Licorice flavonoids antitussive and application thereof
A technology of licorice flavonoids and preparations is applied in the field of pharmaceutical preparations to achieve good social and economic benefits and the effects of strong antitussive effect
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Embodiment 1
[0017] 1. Pharmacodynamics test
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[0018] We first simulated clinical cough symptoms and established 2 kinds of guinea pig cough animal models. After applying the model research, we found that the medicine prepared by licorice flavonoids of the present invention can inhibit citric acid or Capsaicin-induced cough reflex in guinea pigs, giving lysergide (Methysergide, 5-hydroxytryptamine receptor blocker) 3mg / kg (ip) in advance can block the inhibitory effect of licorice flavonoids on citric acid-induced guinea pig cough reflex; Lebenclamide (Glibenclamide, an ATP-sensitive potassium ion channel blocker) 20mg / kg (ip) slightly weakened the inhibitory effect of licorice flavonoids on citric acid-induced cough reflex in guinea pigs. Naloxone (Naloxone, opioid receptor blocker) 0.3mg / kg (ip) can not block the inhibitory effect of licorice flavonoids on citric acid-induced cough reflex in guinea pigs, while naloxone can block the effect of licorice flavones on citric acid Inhibition of the induced cough reflex in guin...
Embodiment 2
[0074] Embodiment 2 licorice flavonoid preparation
[0075] 1 prescription (Licorice Flavone Capsules)
[0076] Licorice Flavonoids 300g
[0077] Starch 32g
[0078] Hydroxypropyl Cellulose (L-HPC) 6g
[0079] Micronized silica gel 4.5g
[0080] Magnesium Stearate 1.5g
[0081] Appropriate amount of starch slurry (10%)
[0082]
[0083] Makes 1000 capsules
[0084] 2 Prescription basis and prescription screening process
[0085] 2.1 Prescription Basis
[0086] Formulate licorice flavonoid capsules according to pharmacodynamic tests, specifications: licorice flavonoid content 300mg / capsule.
[0087] The starch in this prescription is corn starch, which has good color, weak hygroscopicity, large output and low price; it is white fine powder, insoluble in water and ethanol, very stable in the air, ineffective with most drugs, hygroscopic and not deliquescent , water-swellable, is the most widely used diluent and disintegrant, and is main...
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