Application of resveratrol in drug for treating bacterial pneumonia

A resveratrol and bacterial technology, applied in the field of medicine, can solve the problems of limited dosage, poor therapeutic effect, and single route of administration, and achieve remarkable antibacterial effect and remarkable effect of inhalation therapy

Inactive Publication Date: 2019-01-04
SHANGHAI YANGPU CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide the application of resveratrol in the medicine that is used for the treatment of bacterial pneumonia, to solve clinical treatment of bacterial pneumonia single administration route, limited drug distribution to the lungs, poor therapeutic effect, Disadvantages of long duration

Method used

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  • Application of resveratrol in drug for treating bacterial pneumonia
  • Application of resveratrol in drug for treating bacterial pneumonia
  • Application of resveratrol in drug for treating bacterial pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Embodiment 1. resveratrol DPPC liposome

[0044] Take 4mg of resveratrol, 40mg of DPPC, and 135mg of cholesterol in an eggplant-shaped flask, add an appropriate amount of mixed solvent of ethanol and ether to dissolve completely, and rotatively evaporate in a water bath at 60°C to remove the organic solvent, forming a thin layer on the inner wall of the eggplant-shaped flask Uniform film; add 40ml of pH7.4 phosphate buffer solution into an eggplant-shaped flask, place it at 37°C at 150 rpm and shake for 15 minutes to fully hydrate it, take it out and ultrasonically disperse it for 10 minutes to obtain resveratrol DPPC Liposomes. The particle size measurement results showed that most of the particles were below 200nm. Under the transmission electron microscope, the distribution of resveratrol DPPC liposomes is relatively uniform, most of them are spherical, and the multivesicle structure ( figure 1 ). It is 191.5nm ( figure 2 ), the PDI is 0.26, and the particle s...

Embodiment 2

[0045] Embodiment 2. Resveratrol solid lipid nanoparticles

[0046] Take 0.1g of resveratrol, 2.0g of cetyl palmitate, and 0.4g of caprylic / capric glyceride in a water bath at 53°C until melted, mix with 1.0g of resveratrol as the oil phase, and inject Use 1.5g of soybean lecithin, 1.8g of polyoxyethylene 660-12 hydroxystearate, add 100mL of water for injection, stir and dissolve, heat to 53°C, and use it as the water phase; under the conditions of stirring and nitrogen, add the water phase dropwise to In the oil phase at the same temperature, continue to stir for a certain period of time to form colostrum, sonicate the probe for 5 minutes, stir at 0-2°C for 2 hours, and filter through 0.22 μm micropores to obtain resveratrol solid lipid nanoparticles. Observed under a scanning transmission electron microscope, most of them are particles below 100 nanometers.

Embodiment 3

[0047] Example 3. Resveratrol Phospholipid Complex

[0048] Dissolve 25 mg of resveratrol and 50 mg of phospholipid together in an appropriate amount of ethanol mixed solvent, ultrasonically dissolve to form a clear solution, and rotary evaporate in a water bath at 40°C to remove the ethanol solvent to obtain the resveratrol phospholipid complex.

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Abstract

The invention relates to the technical field of medicines and aims to provide an application of resveratrol in a drug for treating bacterial pneumonia so as to overcome the defects that the clinical drug delivery route is single, the dose of the drug distributed to lungs is limited, the treatment effect is poor and the course of disease is long.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of resveratrol in medicine for treating bacterial pneumonia. Background technique [0002] The main pathogenesis of bacterial pneumonia is that bacteria release a large amount of endotoxin, causing excessive and uncontrolled inflammatory responses and imbalance of pro-inflammatory and anti-inflammatory responses, and diseased macrophages release pro-inflammatory factors such as IL-6 and TNF-α, resulting in lung tissue damage , edema, surfactant inactivation and hyaline film formation. [0003] At present, the clinical treatment of bacterial pneumonia mainly focuses on actively treating the primary disease, controlling infection, and eliminating inflammation. Attempts have been made both at home and abroad to reduce the pulmonary inflammatory response against the main pathogenesis. The main methods are: 1. Intravenous antibiotics: Antibiotics have th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61K9/72A61P11/00A61P31/04
CPCA61K9/0073A61K31/05A61P11/00A61P31/04
Inventor 朱李飞余自成陈红君马明华
Owner SHANGHAI YANGPU CENT HOSPITAL
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