Application of pulsatilla saponin B4 in preparation of drug for treating/preventing bacterial pneumonia

A kind of Pulsatilla saponin and bacterial technology, which is applied to Pulsatilla saponin B4 in the field of preparing medicines for treating/preventing bacterial pneumonia

Active Publication Date: 2020-06-09
广西馨海药业科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Pulsatilla saponin B4 is a pharmacologically active pentacyclic triterpenoid saponin extracted from the perennial herb Pulsatilla chinensis of the family Ranunculaceae. It has pharmacological effects such as immune regulation, anti-tumor, and anti-oxidation. see the report

Method used

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  • Application of pulsatilla saponin B4 in preparation of drug for treating/preventing bacterial pneumonia
  • Application of pulsatilla saponin B4 in preparation of drug for treating/preventing bacterial pneumonia
  • Application of pulsatilla saponin B4 in preparation of drug for treating/preventing bacterial pneumonia

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Embodiment Construction

[0017] The present invention will be further described in detail below in combination with details, so that those skilled in the art can implement it with reference to the description.

[0018] It should be understood that terms such as "having", "comprising" and "including" as used herein do not entail the presence or addition of one or more other elements or combinations thereof.

[0019] It should be noted that the experimental methods described in the following embodiments, unless otherwise specified, are conventional methods, and the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0020] 1. Materials

[0021] 1.1 Experimental animals

[0022] 120 healthy BALB / c mice, SPF grade, weighing 20±2g, provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., animal certificate number: SCXK Beijing 2016-0006.

[0023] 1.2 Drugs and reagents

[0024] Pulsatilla saponin B4 for injection, hereinafter referred to as B...

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Abstract

The invention discloses an application of pulsatilla saponin B4 in preparation of a drug for treating/preventing bacterial pneumonia, induced by klebsiella pneumoniae, of mammals including human being. The pulsatilla saponin B4 has a protecting function on bacterial pneumonia induced by klebsiella pneumoniae, a protecting mechanism can be related to reduction of the content of inflammatory factorsIL-6, IL-1beta and TNF-alpha, the content of MPO, IL-6 and TNF-alpha in lung tissue and the number of neutrophile granulocyte and leukocyte in plasma, and the pulsatilla saponin B4 for injection hasa better effect than a positive drug.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to the use of Pulsatilla saponin B4 in the preparation of medicines for treating / preventing bacterial pneumonia. Background technique [0002] Pneumonia is usually caused by a viral or bacterial infection, and occasionally by other microorganisms. Klebsiella pneumoniae is the main opportunistic pathogen causing community-acquired pneumonia, and it is also the main patient of nosocomial infection. Klebsiella pneumoniae can induce various diseases such as pneumonia, urinary tract infection, sepsis and sepsis, among which Klebsiella pneumoniae-induced pneumonia is the most common disease. Due to the high variability and drug resistance of Klebsiella pneumoniae, the drugs for treating Klebsiella pneumoniae infection are decreasing day by day, seriously affecting the quality of life and health of human beings, and patients with Klebsiella pneumoniae ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P31/04A61P11/00
CPCA61K31/704A61P31/04A61P11/00Y02A50/30
Inventor 杨世林
Owner 广西馨海药业科技有限公司
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