10 results about "Insertion reaction" patented technology

The invention relates to a method for preparing a cycloheptatrienone derivative, and belongs to the technical field of bioengineering. The invention provides a method for preparing a cycloheptatrienone derivative, which is based on a framework editing strategy of biological catalysis and comprises the following steps of: performing biological catalysis on a substrate and an auxiliary substrate by using a phenol derivative as a substrate and nitroalkane as an auxiliary substrate and using multi-copper oxidase and / or a microorganism for producing the multi-copper oxidase as a catalyst to obtain the cycloheptatrienone derivative. The auxiliary substrate is used as a C1 unit to be inserted into the skeleton of the aromatic ring substrate for editing, so that the cycloheptatrienone derivative is generated. According to the method, multi-copper oxidase is used as a catalyst, nitroalkane which is simple, easy to obtain, safe and highly stable is used as a C1 unit, and a phenol derivative is successfully converted into the cycloheptatrienone derivative. According to the method, a single carbon insertion mediated skeleton editing biological catalysis strategy is constructed, the strategy breaks through the limitation of a traditional carbene insertion reaction, and the method has a great application prospect in skeleton modification in the field of chemical and biological catalysis.

The application discloses a dicarboxylic acid-quaternary ammonium salt synergistic catalytic system and application thereof in carbon dioxide and epoxide reaction. The catalytic system comprises a dicarboxylic acid compound and a quaternary ammonium salt, wherein the dicarboxylic acid serves as a hydrogen bond donor, the quaternary ammonium salt provides a nucleophilic anion, and both of them synergistically promote epoxide activation and carbon dioxide insertion reaction. The dicarboxylic acid preferably has a first dissociation constant pKa1 of 4.0-7.0, and the quaternary ammonium salt is preferably a bromide or iodide tetraalkylammonium salt. In the presence of the catalytic system, carbon dioxide can be efficiently reacted with various epoxides under relatively mild conditions to generate corresponding cyclic carbonates. The catalytic system has the advantages of simple structure, no metal, high catalytic efficiency, wide substrate application range and the like, and has a good industrial application prospect.

The invention provides a trihydrogermane, a dihydrogermane, a monohydrogermane, and a method for preparing the trihydrogermane, the dihydrogermane and the monohydrogermane. Germanium dichloride is used as an initial raw material, and is subjected to an insertion reaction with a carbon halogen bond of halogenated hydrocarbon, and then reduction treatment is performed, so that the trihydro germane compound is efficiently constructed. Further, coupling of an olefin precursor and a germanium source is realized based on a metal-free condition or a zirconium-catalyzed olefin hydrogen germanization reaction, so that dihydrogermane and monohydrogen germane compounds are synthesized. The germane compound obtained by the invention can be separated and purified by conventional means such as extraction, column chromatography and the like, is stable to air and humidity, and shows a good industrial application prospect.

The utility model discloses a kind of reaction systems for organic peroxidation, belong to chemical experiment equipment technical field.It includes reaction unit and stirring unit, reaction unit includes reaction cavity, it is used to accommodate reactant in it, stirring unit inserts reaction cavity, the reactant in reaction cavity is stirred, further include foam collecting unit, the foam collecting unit includes foam collection chamber, foam drainage pipe and foam trapping tank, the foam collection chamber is fixed in reaction cavity inner wall, foam drainage pipe one end communicates foam collection chamber inside, foam drainage pipe other end connects foam trapping tank, wherein, the nozzle of foam drainage pipe is towards the notch of foam trapping tank, reaction end line is set on foam collection chamber.The utility model aims at accurate judgment reaction end.

The invention belongs to the technical field of catalyst preparation and organic synthesis, and particularly discloses a cobalt-nickel bimetallic catalyst and a preparation method and application thereof.According to the cobalt-nickel bimetallic catalyst, silicon dioxide serves as a carrier, and cobalt and nickel bimetallic active components with the molar ratio being 1: 2-2: 1 are evenly loaded; the catalyst is prepared through silica template pretreatment, mixing of a cobalt source and a nickel source and reduction of a reducing agent, and is simple to synthesize, low in cost and recyclable. The catalyst is applied to preparation of dimethyl 2, 6-naphthalate, 6-hydroxy-2-naphthoic acid which is easy to obtain and low in cost can be used as a starting raw material, a target product can be obtained through esterification, hydroxyl protection and carbonyl insertion, the conversion rate of the carbonyl insertion reaction can reach 90.1%, aftertreatment and purification are simple, the product purity is larger than or equal to 99.90%, and the catalyst is suitable for industrial production. And the cobalt-nickel bimetallic catalyst can be recycled, so that the production cost is remarkably reduced, the production period is remarkably shortened, the industrial application prospect is very strong, and a foundation is laid for industrialization of the PEN material.

This invention provides a method for the rearrangement nitrogen insertion reaction of indole phosphonium salts and tert-butyl (p-toluenesulfonyloxy) carbamate under potassium carbonate-promoted conditions, synthesizing a series of 3-aminoindole compounds. The technical solution of this invention has the following significant advantages: it eliminates the need for expensive metal catalysts, significantly reducing production costs; the reaction conditions are mild and simple, and the reaction can be carried out efficiently at room temperature with only the addition of a base and an amine source, achieving excellent chemoselectivity, regioselectivity, broad functional group compatibility, and excellent atom economy.

The invention discloses a method for preparing chiral lactam from prochiral ketone, and belongs to the technical field of chemical synthesis. According to the method, chlorobenzene or toluene or a chlorobenzene / diethyl ether mixed solution is used as a solvent, under the action of a chiral catalyst, prochiral cyclic ketone and sulfonyl hydroxylamine are subjected to a desymmetrical nitrogen atom insertion reaction at-78 DEG C to 25 DEG C, high-stereoselectivity chiral lactam is prepared in one step, and the reaction time is 2-8 h. The method has the advantages that the raw materials are low in price and easy to obtain, the chiral catalyst is commercially available and small in dosage, the product has excellent stereoselectivity, post-treatment is simple and convenient, and a novel green and economical way with wide industrial application prospects is provided for synthesis of chiral drugs and fine chemicals.

A system for monitoring the alkalinity of a treatment liquid in a treatment tank includes a reaction tank; an indicator burette which drops an indicator into the reaction tank; a reagent burette which drops an acidic reagent into the reaction tank; a probe-type absorptiometer to be inserted into the reaction tank; a measuring device which analyzes the transmittance of a solution detected by the absorptiometer to calculate the alkalinity; a first system that collects the treatment liquid from the treatment tank for storing and supplies the treatment liquid to the reaction tank; a control device which controls the operation of the first system so as to supply the treatment liquid to the reaction tank, outputs a completion signal to the measuring device, and controls a discharge system so as to discharge the treatment liquid in the reaction tank, when the calculation of alkalinity by the measuring device is completed.

The invention relates to a degradable copolyester, a monomer used by the degradable copolyester and a preparation method of the monomer, and the preparation method of the monomer comprises the following steps: adding protonic acid, halide and a compound as shown in a formula (1) into an organic solvent, carrying out heating reaction under a protective atmosphere, and after the reaction is finished, separating to obtain an intermediate product as shown in a formula (2); and adding the intermediate product, an alkaline compound, a transition metal catalyst and a phosphine ligand into a solvent, introducing CO, carrying out a heating reaction, and after the reaction is finished, carrying out separation to obtain the monomer as shown in a formula (3). According to the method, the monomer based on the terephthalic acid and propyl alcohol ester and shown in the formula (3) can be obtained through the halogenation reaction and the carbonyl insertion reaction, the raw materials used in the reaction are low in cost and safe, the reaction conversion rate, selectivity and stability are high, and the product is easy to purify and separate.

The application belongs to the technical field of optical functional materials, and particularly relates to a polymer crosslinking agent, a preparation method thereof and application thereof in organic electro-optical materials. The application provides a polymer crosslinking agent with a structure shown in formula I. The application introduces a crosslinking group on the polymer crosslinking agent. The group can release nitrogen to generate a reactive carbene under light (350-450 nm ultraviolet light irradiation) or heating. The carbene is inserted into a C-H bond to react with a polymer framework and a chromophore to form a stable three-dimensional network structure. The application is suitable for improving the glass transition temperature and thermal stability of various structural materials, and has universality and wide applicability. The technology provides a new way for developing flexible optoelectronic devices, and the low-energy-consumption and high-precision crosslinking characteristics have broad prospects in the fields of wearable devices and integrated photon chips.