Preparation method of degradable tissue glue based on polylactic acid and polycaprolactone copolymer

A polycaprolactone and copolymer technology, which is applied in the field of tissue glue manufacturing, can solve the problems of non-biodegradation and toxicity, and achieve the effects of high peel strength, good viscoelasticity and stickiness, and good biocompatibility

Inactive Publication Date: 2020-09-18
SHANDONG ZHUSHI PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, Histoacryl, the tissue glue currently used clinically, has certain toxicity and is not biodegradable.
[0006] The tissue glue that has been used clinically at present is Histoacryl glue (monomer N-butyl-2-acrylic acid cyanide) developed by Braun Medical Group in Germany. After contacting with human tissue fluid, it quic

Method used

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  • Preparation method of degradable tissue glue based on polylactic acid and polycaprolactone copolymer
  • Preparation method of degradable tissue glue based on polylactic acid and polycaprolactone copolymer
  • Preparation method of degradable tissue glue based on polylactic acid and polycaprolactone copolymer

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Embodiment Construction

[0027] Embodiments of the technical solutions of the present invention are described in detail below. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and therefore are only examples, rather than limiting the protection scope of the present invention.

[0028] Degradable tissue glue based on polylactic acid and polycaprolactone copolymer, the component of the degradable tissue glue is the copolymer, and the chemical molecular structure of the copolymer is:

[0029]

[0030] Where n and m are both natural numbers greater than or equal to 1.

[0031] Preferably, the degradable tissue glue preparation method based on polylactic acid and polycaprolactone copolymer is characterized in that: its preparation steps are as follows:

[0032] S1: Synthesis of PCL / PLA copolymer by bulk ring-opening polymerization of ε-caprolactone and DL-lactide under high temperature and vacuum conditions;

[0033] S2: Purification of ...

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Abstract

The invention relates to the technical field of tissue glue manufacturing, in particular to a preparation method of degradable tissue glue based on polylactic acid and polycaprolactone copolymer. Thepreparation method comprises the following steps: S1, synthesizing PCL/ PLA copolymer through bulk ring-opening polymerization reaction of epsilon-caprolactone and DL-lactide under high-temperature and vacuum conditions; and S2, purifying the PCL/ PLA copolymer. The copolymer has a double-sided bonding effect in actual use, has good biocompatibility, can play a bonding role within a certain time,has good viscoelasticity and holding power, and has high peel strength. The copolymer has a double-sided bonding effect in actual use, has good biocompatibility, can play a bonding role within a certain time, and has good viscoelasticity and holding power, and high peel strength.

Description

technical field [0001] The invention relates to the technical field of tissue glue production, in particular to a preparation method for degradable tissue glue based on polylactic acid and polycaprolactone copolymer. Background technique [0002] Biomaterials are a class of materials used for diagnosis, treatment, and repair, replacement, and reconstruction of body cells, tissues, and organs. They are widely used in the preparation of medical devices, organ repair, artificial organs, interventional medical products, and drug release systems. It is directly related to people's health and quality of life, and has important social significance and economic benefits. In 2019, the world medical device market is estimated to exceed 450 billion US dollars, of which biological materials and products account for about half. With the aging of the population, the improvement of people's requirements for the quality of life, and the need for new medical technologies, the international ...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/00C08G63/08C08G63/85
CPCA61L24/001A61L24/0042A61L24/046C08G63/08C08G63/823C08L67/04
Inventor 朱坤福李速明祝蕾朱俊辉
Owner SHANDONG ZHUSHI PHARMA GRP CO LTD
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