Licorice flavonoids antitussive and application thereof

Abstract

The invention provides an application of licorice flavonoids in preparing antitussives for treating acute and chronic cough caused by a plurality of reasons. The related acute and chronic cough comprises cough symptoms caused by various diseases such as acute and chronic tracheitis, asthma, chronic obstructive disease of lung, idiopathic pulmonary fibrosis, tuberculosis, bacterial pneumonia, bronchiectasis and the like. The licorice flavonoids extracted from liquorice proves to have very strong effect in preventing cough according to pharmacological tests; drug potency thereof is similar to the drug potency of codein in narcotic antitussive; the function mechanism analyses indicate that the licorice flavonoids plays the role of preventing cough through the non-narcotic nerve centre. In addition, the licorice flavonoids extracted from natural plants can also be prepared into health food. The invention solves the problem that the non-narcotic potent antitussives are badly needed, provides a non-narcotic potent antitussives which has fine social and economical benefits.

Description

technical field [0001] The invention belongs to pharmaceutical preparations and uses, and relates to the pharmaceutical preparations and uses of licorice flavonoids, in particular to the application of licorice flavonoids in the preparation of medicines for treating acute and chronic coughs caused by various causes. Background technique [0002] In my country, licorice has a long history of medicinal use and has been widely used. Traditional medicine believes that it has the effects of benefiting qi and nourishing the middle, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and pain, and reconciling various medicines. There is a saying of "ten directions and nine herbs". Licorice is the root and rhizome of various plants of the leguminosae genus Glycyrrhiza Linn. According to the 2005 edition of the Pharmacopoeia of the People's Republic of China, there are three original plants, namely G.uralensis Fisch., G.inflate Bat, and G.glabraL. ...

AI Technical Summary

Problems solved by technology

Licorice flavonoids have been proved to have anti-tumor effects, anti-oxidation effects, anti-HIV effects, anti-ulcer effects, anti-arrhythmia effects and liver protection effects, etc., but there are few reports on whether licorice flavonoids can have antitussive effects, especially antitussive effects What is the material basis of What is the mechanism of action of the antitussive effect? And the study of preparing preparations with licorice flavonoids as antitussive medicine has not yet been reported.

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