The invention relates to the field of compound fertilizers and particularly relates to a selenium-enriched efficient sustained release compound fertilizer which is prepared from the following raw materials in parts by weight: 10-15 parts of 1250-2000-mesh diatomite, 20-25 parts of urea, 10-12 parts of ammonium dihydrogen phosphate, 2-4 parts of zinc sulfate, 6-8 parts of tertiary calcium phosphate, 10-12 parts of potassium chloride, 18-22 parts of dried pig manure, 15-17 parts of soybean meals, 10-12 parts of soybean straw powder, 10-12 parts of detoxified tung seed cake, 4-6 parts of Japanese banana leaf pulp, 3-5 parts of water hyacinth powder, 10-12 parts of hydroxymethyl cellulose, 4-5 parts of polyacrylamide, 0.1-0.2 part of ammonium bicarbonate, 0.2-0.3 part of camphor, 2-4 parts of selenium-enriched yeast, 1-2 parts of alkyldimethyl benzylammonium chloride, 2-3 parts of nanocarbon, 2-4 parts of zinc gluconate, 6-8 parts of table vinegar and 4-5 parts of additive. The compound fertilizer is prepared from easily available raw materials and is rich in nutrients; the nutrients which are doubly coated by using diatomite and a coating agent cannot be easily lost, thus the fertilizer effect lasts very long time; and the raw materials contain abundant selenium element after being fermented by the selenium-riched yeast, thus the selenium-enriched efficient sustained release compound fertilizer is capable of increasing the content of the selenium in crop fruits, increasing the economic value of vegetables and fruits, and remarkably improving the benefit.