Dressing material containing medicine chitoholosida and its preparation method

A polyvinyl alcohol and chitosan technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of lack of antibacterial ability, functional improvement, wound infection, etc., to reduce wound bacterial infection and reduce the burden of dressing change , the effect of reducing the risk

Inactive Publication Date: 2005-02-16
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of hydrogel film has moisture permeability and air permeability, but like CN 1225370, there is no pharmaceutical composition that can inhibit or kill bacteria in the gel, does not have active antibacterial ability, and is easy to cause wound infection
[0006] CN 2383500 provides a hydrogel composite wound dressing. This utility model patent only provides convenience for the use of the hydrogel film disclosed in CN 1121876, and does not improve the function

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1). Take 90.0 g of double distilled water and 20.0 g of polyvinyl alcohol to make solution A, wherein the degree of polymerization of polyvinyl alcohol is 1500, and the degree of alcoholysis is 98%;

[0062] 2). Take 50.0g of twice distilled water and 8.0g of polyvinylpyrrolidone to completely dissolve the polyvinylpyrrolidone into a homogeneous solution B. The weight average molecular weight of polyvinylpyrrolidone is 8.0×10 5 gmol -1 ;

[0063] 3). After mixing solution A and solution B, add 4.0 g of carrageenan, 10.0 g of glycerin, 10.0 g of polyethylene glycol 400, chitosan, double-distilled water and acetic acid mixed solution, and stir at constant temperature for 2 hours to obtain solution 3. The molecular weight of polysaccharide is 1.0×10 6 gmol -1 , DD=80.0%, the concentration of acetic acid is 3.5%, and the solid polymer content in solution 3 is 18%;

[0064] 4). Put the solution 3 at room temperature for 8 hours, then pour the solution into a polyethylene...

Embodiment 2

[0068] 1). Take 90.0g of normal saline and 20.0g of polyvinyl alcohol to make solution A, wherein the degree of polymerization of polyvinyl alcohol is 3000, and the degree of alcoholysis is 98%;

[0069] 2). Take 50.0g of normal saline and 10.0g of polyvinylpyrrolidone to make solution B, wherein the weight average molecular weight of polyvinylpyrrolidone is 1.3×10 6 gmol -1 ;

[0070] 3). After solution A and solution B are mixed, add 40.0g glycerin, chitosan, normal saline, acetic acid mixed solution to obtain solution 3, wherein chitosan 10.0g, chitosan molecular weight 5.0×10 5 gmol -1 , DD=98.0%, glycerol 20.0g, solution 3 solid polymer content 20%;

[0071] 4). The lamination process is the same as in Example 1, the lamination thickness is up to 5mm, and the freezing-melting cycle is processed once by a circulating freezer. 60 Coγ-ray cross-linking at room temperature, dose 80kGy;

[0072] 5). The treatment process is the same as in Example 1, but the gel with a dry...

Embodiment 3

[0075] 1). Weigh 20.0 g of polyvinyl alcohol and dissolve it in 90.0 g of double-distilled water to make solution A, wherein the degree of polymerization of polyvinyl alcohol is 2500, and the degree of alcoholysis is 100%;

[0076] 2). Dissolve 10.0 g of polyethylene oxide in 50.0 g of double distilled water to make solution B, wherein polyethylene oxide Mη=6.3×10 5 gmol -1 ;

[0077] 3). After mixing solution A and solution B, add 4.0 g of carrageenan, 40.0 g of glycerin, polyethylene glycol 200, and secondary water, and stir for 2 hours to obtain solution 3, which contains 4.0 g of glycerin, polyethylene glycol 100 10.0g, the solid polymer content in solution 3 is 17%;

[0078] 4). The lamination process is the same as in Example 1, the lamination thickness is up to 3 mm, and the circulation freezer freeze-melt cycle is processed 3 times, 60 Co gamma-ray irradiation cross-linking, the dose is 30kGy;

[0079] 5). The treatment process is the same as in Example 1, but the ...

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Abstract

The invention produces polyethylene alcohol hydrogel dressing containing medicine and chitosan with 60Co gamma-radial or high energy electron beam radial cross linking. Additional, adds in some humectant, plasticizer, medicine, the solvent is the secondary distilled water, physiological saline or phosphate neutral buffer liquid. The product can release medicine slowly and has natural amylose chitosan with biology sterilization activity, it has active sterilization function, at the same time, it has high water quantity, and good water reserving performance, the mechanical intensity is moderate, and the light penetration and air penetration are excellent. It can accord the demands for curing each kind of wound. It can used as the permanent dressing for light skin injuries, and it also can be applied to the temporally close of severe skin organization wound or burn wound.

Description

technical field [0001] The invention relates to a polyvinyl alcohol hydrogel dressing containing medicine and chitosan and a preparation method thereof. Background technique [0002] In the past, dry treatment methods were used for wounds such as knife wounds and burns, but wet treatment was proposed in the early 1960s. Moisturizing the wound can reduce pain and speed up wound healing. In treating burns, for example, wounds heal faster if blisters don't rupture, suggesting that maintaining fluid seepage from wounds is also a factor in promoting wound healing. Traditional medicine treats various skin injuries such as dry burns, wounds, scalds and bedsores. In order to protect the wound surface, reduce infection and accelerate wound healing, sterile gauze or gauze soaked in antibacterial solution is generally used to treat the wound. However, gauze is easy to adhere to the wound , form scabs, new epithelial and granulation tissue are often destroyed when changing dressings, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44
Inventor 景遐斌于海军陈学思杨立新徐效义张培标
Owner CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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