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Liquiritin preparation and application thereof

A glycoside preparation and liquiritin technology, applied in the liquiritin preparation and application field, can solve problems such as diseases or symptoms that have not yet been seen, and achieve the effects of promoting the excretion of phenol red in the airway of mice, strong expectorant effect, and small toxic and side effects

Inactive Publication Date: 2012-03-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports of it being prepared into medicine and treating any disease or symptom

Method used

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  • Liquiritin preparation and application thereof
  • Liquiritin preparation and application thereof
  • Liquiritin preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 1. Composition and preparation process of glycyrrhizin capsule preparation

[0016] 1. Composition: 1000 capsules

[0017] Glycyrrhizin 40g

[0018] Sodium hydroxide 3.2g

[0019] Povidone 15g

[0020] Meglumine 10g

[0021] Microcrystalline cellulose 115g

[0022] 20g lactose

[0023] Total 203.2g

[0024] 2. Formulation basis and screening process

[0025] 2.1 Basis of formulation composition

[0026] According to the pharmacodynamics test, the glycyrrhizin capsules are formulated, the specification: the glycyrrhizin content is 40mg / capsule.

[0027] The role of excipients in the prescription: sodium hydroxide: solubilizer; povidone: binder; meglumine: solubilizer; microcrystalline cellulose: diluent, disintegrant; lactose: diluent.

[0028] Dissolve glycyrrhizin with sodium hydroxide ethanol solution. Preliminary tests show that when glycyrrhizin is completely salted (glycyrrhizin: sodium hydroxide = 40: 3.1), it is not completely dissolved. A slight excess of sodium hydroxide is glyc...

Embodiment 2

[0062] Example 2 Pharmacodynamic study

[0063] With reference to the "Compilation of Guidelines for Preclinical Research of New Drugs (Western Medicine) (Pharmaceutical Pharmacology and Toxicology)" by the State Food and Drug Administration, this experimental program was designed. Two experimental animal models for antitussives, two experimental animal models for expectorants, and three antiasthmatic test methods were selected to study the antiasthmatic, antitussive and expectorant aspects of glycyrrhizin capsules or tablets. The test materials, methods and results are as follows:

[0064] 1. Material:

[0065] Medicines and reagents

[0066] 1) Citric acid: Shanghai No. 1 Chemical Reagent Factory, batch number 20070201, prepared with distilled water to a concentration of 15% for use;

[0067] 2) Codeine Phosphate Tablets: Qinghai Pharmaceutical Factory, batch number 20060615; distilled water to prepare a 0.5mg / ml suspension;

[0068] 3) Capsaicin (capsaicin): Sigma Chemical Company, ...

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PUM

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Abstract

The invention provides a liquiritin preparation with the molecular formula of C26H30O13 and the molecular weight of 550. The liquiritin is singly prepared or by matching with other active components or auxiliary materials, and the preparation composition is counted in such a way that 1000 particles contain 40g of liquiritin. The liquiritin preparation has stronger effect for relieving cough and eliminating phlegm, therefore, the preparation can be singly prepared by liquiritin or by the liquiritin matching with other active components or auxiliary materials, can be used for improving symptoms of cough and profuse sputum, and can be applied to the preparation of medicine for curing acute cough, chronic cough and profuse sputum. The liquiritin preparation originates from natural plants, can be made into a health-care product, and provides the natural cough-relieving medicine with less toxic side effect and obvious healing effect for clinical treatment.

Description

Technical field [0001] The present invention belongs to medicinal use, relates to glycyrrhizin medicinal preparations and uses, and specifically relates to the application of glycyrrhizin in preparing medicines for treating cough and phlegm. Background technique [0002] With the development of the global economy, the sources of industrial and civil pollution continue to increase, coupled with inadequate environmental governance and other factors, the incidence of respiratory diseases has shown a clear upward trend, and the mortality rate caused by them has also increased year by year. At present, respiratory diseases have become the major humans. One of the "killers". However, this has also created a broader market space for companies that produce drugs for respiratory diseases. As an important part of respiratory system drugs, the market for expectorant and antitussive drugs is also increasing year by year. Cough and phlegm are mostly the main symptoms of respiratory diseases...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P11/14A61P11/10
Inventor 谢强敏吴希美谢诒诚董新威曹睿
Owner ZHEJIANG UNIV
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