Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

A medical absorbable polysaccharide composite material and its application

A composite material and polysaccharide technology, applied in the field of medical materials, can solve problems such as the formation of effective hemostasis at difficult bleeding points, the performance of limiting water absorption, and the inability to effectively block bleeding points, so as to achieve materials for promoting tissue healing and good biological properties. Capacitive and degradable properties, the effect of accelerating the rate of water absorption

Active Publication Date: 2021-05-28
济南格莱威医疗科技有限公司
View PDF12 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The process used in this type of product is emulsification and cross-linking. Starch and modified starch are cross-linked to form a porous material, which can absorb water in the blood and accelerate the process of hemostasis. However, this type of product has three common disadvantages: (1) Cross-linking The porous material formed after is a network structure, which limits its ability to absorb water, and the water absorption rate is low; (2) because it is a network particle, the strength or viscosity of the gel formed after absorbing water or after hemostasis is too small to be able to It can effectively block the bleeding point, and it is easy to cause secondary bleeding in the actual application of hemostasis; (3) The porous material formed after cross-linking has a small density and is light. When sprayed on the bleeding wound, it will float on the blood surface of the bleeding point and is not easy to reach Bleeding points form effective hemostasis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A medical absorbable polysaccharide composite material and its application
  • A medical absorbable polysaccharide composite material and its application
  • A medical absorbable polysaccharide composite material and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of polysaccharide composite material, comprises potato starch and carboxymethyl starch, and carboxymethyl starch is made through etherification denaturation by original starch (potato starch), and potato starch and carboxymethyl starch are mixed uniformly, and wherein potato starch The weight ratio is 30%, and the rest is carboxymethyl starch. The mixture is graded and screened to prepare a composite polysaccharide hemostatic material. The particle size of the material is 1-800 μm, and the weight percentage of particles of 20-400 μm is not less than 85% of the total particle weight, more preferably the particle size is 30-200 μm.

Embodiment 2

[0033] A kind of polysaccharide composite material, comprises potato starch and carboxymethyl starch, and carboxymethyl starch is made through etherification denaturation by native starch (potato starch), and potato starch and carboxymethyl starch are mixed uniformly, wherein the potato starch The weight ratio is 50%, and the rest is carboxymethyl starch. The mixture is graded and screened to prepare a composite polysaccharide hemostatic material. The particle size of the material is 1-800 μm, and the weight percentage of particles of 20-400 μm is not less than 85% of the total particle weight, more preferably the particle size is 30-200 μm.

Embodiment 3

[0035] A polysaccharide composite material, including potato starch and carboxymethyl cellulose, carboxymethyl cellulose is made by etherification denaturation of cellulose, the potato starch and carboxymethyl cellulose are mixed evenly, wherein the potato starch accounts for The weight ratio is 40%, and the rest is carboxymethyl cellulose, and the mixture is graded and screened to prepare a composite polysaccharide hemostatic material. The particle size of the material is 1-800 μm, and the weight percentage of particles of 20-400 μm is not less than 85% of the total particle weight, more preferably the particle size is 30-200 μm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
viscosityaaaaaaaaaa
particle diameteraaaaaaaaaa
water absorptionaaaaaaaaaa
Login to View More

Abstract

The invention discloses a medical absorbable polysaccharide composite material and its application. In the present invention, a starch with poor water absorption is used as a material in the polysaccharide composite material, and a polysaccharide material with good water absorption is added in addition, without cross-linking reaction (direct mixing, or adding water and mixing evenly and then freeze-drying) ) to obtain a composite polysaccharide material. The material has the advantages of high water absorption rate, fast water absorption speed, higher gel strength and good biocompatibility, etc. It can directly act on blood wounds, including hemostasis on the surface of the body, the tissues and organs in the body and the body cavity. Hemostasis is quick and fast, can be absorbed by the human body, and has a viscous blocking effect. The material can be further used as post-operative anti-adhesion material, tissue-healing-promoting material, surgical sealant, wound-free tissue glue, tissue filling material, and tissue debridement material.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to a medical absorbable polysaccharide composite material and its application. Background technique [0002] Bleeding and oozing of surgical wounds are often encountered problems in surgery, and surgical blood loss can cause a large number of complications, even life-threatening. In recent years, medical absorbable materials have attracted great attention from the medical and industrial circles of various countries. The following types of absorbable materials are used clinically: [0003] 1. Chitosan material [0004] Including chitosan hemostatic powder, chitosan hemostatic sponge, chitosan hemostatic accessories, etc. Medical chitosan is mostly made of marine organisms such as shrimp shells and crab shells through decalcification, deproteinization, deacetylation, and carboxymethyl modification. Chitosan-based hemostatic products have low water absorption, are positively charged...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00A61L27/20A61L27/58A61L31/04A61L31/14
CPCA61L24/0042A61L24/08A61L27/20A61L27/58A61L31/042A61L31/148A61L2400/04C08L3/02C08L3/04C08L1/286C08L5/08
Inventor 左立祝伟伟姜丽娟张立伟宋祥路金荣
Owner 济南格莱威医疗科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com