The invention provides a method and a
system TGrKCMI for predicting interaction between circRNA (Ribonucleic Acid) and miRNA (Micro Ribonucleic Acid). According to the method, a pre-training model is used for extracting sequence features of circRNA and miRNA, and redundant information is reduced through PCA dimension reduction; then, a multi-head attention module with a gating mechanism is introduced to
encode sequence features, and the expression ability of key information is enhanced; on the basis, a circRNA-miRNA interaction diagram is constructed, and robust diagram
feature learning is realized in combination with diagram attention
convolution of random feature masks. And finally, a kernel-based adaptive
nonlinear classifier is adopted to carry out modeling on the fusion features, and high-precision and high-robustness interaction prediction is realized.