471 results about "Citric Acid Monohydrate" patented technology

The invention provides a new liquid aqueous drug preparation of an anti-TNF (tumor necrosis factor)-alpha human monoclonal antibody for strengthening the stability, wherein antibody solution is stabilized and osmotic pressure is regulated by sorbitol; disodium hydrogen phosphate / citric acid monohydrate or sodium acetate / acetic acid is taken as a buffer agent, and preferably, the disodium hydrogen phosphate / citric acid monohydrate is taken as the buffer agent; and tween-20 is taken as a surfactant, so that antibody preparation is stable, and long in retention time, meanwhile, preparation components are simplified, and the preparation is prepared simply and conveniently.

Discussed herein are pharmaceutical compositions containing Ibrutinib and processes for preparing them. The compositions may be utilized in the treatment of a variety of conditions including, without limitation, B-cell proliferative disorders such as non-Hodgkin lymphoma (diffuse large B cell lymphoma, follicular lymphoma, mantle cell lymphoma or burkitt lymphoma), Waldenstrom macroglobulinemia, plasma cell myeloma, chronic lymphocytic leukemia, lymphoma, or leukemia. These compositions are designed for oral ingestion. The compositions are contained within a capsule such as a standard or sprinkle or in a liquid formulation such as a suspension. In one embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, croscarmellose sodium, sodium lauryl sulfate, and magnesium stearate. In another embodiment, the pharmaceutical composition contains Ibrutinib, a salt, prodrug, or metabolite thereof, microcrystalline cellulose, carboxymethylcellulose sodium, hydroxypropylmethylcellulose, citric acid monohydrate, disodium hydrogen phosphate, sucralose, sodium methyl parahydroxybenzoate, sodium ethyl parahydroxybenzoate, concentrated hydrochloric acid, sodium hydroxide, and water.

The invention provides a fabric detergent with colour-preserving function and preparation method thereof. The detergent contains sodium fatty alcohol ether sulphate, laurylamide propyl betaine, alkyl glucoside, fatty alcohol polyoxyethylene (9) ether, sodium alpha-olefin sulphonate, 3-methooxyl-3-methyl-1-butyl alcohol, 1-vinyl pyrrolidone, 1-vinyl copolymer, sodium chloride, 1, 2-benzisothiazolin-3-one, essence, citric acid monohydrate and deionized water. The invention obtain favourable detergency in clothing washing process while realizing colour-preserving effect; the detergent is environmentally friendly, cleaning and colour-preserving are completed in one step, the detergent is non-toxic and non-irritant, and resource is saved.

The various embodiments herein provide a hyper branched polyester and a method of synthesizing the same. The embodiments herein also provide a method of encapsulating a drug into the void spaces of the polymer to act as a drug delivery system. The hyper branched polyester mer comprises an acidic moiety and an alcoholic moiety. The acidic moiety is citric acid monohydrate. The alcoholic moiety is glycerol. The acidic moiety and the alcoholic moiety are randomly arranged in the hyperbranched polymer. The method comprises of heating the mixture of citric acid and glycerol at temperatures of 90 to 150° C. by constant stirring for different time periods. In the method of encapsulation, the drug solution is drop-wise added to polymer solution at 37° C. by constant stirring for 24 h.

The invention provides a type of marine organism shell powder paint, mainly comprising biosynthesis adhesive, sodium hexametaphosphate, shell powder, emulsifier, and citric acid mono. The marine organism shell powder paint is purely natural, environment-friendly, of simple preparation and of low manufacturing cost, and has no toxic effects on human body.

The invention relates to the field of functional materials, particularly a preparation method of an adsorbent for acid dye wastewater treatment. The invention mainly solves the technical problem that dyeing wastewater can not be easily decolorized, can not achieve the discharge standard and the like in the prior art. The preparation method comprises the following steps: putting 8-10g of beta-cyclodextrin into 1-2g of citric acid monohydrate, and adding 1g of PEG-400 and 0.25g of sodium dihydrogen phosphate to obtain a beta-cyclodextrin polymer by polymerization; adding a silane coupling agent into a chitosan solution; and cross-linking the beta-cyclodextrin polymer with the chitosan to obtain a beta-cyclodextrin-chitosan porous membrane, wherein the mol ratio of the chitosan to the beta-cyclodextrin polymer is 1:3..

The invention relates to a rose extract liquid beverage which is made from the following raw materials in percentage by weight: 88.7% to 92.8% of first-grade reverse osmosis water and 7.2% to 12.7% of a rose flower mixed liquid. The rose flower mixed liquid contains the following components in percentage by weight: 36.3% to 58.1% of rose flower stock solution, 20.8% to 70.1% of oligosaccharides, 3.6% to 5.0% of citric acid monohydrate, and 7% to 10.0% of natural fruit juice. The invention also provides a preparation method of the rose extract liquid beverage. The invention has the advantages that: the formula is scientific; the rose extract solution, rose essential oil reduction liquid and rose cell solution in the rose flower stock solution which serves as the major material are obtained by different processes; the rose extract liquid beverage contains more than 54 kinds of rose active molecules, has fresh and slight fragrance and can effectively relieve mental stress, remove toxins in vivo and keep body healthy; the oligosaccharides and the natural fruit juice serve as sweetener additive and flavor additive respectively; and the rose extract liquid beverage is free of any pigment or synthetic chemical and conforms to the needs for backing to the nature.

The invention provides a disinfecting detergent and a preparation method thereof. The disinfecting detergent contains didecyldimethylammonium chloride, didecyldimethylammonium bromide, poly(hexamethylene biguanide) hydrochloride, dodecyldimethylbenzylammonium chloride, fatty alcohol-polyoxyethylene ether (9), fatty alcohol polyoxyethylen ether (7), fatty alcohol polyoxyethylen ether (8), alkyl polyglucoside, alkanolamides of fatty acids, lauramidopropyl betaine, essence, citric acid monohydrate food grade and deionized water. The method has the advantages of environmentally-friendliness, combination of disinfection and cleaning, synchronous completion of stain removal and disinfection, safety, unstimulating property, and resource conservation.

A point-of-care, screening kit for use by a heath care worker to create custom test strips for screening the bodily fluids of an individual for various, medical conditions includes: (a) a plurality of reagents (12), (b) a substrate (18) configured to: i) receive one of the reagents and react with it so as to cause it to acquire a first characteristic color, and, ii) upon the addition of the individual's bodily fluid to the substrate, acquire, as a result of the formulation of each of the reagents, a second, dichotomous characteristic color when the individual has a specific one of the various, medical conditions. This kit also includes: (c) a plurality of containers (10) having indicia (26) that are reflective of the reagent within the container and which of the various medical conditions is being screened for with the use of the container and the characteristic first and second colors which are indicative of the individual having a screened for medical condition, and (d) one of the reagents being a protein reagent that includes appropriate quantities of: water, isopropyl alcohol, citric acid monohydrate, sodium citrate iribasic monohydrate, tetrabromophenol blue and tartrazine.

The invention discloses a method for preparing luminescent adjustable nitrogen-doped carbon quantum dots by one-step process. The method comprises the following steps: adding octadecylamine into octadecene, and heating and stirring until octadecylamine is completely dissolved to obtain a solution A; heating the solution A, quickly adding citric acid monohydrate for reaction to obtain a deep red brown reaction solution B; uniformly mixing the reaction solution B with methanol, cooling to the room temperature, centrifuging, and washing to obtain the purified nitrogen-doped carbon quantum dots. The method has the advantages that the method is simple in process and convenient to perform; the prepared nitrogen-doped carbon quantum dots are luminescent, adjustable and regularly changed in grain size, have the characteristics of no toxicity, simple functionalization, high and stable fluorescence intensity, controllable fine size and the like, are applied to bioimaging, sensing and probe technologies and photoelectric devices such as solar cells, luminescent devices and field effect transistors, can be dissolved in an organic solvent such as methylbenzene, and are of important significance on development of novel organic nanomaterials and application to the photoelectric devices.

The invention belongs to the technical field of rice planting fertilizers, in particular to a rice selenium-enriching and cadmium-reducing foliar fertilizer. The foliar fertilizer comprises citric acid monohydrate, small fruit saponin, sodium selenite, urea, potassium chloride, potassium dihydrogen phosphate, soluble trace element compounds, soybean peptides and tartrate. The foliar fertilizer greatly improves the absorption and transformation rate of rice for selenium, and further has a good cadmium inhibiting property, and is rich in nutrients, easily absorbed by the rice, high in selenium enriching and cadmium reducing efficiency and stable in effect after being sprayed to the rice, so that the rice is high in yield.

The invention provides an electrospinning preparation method of BiVO4 (bismuth vanadium oxide) fibers. The electrospinning preparation method of the BiVO4 fibers comprises the following steps: firstly, dissolving Bi (NO3)3.5H2O and citric acid monohydrate into deionized water, stirring uniformly, adding ethanolamine, and stirring till a clear state to obtain a solution A; secondly, dissolving ammonium metavanadate and the citric acid monohydrate into deionized water to obtain orange mixed liquid, and stirring the mixed liquid at a constant temperature of 70DEG C till the color of the mixed liquid turns from orange to dark blue and no sediment is generated so as to obtain a solution B; thirdly, mixing the solution A and the solution B to obtain a BiVO4 precursor solution; fourthly, uniformly mixing the BiVO4 precursor solution and an ethanol solution of polyvinylpyrrolidone to obtain an electrospinning solution; fifthly, filling the electrospinning solution into an injector with an injection needle of 0.5 microns, and spinning to obtain composite fibers on a receiving device; and finally, drying the composite fibers at room temperature, and heating to remove residual polyvinylpyrrolidone so as to obtain the BiVO4 fibers. The electrospinning preparation method is simple in process, convenient to operate and environment-friendly; and the prepared BiVO4 fibers have relatively good photocatalysis in ultraviolet light.

The invention discloses a waterproof and fireproof inorganic blocking material which is prepared by mixing the following raw materials with the parts by weight: 40-56 parts of construction gypsum, 0-20 parts of grade I fly ash or grade II fly ash, 24-40 parts of fine mineral powder and common Portland cement, 0-1 part of methyl cellulose ether, 0-3 parts of calcium stearate or zinc stearate or the mixture thereof, 0-0.1 part of citric acid monohydrate, 0-300 parts of quartz sand, 0-75 parts of vitrified micro bead and 0-75 parts of expanded vermiculite. The waterproof and fireproof inorganic blocking material of the invention has the advantages of superior waterproof and fireproof performance, fast coagulating and hardening speed, quick increase in early strength, moderate later strength, convenient disassembly, simple construction, immediate use after being mixed, free adjustment of coagulating time, convenient storage and transportation, environmental protection, etc.

The invention discloses a Pd@PtNi nano-crystal with an octahedral core-shell structure, and a preparation method thereof for the first time. The preparation method of the crystal comprises the following steps: adding an octahedral Pd nanocrystal and hydrazine hydrate to an aqueous solution of PVP and citric acid monohydrate, injecting the obtained solution to a K2PtCl4 and NiCl2.6H2O mixed aqueous solution, heating, and stirring to obtain the Pd@PtNi nano-crystal with an octahedral core-shell structure. The invention also discloses a Pd@PtNi / C metal nano-catalyst, and a preparation method and a use thereof. The preparation method of the Pd@PtNi / C metal nano-catalyst comprises the following steps: injecting carbon black into the Pd@PtNi nanocrystal, carrying out ultrasonic treatment, washing, and drying to obtain the nano-catalyst. The nano-catalyst can be used in the fuel cell cathode oxygen reduction reaction process. The preparation method of the Pd@PtNi nanocrystal has mild and fast reaction, and the obtained Pd@PtNi nanocrystal has the advantages of uniform dimension, good dispersibility, enhancement of the utilization rate of Pt atoms, and enhancement of the catalytic activity on the fuel cell cathode oxygen reduction reaction.

The invention provides a new liquid aqueous drug preparation of an anti-TNF (tumor necrosis factor)-alpha human monoclonal antibody for strengthening the stability, wherein antibody solution is stabilized and osmotic pressure is regulated by sorbitol; disodium hydrogen phosphate / citric acid monohydrate or sodium acetate / acetic acid is taken as a buffer agent, and preferably, the disodium hydrogen phosphate / citric acid monohydrate is taken as the buffer agent; and tween-20 is taken as a surfactant, so that antibody preparation is stable, and long in retention time, meanwhile, preparation components are simplified, and the preparation is prepared simply and conveniently.

The invention relates to a compound fruit juice drink of common macrocarpium fruit, mulberry fruit, fragrant solomonseal rhizome and barbary wolfberry fruit, a compound juice concentrate of common macrocarpium fruit, mulberry fruit, fragrant solomonseal rhizome and barbary wolfberry fruit is obtained after mixing 13-15g of common macrocarpium fruit juice concentrate, 7-9g of mulberry fruit juice concentrate, 140-160g of fragrant solomonseal rhizome and 40-60g of barbary wolfberry fruit extract liquid according to parts by weight and preparing, then the compound juice concentrate of common macrocarpium fruit, mulberry fruit, fragrant solomonseal rhizome and barbary wolfberry fruit is evenly mixed with chromium trichloride water solution, xylitol syrup and auxiliary materials of citric acidmonohydrate, aspartame, potassium sorbate, ethyl maltol, fatmelon tea phenol and water, after that, a cover is added for sealing, degassing, filtration, filling and sterilization are sequentially carried out for obtaining the compound fruit juice drink of common macrocarpium fruit, mulberry fruit, fragrant solomonseal rhizome and barbary wolfberry fruit. The compound fruit juice drink transfers ingredients in common macrocarpium fruit, mulberry fruit, fragrant solomonseal rhizome and barbary wolfberry fruit which are active to human body into the drink, and has the outstanding health care function and the significant cosmetic effect.

The invention relates to a citric acid continuous cooling crystallization system and a method thereof. In an existing method of producing citric acid monohydrate crystal, intermittent processing equipment is used, product size distribution is uneven, a crystal product is agglutinated seriously, and difference between product batches is large. According to the crystallization method, a citric acid solution is heated and concentrated through two-effect heat exchange, then is input into a circulating pipeline composed of an indirect cooler and a cooling crystallizer through a feed pump and is continuously cooled for cooling crystallization in the circulating pipeline under the action of a circulating pump, and citric acid monohydrate slurry is obtained through cooling crystallization; the citric acid monohydrate slurry is discharged through a discharging pump, conveyed to a crystal slurry buffering tank to be buffered and then input into a centrifugal separation device for solid-liquid separation. According to the continuous cooling crystallization method, intermittent crystallization operation of using a crystallization kettle for feeding and discharging and conducting cooling in the kettle in the past is replaced, the feeding, discharging and cooling flow path is stabilized, continuity and stability of product quality can be effectively ensured, and production efficiency and product quality of citric acid monohydrate are greatly improved.

The invention provides a preparation method of a gel ball. The preparation method of the gel ball comprises the following steps: a, mixing sodium alginate, konjac glucomannan and sugar with water to obtain a mixed solution; b, mixing the mixed solution with citric acid monohydrate, potassium sorbate and pigment to obtain a co-mixed sol; and c, adding the co-mixed sol to a calcium lactate solution and carrying out cross-linking to obtain the gel ball. The pH value of the gel ball prepared by the preparation method is 3.9-4.4, the Brix value is 4.5%-7.5% and the particle diameter is 3.0mm-6.0mm. The gel ball is stable under the acid conditions and has small possibilities of deforming out of water, changing color and taste and growing microorganism; the gel ball can be added to jelly or other foods for use. Experimental results show that the composite gel ball prepared by the method can be placed in a heat preservation box at a temperature of 37 DEG C without change in color, taste, hardness and the like in nine weeks; microbiological detection is also qualified.

The invention discloses a method for preparing tributyl citrate by using modified cation exchange resin as a catalyst, which comprises the following main steps of: carrying out esterification reaction on citric acid monohydrate, n-butyl alcohol and the catalyst at 140-160 DEG C, wherein the catalyst is macroporous strong acid cation exchange resin modified by anhydrous stannic chloride; after reaction is finished, separating to remove the catalyst in an esterification reaction product; and carrying out alkali washing, water washing and distillation purification on separated liquid to obtain tributyl citrate. The separated catalyst can be recycled and basically keeps the activity unchanged. According to the method for preparing the tributyl citrate,, disclosed by the invention, the modified macroporous strong acid cation exchange resin is used as the catalyst, and the reactant n-butyl alcohol is used as a water entrainer, therefore the use of toxic benzene, toluene, and the like is avoided, and no pollution is brought in the preparation process; and the method disclosed by the invention has the advantages of mild reaction conditions, short reaction time, low production cost and citric acid reaction conversion rate capable of reaching more than 98 percent.

The invention discloses iron-nitrogen co-doped mesoporous carbon and a preparation method and application thereof. The preparation method comprises taking citric acid monohydrate and magnesium nitrate hexahydrate, adding the citric acid monohydrate and magnesium nitrate hexahydrate into deionized water, stirring the solution for dissolution, then placing the solution in an oven, carrying out baking for a period of time to obtain foamy solids as precursors, mixing the precursors, a nitrogen source and an iron salt, firing the mixture in an atmosphere furnace in a nitrogen protective atmosphere, and cooling the product to the room temperature to obtain the iron-nitrogen co-doped mesoporous carbon NMC-Fe. The NMC-Fe has a flower-like structure, petals of the flower-like structure are multi-layer carbon sheets and the iron compound is distributed in the carbon sheets. The iron-nitrogen co-doped mesoporous carbon has high stability and can be used for preparation of aromatic azo compounds. The chemical selectivity of the catalytic reaction is very good so that the yield of the product azobenzene is 94%. Compared with the existing common preparation method, the preparation method provided by the invention has a higher yield.

The invention relates to a washing agent with stain removal and softening functions and a preparation method thereof. The washing agent takes sodium fatty alcohol polyoxyethylene ether carboxylate, 1-methyl-2-butter-3-ethyl amide-imidazoline ammonium sulfate methyl ester, dihydro butter acid methyl ester dimethyl ammonium, alkyl polyglucoside, laurylamidopropyl betaine, cocoamidopropyl ammonium oxide, fatty alcohol-polyoxyethylene (9) ether, fatty alcohol-polyoxyethylene (7) ether, fatty alcohol-polyoxyethylene (5)ether, essence, 1,2-benzisothiazolinone-3-ketone, citric acid monohydrate and de-ionized water as raw materials; the softening function of cations on fabrics and the high stain removal, emulsification and degreasing performances of non-ions are utilized and are rationally combined so as to form a stable ion system; and the washing agent simultaneously has high stain removal capacity and good softening function, is applied to the washing of underwear, the clothing of infants, silk, sweaters, bed sheets and quilt covers, makes washing and softening finished at one time, has no toxicity and irritation and saves use cost.

The invention discloses a plant antioxidant functional feed additive, which is prepared from the following raw materials in parts by weight: 0 to 10 parts of 2,6-di-tert-butyl-p-cresol, 1 to 10 parts of ethoxyquin, 1 to 5 parts of methionine hydroxy analog, 1 to 5 parts of talc powder, 1 to 10 parts of citric acid monohydrate, 1 to 80 parts of ampelopsis, and 5 to 20 parts of medical stones. The additive has the advantages that: the traditional natural plant ampelopsis is applied to livestock production, the ampelopsis containing natural plant anti-oxidation mould inhibitor dihydromyricetin has good effects of removing free radicals and resisting lipid peroxidation, and the problem of oxidizing grease in the feed rich in Cu<2+>, Fe<2+> and other metal ions can be solved; and therefore, the additive is a high-efficiency green functional anti-mould anti-oxidation additive product. The additive can be used as an excellent substitute product for chemically synthesized anti-mould anti-oxidation products, so that a new opportunity is brought to the development of feed industry, and establishment of a healthy culture production mode is facilitated.

A collagen protein milk drink comprises (weight in each ton): fresh milk 200-400Kg, white sugar 40-60Kg, protein sugar 0.8-1.2Kg, stabilizer 4-6Kg, citric acid monohydrate 2-4Kg, lactic acid 1-2Kg, sodium citrate 0.1-0.5 Kg , collagen protein 0.5-1.5Kg, milk-type flavor 0.1-0.4Kg, corn flavor 1-2Kg and water.

The invention discloses an industrial production method of citric acid tofacitinib. The method comprises the following steps: (1) adding a compound SMA and a compound SMB to a mixed solvent 1 which comprises DMSO and purified water, and catalyzing through DIPEA to react to obtain an intermediate INA; (2) carrying out a homogeneous reaction of the INA under an alkaline condition to obtain a rough intermediate INB; (3) refining the rough INB through low-level alcohol and water to obtain fine INB; (4) treating the fine INB by debenzylation and acidification to obtain an intermediate INC (salt form); (5) carrying out a reaction between the INC and SMC to obtain an intermediate IND which is tofacitinib free alkali; (6) preparing salt through the IND and citric acid monohydrate in purified waterto obtain citric acid tofacitinib. According to the method, the defects of preparation technologies in existing literatures can be solved; the used solvents are three types of solvents, so that the environmental pollution is low; the time consumption is small; the operation processes are simple; industrial production can be carried out. The formula is shown in the description.

The invention discloses a preparation method for nano MnO of a negative electrode material of a lithium ion battery, which belongs to the technical field of lithium ion battery material and electrochemistry. The method comprises the following steps of: firstly dissolving polyvinylpyrrolidone K30 in glycol under the condition of magnetic stirring, wherein the concentration of the polyvinylpyrrolidone K30 is 2.0 to 4.0 g / L; then adding citric acid monohydrate with the concentration of 8.4 to 42.0 g / L; adding manganese acetate tetrahydrate when the adding citric acid monohydrate is dissolved completely, wherein the molar ratio of the citric acid monohydrate to the manganese acetate tetrahydrate is between 0.3 and 1.6; and then subjecting the mixture to magnetic stirring, heating the mixture between 140 DEG C and 180 DEG C to evaporate the solvent; transferring the red-brown sticky material obtained into an over of 140 to 180 DEG C to dry for 3 to 5 hours; and finally subjecting the product dried to thermal treatment of 600 to 1000 DEG C for 1 hour in H2 / Ar mixed atmosphere to obtain nano MnO of a negative electrode material of a lithium ion battery. The preparation method for nano MnO of a negative electrode material of a lithium ion battery provided by the invention has the advantages that the specific capacity of the nano MnO negative electrode material prepared by means of themethod provided by the invention is high, the cycle performance is stable, the security performance is good, the preparation method is simple and easy, the production conditions are mild, and the preparation method is suitable for large-scale production.

The present invention relates to a diesel engine exhaust SCR denitration catalyst and a preparation method thereof, a cerium molybdenum complex oxide is used as a catalytically active component, praseodymium, tungsten or lanthanum is used as a cocatalyst blend, and alumina is used as a carrier. The cerium molybdenum complex oxide, a co-catalysis ion precursor complex solution, pseudo-boehmite, pure gamma alumina, citric acid monohydrate and other organic additives are uniformly stirred, mixed, decayed, extruded and molded, then dried in the shade, dried, and roasted to obtain an integrated catalyst. The catalyst is environment-friendly, high in NOx removal efficiency, and wide in range of active temperature, NOx removal efficiency at 250 DEG C-425 DEG C is more than 95%, the highest denitration activity is up to 100%; and the diesel engine exhaust SCR denitration catalyst has excellent sulfur resistance, water poisoning resistance, high mechanical strength, good ammonia storage performance, high CO and HC catalytic oxidation activity and low catalyst cost, and is cost-effective, and especially suitable for diesel engine exhaust NOx removal.

The invention relates to the field of lithium ion batteries, and discloses a silicon negative electrode material and a negative electrode sheet coated with carbon nanotubes, a preparation method thereof and a lithium ion battery. The preparation method of the silicon negative electrode material comprises the following steps: (1) dissolving polyethylene glycol, citric acid and / or citric acid monohydrate and transition metal salt in a solvent to obtain a precursor solution; (2) mixing the precursor solution with the silicon material, filtering, washing, and then drying under the condition of isolating air to obtain the precursor-coated silicon material; (3) heating the precursor-coated silicon material in an air atmosphere to 200-280 DEG C for sintering for 1.5-3.5 hour, naturally cooling toobtain MOx / Si composite pow; (4) heating the MOx / Si composite powder under the protection of inert gas and / or weak reducing gas to 400-800 DEG C for sintering for 1-5h. The silicon negative electrodematerial obtained by the method has stable electrochemical performance, can avoid damage to the structure of carbon nanotubes, has simple process, does not use flammable and explosive alkane as carbon source, and has high safety.

The invention discloses a displacement type electroless gold plating solution, which comprises monopotassium citrate monohydrate bis(malononitrile alloy (I)), a conductive compound, a buffering agent, a shielding complexing agent, a nickel oxidation remover and water. The nickel oxidation remover is one or more of diethylenetriamine, pentamethyldiethylenetriamine, triethylenetetramine, hexamethyltriethylenetetramine and tetraethylenepentamine. The present invention provides the source of gold ions with potassium citrate monohydrate (malononitrile alloy (I)) as the displacement type chemical gold plating solution, thus does not need to use potassium gold cyanide as the gold source compound, and is an environmentally friendly displacement chemical Gold plating solution. Since the substrate metal is easily corroded in the electroless plating solution of the displacement type to produce more nickel oxides, the nickel oxide remover is used to remove the nickel oxides on the surface of the substrate metal. Experimental results show that the uniformity of the plating film formed by using the displacement type chemical gold plating solution provided by the invention is good, the grain boundary has no corrosion condition, and the solder wettability is good.