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Pharmaceutical composition and technique of preparing the same

A composition and drug technology, applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve problems such as inconvenience in work and life, affecting life, etc., and achieve the effects of preventing sputum corruption, clearing nasal passages, and strong antitussive effect.

Inactive Publication Date: 2008-05-14
朱志宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such as Tylenol, Baijiahei, phenanmin, Likeshu, Ganmaotong, Suxiaowofeng Capsules, Ganmaoqing, etc., but because the cold medicines on the market have certain side effects, most of these cold medicines contain antihistamine flutter Ermin (chlorpheniramine maleate) or diphenhydramine hydrochloride, etc., can pass through the blood-brain barrier and produce a strong sedative effect, often accompanied by adverse reactions such as drowsiness and fatigue. It is recommended for patients who need to keep their minds clear Work and life bring inconvenience, more or less affect people's life, work and study

Method used

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  • Pharmaceutical composition and technique of preparing the same
  • Pharmaceutical composition and technique of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take by weighing levodropropizine 60g, guaiacol glyceryl ether 100g, pseudoephedrine hydrochloride 30g, be prepared into tablet as follows:

[0019] Weigh an appropriate amount of auxiliary materials lactose, hydroxypropylmethylcellulose, and magnesium stearate, and measure an appropriate amount of 75% ethanol, pulverize the above-mentioned raw materials and auxiliary materials, and sieve. First mix all auxiliary materials (except magnesium stearate), then add levodropropizine, guaiacol glyceryl ether and pseudoephedrine hydrochloride and mix evenly; then use 75% ethanol to make soft materials, granulate, bake, Then add magnesium stearate and mix well. That is to make plain tablets. Then weigh an appropriate amount of hydroxypropylmethylcellulose, titanium dioxide and polyethylene glycol to prepare a glue. Put the plain tablets in the coating pot, turn on the coating machine, preheat with hot air, start spraying the coating liquid mist, and dry with hot air while spra...

Embodiment 2

[0042] Take levodropropizine 30g, guaiacol glyceryl ether 190g, pseudoephedrine sulfate 20g, prepare oral liquid as follows:

[0043]Weigh or measure an appropriate amount of auxiliary materials such as ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, aspartame, methyl cellulose, lemon, etc., crush and sieve the raw and auxiliary materials respectively for later use. Add ethanol to the prepared raw and auxiliary materials, stir and dissolve, and add water to 1000ml to obtain.

Embodiment 3

[0045] Weigh an appropriate amount of levodropropizine, guaiacol glyceryl ether, and pseudoephedrine hydrochloride, and prepare micropill capsules as follows:

[0046] Weigh an appropriate amount of sodium hydroxymethyl starch, sodium lauryl sulfate, sucrose, hydroxypropylmethylcellulose, starch and magnesium stearate. Use dilute ethanol as a wetting agent for the starch, and form a pill, and take a ball core with a size of 20 to 35 mesh for later use. Spray the surface of the ball core with 2% ethanol solution of hydroxymethyl starch sodium, add the mixed levodropropizine, microcrystalline cellulose and talcum powder to make it adhere to the surface of the ball core, and blow it to the surface of the ball core with hot air. The surface is dry and placed in an oven to dry for later use. Pills containing pseudoephedrine hydrochloride and guaiacol glycerin were made in the same way. All three are selected from 20-35 mesh size pills containing pills and their contents are deter...

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PUM

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Abstract

The invention provides a drug composition with the active components of levodropropizine, guaifenesin and pseudoephedrine or acceptable salts on the drugs and a preparation method, which is used for treating nasopharynx mucosa hyperemia, nasal obstruction, sneeze, snivel caused by cold and other diseases, cough and expectoration and other symptoms caused by bronchitis. Compared with the common used centrally antitussive drugs on market, the peripherally antitussive drugs of levodropropizine adopted by the invention have the advantages of obvious antitussive effect and less adverse reaction.

Description

field of invention [0001] The invention belongs to the field of chemical medicines, and relates to a pharmaceutical composition with levodropropizine, guaiacol glyceryl ether, pseudoephedrine or a pharmaceutically acceptable salt thereof as active ingredients and a preparation process thereof, which can be used for treating colds, etc. Nasopharyngeal mucosa congestion, nasal congestion, sneezing, runny nose caused by diseases, cough, sputum and other symptoms caused by bronchitis. Background technique [0002] Influenza is a common disease and frequently-occurring disease. In daily life, almost no one does not experience the pain caused by cold. The main symptoms of cold are: fever, chills, high fever, sneezing, runny nose, nasal congestion, cough, expectoration, general Weakness etc., these discomforts affect people's life, work and study. Cough and sputum are also common clinical symptoms of respiratory diseases. These diseases increase the suffering of patients, seriousl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/495A61K9/08A61K9/10A61K9/20A61K9/48A61K9/52A61P11/02A61P11/14A61K31/137A61K31/085
Inventor 朱志宏
Owner 朱志宏
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