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Variable cross-section porous strip-shaped suture line for promoting tendon healing and preparation method thereof

A suture thread with variable cross-section technology, which is applied in the field of biomedical repair materials, can solve the problems of unfavorable cell adhesion and value addition, failure to achieve tendon healing, easy to cause inflammation and infection, etc., to achieve easy promotion, improve affinity, and reduce cumbersomeness Effect

Active Publication Date: 2020-08-14
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to solve the technical problems that the current sutures used for tendon repair easily cause secondary damage to the tissue, cannot achieve true tendon healing, are not conducive to cell adhesion and proliferation, and easily cause inflammation and infection

Method used

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  • Variable cross-section porous strip-shaped suture line for promoting tendon healing and preparation method thereof
  • Variable cross-section porous strip-shaped suture line for promoting tendon healing and preparation method thereof
  • Variable cross-section porous strip-shaped suture line for promoting tendon healing and preparation method thereof

Examples

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preparation example Construction

[0030] A preparation method of a variable cross-section porous strip-shaped suture for promoting tendon healing, comprising the following steps:

[0031] Step 1: Using two or more fiber materials, with the help of two-dimensional and three-axial weaving technology, and adjusting the weaving process to obtain a prefabricated suture thread with thin lines at both ends and a porous belt in the middle;

[0032] Step 2: obtaining a structurally stable variable cross-section porous ribbon suture through a heat treatment process;

[0033] Step 3: cleaning and drying the suture, and then performing hydrophilic activation pretreatment to obtain surface-activated suture;

[0034] Step 4: dissolving at least one natural polymer material in a corresponding solvent to obtain a polymer solution, then soaking the activated suture in the above solution for 1 hour and then freeze-drying, repeating 3 times to obtain a freeze-dried sample;

[0035] Step 5: Prepare a tannic acid cross-linking ag...

Embodiment 1

[0045] A variable cross-section porous ribbon suture for promoting tendon healing, comprising such as figure 1 The specific steps for the preparation of the three-section variable-section suture and the hydrogel coating shown are as follows:

[0046] Step 1: Select 55.0dtex ultra-high molecular weight polyethylene multifilament as the braiding yarn 4, 110.0dtex polycaprolactone multifilament as the shaft yarn 5, and then prepare sutures by two-dimensional three-axial weaving technology on a 12-spindle braiding machine When weaving the thin wire structure at both ends, the liner tube is not used; when weaving the middle part, a polytetrafluoroethylene liner tube with a diameter of 1.4 mm is used to obtain a prefabricated suture line with a three-section variable-section structure.

[0047] Step 2: heat-treat the prefabricated suture thread obtained in step 1 in an oven at 80°C for 10 minutes to obtain a structurally stable suture thread with a diameter of 0.3mm at both ends and...

Embodiment 2

[0058] A variable cross-section porous ribbon suture for promoting tendon healing, comprising such as figure 1 The specific steps for the preparation of the three-section variable-section suture and the hydrogel coating shown are as follows:

[0059] Step 1: Select 55.0dtex ultra-high molecular weight polyethylene multifilament as the braiding yarn 4, 110.0dtex polycaprolactone multifilament as the shaft yarn 5, and then prepare sutures by two-dimensional three-axial weaving technology on a 12-spindle braiding machine When weaving the thin wire structure at both ends, the liner tube is not used; when weaving the middle part, a polytetrafluoroethylene liner tube with a diameter of 1.4 mm is used to obtain a prefabricated suture line with a three-section variable-section structure.

[0060] Step 2: heat-treat the prefabricated suture thread obtained in step 1 in an oven at 80°C for 10 minutes to obtain a structurally stable suture thread with a diameter of 0.3mm at both ends and...

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Abstract

The invention relates to a variable cross-section porous strip-shaped suture line for promoting tendon healing and a preparation method thereof, and belongs to the technical field of biomedical repairmaterials. The suture line comprises a suture line body and a hydrogel coating, and the suture line body is arranged to be of a three-section variable cross-section structure. Two ends of the sutureline body are arranged to be in a fine line shape which is easily connected with a suture needle so as to easily penetrate through tissues, and the middle portion is arranged to be in a porous band shape facilitating tissue ingrowth and reducing tendon cutting. The hydrogel coating which serves as tissue glue and has antibacterial, anti-inflammatory and healing-promoting effects is arranged on theouter surface of the suture line. The prepared suture line is good in operability and small in tissue cutting, is beneficial for promoting tendon healing, and has good application prospects.

Description

technical field [0001] The invention relates to a variable cross-section porous strip-shaped suture for promoting tendon healing and a preparation method thereof, belonging to the technical field of biomedical repair materials. Background technique [0002] Tendon injuries are very common in daily life. Excessive exercise, traffic accidents, aging, etc. may cause tendon injuries. Due to the poor self-healing ability of tendon, surgical repair is required after injury, and suture is an indispensable material for tendon repair, and its structure and performance have a great influence on the effect of tendon repair. Existing commercial sutures such as Ethibond, Ultrabraid, OrthoCord, etc. have been proven to have good mechanical support for tendon repair, but there are still the following problems: (1) These sutures have a circular structure, and the stress concentration at the suture point is obvious , it is easy to cut the tendon, and it is easy to cause secondary damage to ...

Claims

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Application Information

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IPC IPC(8): A61L17/00A61L17/14A61B17/06
CPCA61B17/06166A61B2017/00526A61L17/00A61L17/005A61L17/145A61L2300/21A61L2300/404A61L2300/41
Inventor 王璐张倩毛吉富林婧李超婧王富军吕璐瑶
Owner DONGHUA UNIV
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