Application of pulsatilla saponin B4 in preparation of drug for treating/preventing bacterial pneumonia

A kind of Pulsatilla saponin and bacterial technology, which is applied to Pulsatilla saponin B4 in the field of preparing medicines for treating/preventing bacterial pneumonia
CN111249291AActive Publication Date: 2020-06-09广西馨海药业科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广西馨海药业科技有限公司
Publication Date
2020-06-09

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Abstract

The invention discloses an application of pulsatilla saponin B4 in preparation of a drug for treating / preventing bacterial pneumonia, induced by klebsiella pneumoniae, of mammals including human being. The pulsatilla saponin B4 has a protecting function on bacterial pneumonia induced by klebsiella pneumoniae, a protecting mechanism can be related to reduction of the content of inflammatory factorsIL-6, IL-1beta and TNF-alpha, the content of MPO, IL-6 and TNF-alpha in lung tissue and the number of neutrophile granulocyte and leukocyte in plasma, and the pulsatilla saponin B4 for injection hasa better effect than a positive drug.
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Description

technical field

[0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to the use of Pulsatilla saponin B4 in the preparation of medicines for treating / preventing bacterial pneumonia. Background technique

[0002] Pneumonia is usually caused by a viral or bacterial infection, and occasionally by other microorganisms. Klebsiella pneumoniae is the main opportunistic pathogen causing community-acquired pneumonia, and it is also the main patient of nosocomial infection. Klebsiella pneumoniae can induce various diseases such as pneumonia, urinary tract infection, sepsis and sepsis, among which Klebsiella pneumoniae-induced pneumonia is the most common disease. Due to the high variability and drug resistance of Klebsiella pneumoniae, the drugs for treating Klebsiella pneumoniae infection are decreasing day by day, seriously affecting the quality of life and health of human beings, and patients with Klebsiella pneumoniae ...

Claims

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