Water-based tissue adhesives

An adhesive, water-based solvent technology, used in adhesives, surgical adhesives, bandages, etc., can solve problems such as expensive, cumbersome production and preparation processes, weak tissue adhesion, etc.

Active Publication Date: 2020-07-07
阿莱奥生物医学工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These disadvantages include poor tissue adhesion in moist environments, risk of viral transmission and allergic reactions, and costly and cumbersome production and preparation processes

Method used

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  • Water-based tissue adhesives
  • Water-based tissue adhesives
  • Water-based tissue adhesives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0215] Embodiment 1. An adhesive composition comprising:

[0216] aqueous solvents; and

[0217] First class of nanoparticles dispersed in aqueous solvents

[0218] wherein the first type of nanoparticles is negatively or positively charged; and

[0219] Wherein the first type of nanoparticles has a three-dimensional average particle diameter of 1 nm to 1000 nm.

Embodiment approach 2

[0220] Embodiment 2. The nanoparticles in the composition of embodiment 1 are spherical or nearly spherical.

Embodiment approach 3

[0221] Embodiment 3. The first type of nanoparticles in the composition of embodiment 1 has an average zeta potential of less than -30 mV or greater than 30 mV.

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Abstract

An adhesive composition described herein comprises an aqueous solvent; and a population of first nano particles dispersed in the aqueous solvent, the first nano particles comprising a negative or positive charge, and an average size in three dimensions of 1 nm to 1000 nm. In some embodiments, a population of second nano particles is dispersed in the aqueous solvent, the second nano particles comprises a negative or positive charge opposite the charge of the population of first nano particles. In some embodiments, the population of first nano particles comprises an average first size in three dimensions, and the population of second nano particles comprise an average second size in three dimensions that is different from the average first size of the first nano particles.

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C. §119 to U.S. Provisional Patent Application 62 / 566,730 filed on October 2, 2017 and U.S. Provisional Patent Application 62 / 664,739 filed on April 30, 2018. technical field [0003] The present disclosure relates to water-based adhesives, and more particularly, the present disclosure relates to water-based tissue adhesives. Background technique [0004] Traditional bioglues, especially those derived from industrial uses, e.g. based on cyanoacrylates and based on polyurethane Tissue adhesives usually undergo violent chemical reactions during use. Because of the inherent exothermic properties of chemical reactions, this type of bioglue has the risk of tissue damage. Today's research hotspot is to develop a substitute for this type of industrial adhesive, which must have the characteristics of using milder physical and chemical reactions to carry out crosslinking and tis...

Claims

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Application Information

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IPC IPC(8): A61L15/18A61L15/22A61L15/44
CPCA61K8/00A61L15/58A61L24/001A61L2400/12A61L15/585C09J201/00
Inventor 刘超郭金山陈晨约翰·杰·朗德宋巍
Owner 阿莱奥生物医学工程有限公司
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