Wound suturing-free tissue adhesive

A tissue glue and wound technology, applied in the field of medical and sanitary materials, can solve the problems of accelerating the polymerization reaction of tissue glue, prolonging the polymerization time of tissue glue polymer film, and low solubility

Inactive Publication Date: 2006-10-25
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned added antibacterial agent, deodorant have the following disadvantages: 1. under room temperature (being 20-25 ℃) in solubility in α-cyanoacrylate alkyl ester; 3. Accelerate the polymerization of tissue glue on the skin wound, so that it is too late to apply the tissue glue to the entire wound; 4. Prolong the appropriate polymerization time of the tissue glue polymer film on the skin wound and other shortcomings

Method used

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  • Wound suturing-free tissue adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] The composition and content of the wound suture-free tissue glue of the present invention are as follows:

[0044] Alpha-amyl cyanoacrylate 10

[0045] Decyl alpha-cyanoacrylate 20

[0046] Polybutylmethacrylate 0.5

[0047] Dibutyl phthalate 1.0

[0048] Angelica essential oil 0.05

[0049] Chlorhexidine Iodine 0.1

[0050] The preparation method of the wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above-mentioned components according to their contents.

Embodiment 2

[0052] The composition and content of the wound suture-free tissue glue of the present invention are as follows:

[0053] α-Ethyl cyanoacrylate 40

[0054] Polyethylmethacrylate 2

[0055] Polyoctyl methacrylate 0.5

[0056] Diethyl phthalate 1.0

[0057] Dibutyl phthalate 1.0

[0058] Angelica essential oil 0.4

[0059] Cinnamon oil 0.6

[0060] erythromycin ethylsuccinate 0.5

[0061] Acetylspiramycin 0.5

[0062] The preparation method of the wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above-mentioned components according to their contents.

Embodiment 3

[0064] The composition and content of the wound suture-free tissue glue of the present invention are as follows:

[0065] α-Ethyl cyanoacrylate 20

[0066] α-Propyl cyanoacrylate 20

[0067] α-Butyl cyanoacrylate 20

[0068] n-octyl alpha-cyanoacrylate 20

[0069] PMMA 2.5

[0070] Polyethylmethacrylate 2.5

[0071] Polyvinyl acetate 2.5

[0072] Diethyl phthalate 1.5

[0073] Dibutyl phthalate 2.5

[0074] Di-n-octyl phthalate 1

[0075] Dipropyl sebacate 1.5

[0076] Angelica essential oil 6

[0077] Cinnamon Oil 5

[0078] Myrrh Essential Oil 2

[0079] Pioneer metabolite 7

[0080] Cefixime 6

[0081] Tobramycin 6

[0082] Erythromycin 3.5

[0083] The preparation method of the wound suture-free tissue glue of the present invention is obtained by uniformly mixing the above-mentioned components according to their contents.

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Abstract

The present invention relates to a wound non-suturing tissue glue, in the concrete, it relates to an alkyl alpha-cyanoacrylate tissue glue containing anti-bacterial agent and deodorant. Its composition contains 40.0-85.0 portions of alkyl alpha-cyanoacrylate, 0.7-6.5 portions of strength improving agent, 0.5-7.5 portions of plasticity improving agent, 0.1-22.5 portions of anti-bacterial agent and 0.02-9.5 portions of deodorant. The anti-bacterial agent can be one or more than two kinds of cefmetazole, erythromycin ethylsuccinate, acetylspiramycin and chlorhexidine iodine and the deodorant can be one or more than two kinds of Chinese angelica root essential oil, cinnamon oil and myrrh essential oil.

Description

technical field [0001] The invention belongs to the field of medical and sanitary materials, and in particular relates to an α-cyanoacrylate alkyl ester wound-free tissue glue containing high-efficiency antibacterial components and deodorizing components. Background technique [0002] Surgical and traumatic wounds are usually closed using three methods: sutures, staples, and tissue glue. [0003] Tissue glue bonding method, that is, α-alkyl cyanoacrylate tissue glue closing wound method, has unique characteristics of bonding wounds. α-Alkyl cyanoacrylate tissue glue is widely used as a seam-free tissue glue to close surgical wounds and traumatic wounds, especially for wounds that are difficult to close satisfactorily with suture, it saves time and energy, and can bond difficult-to-suture wounds. tissue, can provide a relatively airtight environment for wound closure, no need to change dressings after surgery, has the effect of hemostasis, the wound is more beautiful after h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10
Inventor 樊粤光孙鸿涛阮传良王海彬
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU UNIV OF CHINESE MEDICINE
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