking agent which has a structure as shown in a formula I. A cross-linking group is introduced to a polymer cross-linking agent, the group can release nitrogen to generate reactive carbene under the condition of illumination (350-450 nm ultraviolet irradiation) or heating, the carbene is subjected to a cross-linking reaction with a polymer framework and a chromophore through a C-H bond insertion reaction, and a stable three-dimensional network structure is formed; the method is suitable for improving the glass transition temperature and thermal stability of various structural materials, and has universality and wide applicability. The technology provides a new way for developing flexible optoelectronic devices, and the low-energy-consumption and high-precision crosslinking characteristics of the flexible optoelectronic devices show wide prospects in the fields of wearable devices and integrated photonic chips.

The invention discloses a synthetic method of fluorine-containing polyester monomer dicarboxylic acid, which comprises the following steps: taking 2, 2-bis (4-aminophenyl) hexafluoropropane as a raw material, carrying out diazotization and Sandmeyer reaction to obtain an intermediate I, and then carrying out carbonyl insertion reaction to obtain 2, 2-bis (4-carboxyphenyl) hexafluoropropane, or carrying out cyanation reaction on the intermediate I to obtain an intermediate II, and then carrying out carbonyl insertion reaction to obtain 2, 2-bis (4-aminophenyl) hexafluoropropane. And hydrolyzing to obtain the 2, 2-bis (4-carboxyl phenyl) hexafluoropropane. The synthesis method disclosed by the invention is simple and easy to operate, high in yield and high in product purity, and can be applied to actual industrial production.

The invention belongs to the technical field of drug synthesis, and discloses a method and a device for judging an alfacalcidol chiral selection reaction endpoint. The end point judgment method comprises the following steps: (1) adding raw materials such as intermediate alfacalcidol and the like in prescription dosage into a reaction container according to a preset process; (2) inserting an optical rotation determination test tube into the reaction liquid through a hose, arranging a peristaltic pump on the hose, and placing the optical rotation determination test tube in a polarimeter; and (3) starting the peristaltic pump and the polarimeter, continuously measuring the optical rotation of the reaction liquid through the polarimeter, measuring each point for N times (N is greater than or equal to 3), taking an average value, recording average change values, and judging that the reaction endpoint is generated when the average value of the three average change values is less than 2. According to the method, the reaction device is creatively and directly combined with the polarimeter, the optical rotation change condition of the reaction liquid is measured in real time through the polarimeter, whether the synthetic reaction reaches the end point or not is indirectly judged accordingly, and the measuring method is accurate, high in efficiency and suitable for industrial production.

The utility model discloses a kind of reaction systems for organic peroxidation, belong to chemical experiment equipment technical field.It includes reaction unit and stirring unit, reaction unit includes reaction cavity, it is used to accommodate reactant in it, stirring unit inserts reaction cavity, the reactant in reaction cavity is stirred, further include foam collecting unit, the foam collecting unit includes foam collection chamber, foam drainage pipe and foam trapping tank, the foam collection chamber is fixed in reaction cavity inner wall, foam drainage pipe one end communicates foam collection chamber inside, foam drainage pipe other end connects foam trapping tank, wherein, the nozzle of foam drainage pipe is towards the notch of foam trapping tank, reaction end line is set on foam collection chamber.The utility model aims at accurate judgment reaction end.

The invention discloses an organic electro-optical material capable of being used for waveguide interface functionalization and a preparation method and application thereof.A 4-azido-2, 3, 5, 6-tetrafluorobenzene structural unit is introduced into the material, nitrogen-guene generated by the structure under ultraviolet irradiation can be subjected to an insertion reaction with C-H bonds in material molecules or on an interface, and the material can be used as a functional material for waveguide interface functionalization. A solid three-dimensional cross-linked network is formed, meanwhile, a plurality of polar groups and fluorine atoms are provided, interface wettability and physical and chemical bonding force between the material and common waveguide materials such as Si, Si3N4 and SiO2 can be improved, interlayer adhesive force and interface stability in a waveguide structure are remarkably improved, and the performance of the material is improved. And the failure problems of delamination, thermal warping and the like in preparation and long-term operation of the device are reduced.

The invention provides a preparation method of an inositol hexaphosphate kinase inhibitor, and provides a preparation method of a compound shown as a formula F. The reaction formula is shown as the following: # imgabs0 #, in which R1 is OMs, OTf, OTs, Cl, Br or I; comprising the following steps: (1) carrying out carbonyl insertion reaction on a compound A, ethanol and a CO source in the presence of a palladium catalyst and alkali to generate a compound B; (2) performing deprotection reaction on the compound B in a hydrochloric acid solution to generate a compound C; (3) in the presence of a reducing agent and an acid activator, carrying out reductive amination reaction on the compound C and a compound D to generate a compound E; (4) carrying out hydrolysis reaction on the compound E under an alkali condition to generate a compound F; the preparation method disclosed by the invention is simple and convenient to operate, high in yield, good in product quality, mild in reaction condition, easily available in raw materials, short in reaction time and suitable for industrial large-scale production.

The invention relates to the technical field of chemical pharmacy, and discloses a method for preparing a topramezone intermediate 3-(4, 5-dihydro-3-isoxazolyl)-2-methyl-4-(methylsulfonyl) benzoic acid, which comprises the following steps: S1, taking 3-(3-halo-2-methyl-6-(methylsulfonyl) phenyl)-4, 5-dihydroisoxazole as an initial raw material, and reacting at the temperature of 50-60 DEG C for 1-2 hours to obtain a topramezone intermediate 3-(4, 5-dihydro-3-isoxazolyl)-2-methyl-4-(methylsulfonyl) benzoic acid; under the catalysis of a metal catalyst, carrying out carbonyl insertion reaction on the intermediate carboxylic acid ester and formate to prepare an intermediate carboxylic acid ester; s2, the carboxylic ester is subjected to a hydrolysis reaction, and a target compound I, namely, 3-(4, 5-dihydro-3-isoxazolyl)-2-methyl-4-(methylsulfonyl) benzoic acid, is prepared. A target product is synthesized through a carbonyl insertion reaction and a two-step reaction, and the reaction steps are short. Compared with carbon monoxide, carbon monoxide is replaced by formate, so that the loss of carbon monoxide is reduced, the raw materials are easily available, the transportation and supply are convenient, and the reaction yield is better.

The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a fenerenone key intermediate, which comprises the following preparation steps: (1) carrying out dehydration reaction on 4-bromo-3-methoxybenzamide (I) to obtain 4-bromo-3-methoxybenzonitrile (II); and (2) carrying out reductive carbonyl insertion reaction on the 4-bromo-3-methoxybenzonitrile (II), so as to prepare the key intermediate 4-cyano-2-methoxybenzaldehyde (III) of the fenerenone. The synthetic route disclosed by the invention is short, the raw materials are easy to obtain, the reaction conditions are mild, and the method has the advantages of high yield, high product purity, safe and environment-friendly reaction materials and the like; the catalyst adopted in the invention is a catalyst containing heavy metal palladium, has a good catalytic effect, is easy to recover and reuse, and saves the cost.

The invention provides a preparation method of lornoxicam, which comprises the following steps: (1) reacting 2-bromothiophene-3-sulfonyl chloride with glycine methyl ester hydrochloride to obtain a compound 4; (2) reacting the compound 4 with a chlorination reagent to obtain a compound 5; (3) mixing the compound 5 with phenyl formate, a catalyst and a phosphorus ligand, and carrying out carbonyl insertion reaction to obtain a compound 6; (4) mixing and reacting the compound 6 with alkali to obtain a compound 7; (5) mixing and reacting the compound 7 with a methylation reagent to obtain a compound 8; and (6) mixing and reacting the compound 8 with 2-aminopyridine to obtain a compound 1, namely lornoxicam. By adopting the specific starting raw materials, the impurity content can be effectively reduced, the reaction yield is improved, meanwhile, the reaction condition is mild, a high-toxicity reagent does not need to be adopted, and the method is green and environmentally friendly.

The utility model relates to the technical field of reaction kettles, and provides a safety chemical reaction kettle which comprises a reaction kettle tank, a driving and stirring assembly arranged in the reaction kettle tank, and feeding and discharging assemblies arranged at the upper end and the lower end of the reaction kettle tank; the driving stirring assembly comprises an output unit, the output end of the output unit is inserted into the reaction kettle tank and connected with a stirring shaft, a connecting block is arranged at the bottom of the stirring shaft, arc-shaped stirring blades are arranged on the two opposite sides of the connecting block, a connecting frame is arranged at the inner top of the reaction kettle tank, and the stirring shaft is sleeved with the connecting frame. According to the technical scheme, the problems that in the prior art, raw materials in a reaction kettle are heavy, eccentric jumping is easily generated during processing of the reaction kettle, a stirring shaft of the reaction kettle cannot be located at the same point for stirring, if the problem is ignored for a long time, the stirring function of the reaction kettle is damaged, and the stirring effect is poor are solved. The inclination angle of the stirring shaft is large, so that the interior of the reaction kettle is easy to collide and damage.

The invention discloses a preparation method of an alkene liquid crystal monomer. The preparation method comprises the following steps: (1) carrying out esterification reaction on trans-2-butenol and a chlorophosphate compound to obtain a phosphate compound intermediate A; and (2) carrying out a metal insertion reaction on dicyclohexyl-substituted alkyl halide B and magnesium to generate a Grignard reagent, and coupling the generated Grignard reagent with the phosphate compound intermediate A obtained in the step (1) to prepare the alkene liquid crystal monomer C containing dicyclohexyl and trans-substituted alkenyl. According to the invention, a phosphate compound intermediate A with a trans-ene structure is prepared from an existing easily available material, namely trans-2-butenol, and then the phosphate compound intermediate A and a Grignard reagent prepared from dicyclohexyl-substituted alkyl halide B are subjected to a coupling reaction to directly form a target product with a high-content trans-ene structure. The problems of high product purification difficulty, low yield and the like caused by multi-step recarburization and cis-alkene structure isomerization in the prior art are effectively avoided.

The invention belongs to the technical field of catalyst preparation and organic synthesis, and particularly discloses a cobalt-nickel bimetallic catalyst and a preparation method and application thereof.According to the cobalt-nickel bimetallic catalyst, silicon dioxide serves as a carrier, and cobalt and nickel bimetallic active components with the molar ratio being 1: 2-2: 1 are evenly loaded; the catalyst is prepared through silica template pretreatment, mixing of a cobalt source and a nickel source and reduction of a reducing agent, and is simple to synthesize, low in cost and recyclable. The catalyst is applied to preparation of dimethyl 2, 6-naphthalate, 6-hydroxy-2-naphthoic acid which is easy to obtain and low in cost can be used as a starting raw material, a target product can be obtained through esterification, hydroxyl protection and carbonyl insertion, the conversion rate of the carbonyl insertion reaction can reach 90.1%, aftertreatment and purification are simple, the product purity is larger than or equal to 99.90%, and the catalyst is suitable for industrial production. And the cobalt-nickel bimetallic catalyst can be recycled, so that the production cost is remarkably reduced, the production period is remarkably shortened, the industrial application prospect is very strong, and a foundation is laid for industrialization of the PEN material.

The invention relates to carbon-14 labeled benzaldehyde and a preparation method and application thereof.The preparation method comprises the steps that 14C-BaCO3 is converted into 14C-CO2, then 14C-CO2 and a phenyl Grignard reagent are subjected to an insertion reaction to synthesize 14C-benzoic acid, and 14C-benzaldehyde is synthesized from 14C-benzoic acid through a method that the 14C-benzoic acid is firstly reduced and then oxidized. The carbon-14 labeled benzaldehyde provided by the invention can be used as a radioactive tracer for drug metabolism research, and the provided preparation method has the advantages of high utilization efficiency of a carbon-14 source material and high reaction yield; the product is easy to separate and high in purity; in the reaction process, abundance of carbon isotopes cannot be diluted, the specific activity of the product is high, and the method has high application value.

The invention relates to a synthetic compound comprising (a.) one or more crosslinkable groups and one or more cleavable groups, (b.) wherein at least one crosslinkable group forms a covalent bond with a C-H group by a C,H insertion reaction upon an external stimulation, (c.) wherein at least one crosslinkable group is covalently bound to at least one cleavable group, and (d.) wherein a covalent bond of the cleavable group is cleavable upon an external stimulation. The invention further relates to an oligomer composite comprising the synthetic compound, a method for producing said oligomer composite and a method for cleaving said oligomer composite.

The invention provides a synthetic method of a bromopyridine intermediate for preparing loratinib. The synthetic method comprises the following steps: S1, carrying out substitution reaction on a compound 3 and a compound 8 to obtain a compound 9; s2, the compound 9 is subjected to a palladium-catalyzed carbonyl insertion reaction, and a compound 7, namely the loratinib key intermediate, is obtained; compared with the traditional route, the route provided by the invention has the advantages that the raw material structure has bromine, the main route is shortened, the target molecular compound 7 is obtained after carbonyl insertion, the total yield is high, the route is simple, and the cost is greatly reduced. Therefore, the innovative process has great economic value.