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Polyphenol-based medical tissue adhesive as well as preparation method and application thereof

An adhesive, polyphenol-based technology, applied in the field of biomedical material preparation and biomedical application, can solve the problems of low bonding strength, pro-inflammatory and immunogenicity, inability to be widely used, poor biocompatibility, etc. To achieve the effect of easy control of process parameters, promotion of tissue healing, and improvement of hemostatic properties

Pending Publication Date: 2022-04-19
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former usually have excellent biocompatibility and biodegradability, but are expensive, have low bond strength, and are potentially pro-inflammatory and immunogenic, which to some extent prevents their widespread use.
The latter has high bonding strength, but poor biocompatibility, and may also have problems such as cytotoxicity, chronic inflammation, and difficulty in degrading in vivo

Method used

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  • Polyphenol-based medical tissue adhesive as well as preparation method and application thereof
  • Polyphenol-based medical tissue adhesive as well as preparation method and application thereof
  • Polyphenol-based medical tissue adhesive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A. Weigh 1g of tannic acid and 2g of polyethylene glycol (20000Da) according to the mass ratio of 1:2, pour them into a weighing bottle respectively, add Tris-Hcl buffer solution and stir for 10h to obtain a concentration of 50wt% tannic acid solution and a polyethylene glycol solution with a concentration of 12wt%, the two solutions were mixed, stirred at 400r / min for 3h, and the temperature was controlled at 60°C to react to obtain a tannic acid-polyethylene glycol complex.

[0030] B. Weigh 0.08g of bioactive glass powder and add it to the compound of step A, stir at 400r / min for 2h, and control the temperature at 60°C to prepare a polyphenol-based medical tissue adhesive. After testing, conventional shear The shear strength is 227.8KPa, and the bonding strength of pigskin is 28.2KPa, which can quickly and effectively achieve hemostasis and adhesion of wounds in a blood environment within 5s.

Embodiment 2

[0032] A. Weigh 1g of tannic acid and 10g of polyethylene glycol (70000Da) according to the mass ratio of 1:1, pour them into a weighing bottle respectively, add Tris-Hcl buffer solution and stir for 10h to obtain a concentration of 50wt% tannic acid solution and a polyethylene glycol solution with a concentration of 8wt%, the two solutions were mixed, stirred at 400r / min for 3h, and the temperature was controlled at 60°C to react to obtain a tannic acid-polyethylene glycol complex.

[0033] B. Weigh 0.08g of hydroxyapatite powder and add it to the compound of step A, stir at 400r / min for 2h, and control the temperature at 60°C to prepare a polyphenol-based medical tissue adhesive. After testing, conventional The shear strength is 168.1KPa.

Embodiment 3

[0035] (1) Firstly, the self-assembly between polyphenolic compounds and polyethylene glycol molecules is used to construct a primary network structure (hydrogen bond network), and then inorganic nanoparticles are introduced into the adhesive formula to construct a secondary network structure (ionic bond network).

[0036] (2) The specific preparation steps of a polyphenol-based medical tissue adhesive are as follows:

[0037] A. Weigh polyphenolic compounds and polyethylene glycol in proportion (the mass ratio of polyphenolic compounds to polyethylene glycol is 1:10 to 10:1), dissolve them in water or Tris-HCl buffer solution respectively, and prepare Form a solution of a certain concentration, mix evenly, heat and stir, the speed is 200-500rpm / min, the temperature range of the water bath is 20-60°C, the reaction time is 1-3h, the concentration of the polyphenol compound solution is 30-50wt%, polyethylene glycol The concentration of the alcohol solution is 8-50 wt %, the mol...

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Abstract

The invention discloses a polyphenol-based medical tissue adhesive as well as a preparation method and application thereof, and belongs to the field of biomedical material preparation and biomedical application. The adhesive is prepared from a polyphenol compound solution, inorganic nanoparticles and a polyethylene glycol solution under specific conditions. The prepared polyphenol-based medical adhesive has the characteristics of high bonding strength, excellent hemostasis and antibacterial property, good oxidation resistance, safety, no toxicity, good biocompatibility, low price and the like, is simple and easy to use and operate, can be used for most damaged tissues such as skin, blood vessels, visceral organs, muscles, bones and the like, and has the advantages of wide application prospect and the like. The adhesive has the effects of adhering tissues, covering wounds, stopping bleeding, resisting bacteria, resisting oxidation and the like, can be used as a hemostatic, antibacterial and antioxidant adhesive material, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the fields of biomedical material preparation and biomedical application, and specifically relates to a polyphenol-based medical tissue adhesive with high bonding strength and excellent biological functionality, a preparation method and application thereof. Background technique [0002] People inevitably encounter trauma or disease damage in production and life, and it is easy to form open wounds, exposing sensitive tissues to physical, chemical and pathogenic attacks. Without proper treatment, these wounds may be infected by microorganisms and delay wound healing , and may even lead to tissue necrosis. In traditional medicine, sutures are generally used for tissue repair, which requires complicated operations and is prone to wound infection during the later process of suture removal, which hinders wound healing and even becomes a burden for patients. With the development and progress of modern medical science and technology, ...

Claims

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Application Information

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IPC IPC(8): C09J171/02C09J11/04C09J11/06A61L15/18A61L15/20A61L15/26A61L15/42A61L15/44A61L15/46A61L24/00A61L24/02A61L24/04
CPCC09J171/02C09J11/04C09J11/06A61L24/046A61L24/02A61L24/001A61L24/0015A61L15/26A61L15/18A61L15/20A61L15/42A61L15/44A61L15/46C08K2003/325C08K2201/011A61L2400/12A61L2300/404A61L2400/04A61L2300/40A61L2300/412A61L2300/216C08K5/1545C08K3/40C08K3/32C08L71/02
Inventor 鲁玺丽李一波贺乔柏孟鑫鑫
Owner HARBIN ENG UNIV
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