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Preparation method and application of Chinese magnolcavine fruit volatile oil microcapsule

A technology of Schisandra volatile oil and microcapsules, which is applied in the field of medicine, can solve the problems of less research on Schisandra volatile oil and no public literature reports, and achieve good thermal stability, solubility and dispersibility, significant antitussive effect, and rich sources of raw materials.

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Schisandra volatile oil, as a bioactive component of traditional Chinese medicine, has good development and application prospects, but at present, there are few researches on the volatile oil of Schisandra chinensis at home and abroad, and it has not been developed and utilized.
[0005] Through literature search, do not see the public literature report identical with the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] First, 36g of maltodextrin and whey protein with a mass ratio of 1:2 were used as wall materials, dissolved in 72ml of hot water at 60°C, and kept stirring to fully dissolve to obtain a wall material solution; then add 4g of The mixed emulsifier of monoglyceride and sucrose ester with a mass ratio of 1:1 is uniformly mixed, and finally 60g of the core material schisandra volatile oil is added to the above solution, stirred at a high speed of 10000r / min for 10min and then passed into a high-pressure homogenizer. Homogenize three times at 70°C and pressure 30MPa to form an emulsion with uniform particle size, spray dry under the conditions of inlet temperature of 150°C, outlet temperature of 80°C, and atomization pressure of 0.2MPa to obtain Schisandra volatile oil Capsules, the embedding rate is 92.6%.

Embodiment 2

[0016] First, 60g of maltodextrin and whey protein with a mass ratio of 1:1 are used as wall materials, dissolved in 180ml of hot water at 80°C, and stirred continuously to fully dissolve to obtain a wall material solution; then add 1g of The mixed emulsifier of monoglyceride and sucrose ester with a mass ratio of 1:1 is uniformly mixed, and finally 39g of the core material schisandra volatile oil is added to the above solution, stirred at a high speed of 12000r / min for 10min and then passed into a high-pressure homogenizer. Homogenize three times at 80°C and pressure 50MPa to form an emulsion with uniform particle size, and spray dry under the conditions of inlet temperature of 200°C, outlet temperature of 120°C, and atomization pressure of 0.5MPa to obtain Schisandra volatile oil Capsules, the embedding rate is 95.3%.

Embodiment 3

[0018] First, 48g of maltodextrin and whey protein with a mass ratio of 1:3 are used as wall materials, dissolved in 48ml of hot water at 60°C, and stirred continuously to fully dissolve to obtain a wall material solution; then add 2g of The mixed emulsifier of monoglyceride and sucrose ester with a mass ratio of 1:1 is uniformly mixed, and finally 50g of the core material volatile oil of Schisandra chinensis is added to the above solution, stirred at a high speed of 15000r / min for 10min and then passed into a high-pressure homogenizer. Homogenize three times at 75°C and pressure 40MPa to form an emulsion with uniform particle size, spray dry under the conditions of inlet temperature of 180°C, outlet temperature of 100°C, and atomization pressure of 0.3MPa to obtain Schisandra volatile oil Capsules, the embedding rate is 94.5%.

[0019] Application of schisandra volatile oil microcapsules in the preparation of medicines for treating acute and chronic coughs.

[0020] Grouping...

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Abstract

The invention discloses a preparation method and application of a Chinese magnolcavine fruit volatile oil microcapsule. The preparation method comprises the following steps: taking Chinese magnolcavine fruit volatile oil as a core material, preparing a wall material solution by taking maltodextrin and whey protein as raw materials, then adding a mixed emulsifying agent of monoglyceride and sucrose ester, further adding the core material, emulsifying, homogenizing and performing spray drying to obtain microcapsule particles. According to the preparation method disclosed by the invention, the Chinese magnolcavine fruit volatile oil is wrapped by the polymer material to form the microcapsule, so that the obtained product has relatively good water solubility and stability; pharmacodynamic evaluation proves that the microcapsule has an effect on relieving cough, and the efficacy is above 70% of that of codeine, so that the microcapsule can provide a preferred medicament for treating acute and chronic cough.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method and application of schisandra volatile oil microcapsules. Background technique [0002] Schisandra chinensis, commonly known as mountain pepper, weighing tuozi, medicine schisandra, noodle vine, five plums, etc., is the dry and mature fruit of the magnolia plant Schisandra chinensis. The medicinal value is extremely high, and it has the effects of nourishing qi, nourishing the kidney, astringing the lung, astringent essence, promoting body fluid, quenching thirst, improving intelligence and calming the nerves. The pulp and seeds of the medicinal parts of Schisandra chinensis are rich in volatile oil, especially the highest content in seeds, which can reach 1.6-2.9%. The volatile components mainly contain α -pinene, copaene, muskolene, β - pinene, β- Myrcene, α- Terpineol, bornyl acetate, ylangene and other substances. Pharmacological studie...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/79A61K36/57A61K9/50A61P11/14
CPCA61K36/79A61K9/5052A61K36/57
Inventor 张金芳杨存
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