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Application of acetylshikonin in preparation of medicine for resisting lung inflammatory factor storm

A technology of acetylshikonin and lung inflammation, which is applied in the field of medicine and can solve problems such as the storm effect of acetylshikonin on cell inflammatory factors that have not been shown by research

Pending Publication Date: 2022-03-11
ZHENGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of acetylshikonin in the anti-inflammatory cytokine storm of the lung, that is, no research has shown the role of acetylshikonin in the treatment of inflammatory cytokine storm

Method used

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  • Application of acetylshikonin in preparation of medicine for resisting lung inflammatory factor storm
  • Application of acetylshikonin in preparation of medicine for resisting lung inflammatory factor storm
  • Application of acetylshikonin in preparation of medicine for resisting lung inflammatory factor storm

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Experimental program
Comparison scheme
Effect test

Embodiment

[0026] Materials and Methods

[0027] 1 material

[0028] 1.1.1 Acetylshikonin

[0029] The acetylshikonin used in the present invention was purchased from Wuhan ChemFaces Company with a purity of 97%.

[0030] 1.1.2 Reagents and cells

[0031] DMEM medium and FBS were purchased from BI Company,

[0032] RAW264.7 cells were purchased from Nanjing Kebai Biotechnology Co., Ltd.

[0033] poly(I:C) was purchased from Invivogen,

[0034] SARS-CoV-2 spike protein was purchased from GenScript,

[0035] BALB / c mice were purchased from Weitong Lihua Company,

[0036] LEGENDplex TM Mouse cytokine detection kit was purchased from Biolegend,

[0037]Red blood cell lysate was purchased from Suleibao Company.

[0038] 1.1.3 Instruments and equipment

[0039] Microplate reader (BD company); Inverted microscope (OLYPUMS);

[0040] Haier Medical Low Temperature Storage Box (Qingdao Haier Special Electric Co., Ltd.);

[0041] Analytical balance (Mettler-Toledo Instruments Shanghai ...

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Abstract

The invention relates to an application of a compound acetylshikonin in preparation of a medicine for resisting lung inflammatory factor storm, namely an inhibition effect of acetylshikonin on mouse acute lung injury and inflammatory factor storm induced by polyinosinic-cytidylic acid and SARS-CoV-2 spinous process protein. The compound acetylshikonin can inhibit inflammatory factors induced by polyinosinic-cytidylic acid and SARS-CoV-2 spinous process protein, obviously inhibits expression of interleukin IL-6 in inflammatory reaction, and can be further applied to research and development of drugs for treating or preventing lung inflammation. The acetylshikonin is suitable for treating lung inflammatory factor storm and acute lung injury caused by viral pneumonia, bacterial pneumonia, mycoplasma pneumonia and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of acetylshikonin in the preparation of anti-pulmonary inflammatory factor storm medicine. Background technique [0002] Cytokine storm refers to a variety of cytokines in body fluids such as TNF-α, IL-1, IL-6, IL-12, IFN-α, IFN-β, IFN-γ, MCP after the body is infected with microorganisms The rapid and massive production of IL-1 and IL-8 is an important cause of acute respiratory distress syndrome and multiple organ failure. [0003] Pneumonia is one of the common international epidemic diseases and a public health problem that threatens human health around the world. The first symptoms are mainly shortness of breath, dyspnea, fever, and cough. In severe cases, it can lead to severe respiratory syndrome, renal failure and even death. Pneumonia mainly includes viral pneumonia, bacterial pneumonia and mycoplasma pneumonia. Viral pneumonia such as coro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/222A61K36/30A61P11/00A61P31/12A61P31/04
CPCA61K31/222A61K36/30A61P11/00A61P31/12A61P31/04
Inventor 董子钢刘康栋顾廷轩赵冉赵四敏晋果果
Owner ZHENGZHOU UNIV
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