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Adsorbent for removing inflammatory factors in blood of patient with inflammatory reaction on whole body and preparation method thereof

A technology of systemic inflammatory response and inflammatory factors, applied in blood circulation treatment, chemical instruments and methods, suction devices, etc., can solve the problems of high price and poor removal effect, achieve high mechanical strength, improve adsorption capacity, high physical and chemical The effect of stability

Active Publication Date: 2017-01-18
浙江瓯宇生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among such foreign products, for example, Japan’s perfusion device using polymyxin B ligand can be used for the treatment of sepsis, but the product is expensive and has toxic effects caused by ligand shedding, so it has not yet entered my country market
The Cytosorb product in the United States is also an adsorbent product for cytokine removal, which has a better effect, but its effect on TNF-a with a larger molecular weight is poor, but it has not yet entered the Chinese market

Method used

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  • Adsorbent for removing inflammatory factors in blood of patient with inflammatory reaction on whole body and preparation method thereof
  • Adsorbent for removing inflammatory factors in blood of patient with inflammatory reaction on whole body and preparation method thereof
  • Adsorbent for removing inflammatory factors in blood of patient with inflammatory reaction on whole body and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of Mesoporous Adsorbent with Nanocomposite Structure

[0025] Add 1.0g of nano-calcium carbonate with a particle size of 50-100nm into 20g of styrene and 60g of divinylbenzene in a 500mL beaker, use an ultrasonic cell disruptor to sonicate for 30min, then add 0.8g of benzoyl peroxide, and stir to It was dissolved, and after it was completely dissolved, 30 g of toluene, 60 g of gasoline and 30 g of isopropanol were added thereto, and fully mixed to obtain an organic phase. At normal temperature, add 8g of polyvinyl alcohol and 800mL of deionized water into a 2000mL three-necked flask to form an aqueous solution of 0.5% (mass fraction) of polyvinyl alcohol, and heat and stir to 45°C to fully dissolve the polyvinyl alcohol to obtain Water phase; stop stirring, add the obtained uniformly mixed organic phase into the water phase, start the stirrer, adjust the stirring rate, so that the droplets are evenly distributed, and after the temperature is raised to 50°C, ...

Embodiment 2

[0027] Preparation of Mesoporous Adsorbent with Nanocomposite Structure

[0028] Put 1.25g of nano-calcium carbonate with a particle size of 80-150nm and 12.5g of styrene and 67.5g of divinylbenzene in a 500mL beaker, and after ultrasonicating for 30min with an ultrasonic cell disruptor, add 1.6g of benzoyl peroxide to it, and stir Make it dissolve, and after the dissolution is complete, add 30 g of toluene, 15 g of gasoline, and 30 g of isopropanol thereinto, and ultrasonicate for 30 min with an ultrasonic cell disruptor to obtain an organic phase. At room temperature, add 9.6g of polyvinyl alcohol and 640mL of deionized water into a 2000mL three-neck flask to form an aqueous solution of 1.0% (mass fraction) of polyvinyl alcohol, and heat and stir to 50°C to fully dissolve the polyvinyl alcohol. Obtain the water phase; stop stirring, add the obtained uniformly mixed organic phase into the water phase, start the agitator, adjust the stirring speed to disperse the oil droplets,...

Embodiment 3

[0030] Preparation of Mesoporous Adsorbent with Nanocomposite Structure

[0031]Add 1.5g of nano-calcium carbonate with a particle size of 30-50nm and 15g of styrene and 80g of divinylbenzene in a 500mL beaker, and after ultrasonicating for 30min with an ultrasonic cell disintegrator, add 1.2g of benzoyl peroxide to it, and stir to make it Dissolve, and after the dissolution is complete, add 55g of toluene, 55g of gasoline, and 55g of n-butanol to it to obtain an organic phase. At normal temperature, add 16.8g of polyvinyl alcohol and 840mL of deionized water into a 2000mL three-necked flask to form a 2.0% (mass fraction) aqueous solution of polyvinyl alcohol, and heat and stir to 45°C to fully dissolve the polyvinyl alcohol. Obtain the water phase; stop stirring, add the obtained uniformly mixed organic phase into the water phase, start the agitator, adjust the stirring speed to disperse the oil droplets, raise the temperature to 78°C at a speed of 2°C / 5min, and make the liqu...

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Abstract

The invention relates to an adsorbent for removing inflammatory factors in blood of a patient with inflammatory reaction on the whole body through blood or plasma perfusion and a preparation method thereof. The adsorbent is a nano composite structure adsorbent, is a cell factor adsorbent prepared by using nano calcium carbonate-styrene-divinylbenzene as a basic framework, using toluene, gasoline and a multi-carbon alcohol mixture as pore-foaming agents and using benzoyl peroxide as an initiator and has a developed mesoporous structure and high specific surface area. By introducing the nano material, the efficiency of removing the inflammatory factors in blood or blood plasma of the adsorbent is greatly improved. The adsorbent is simple to prepare, has the efficient removal effect on inflammation factors such as IL-6, TNF-alpha, IL-beta 1 and IL-8 and is used for removing the excessive pathogenic inflammatory factors in the patient body in a blood or blood plasma perfusion mode.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of biomedicine. The invention relates to an adsorbent used for hemoperfusion to remove inflammatory factors in the blood of patients with systemic inflammatory response and a preparation method thereof. [0003] technical background: [0004] Various forms of shock, trauma or infection may lead to the activation of corresponding cell components (such as neutrophils, macrophages, endothelial cells, etc.) Damage tissue, leading to multiorgan failure or septic shock. [0005] In my country, the abuse of antibiotics and environmental pollution have led to the acceleration of the mutation frequency of bacteria and viruses. Many viral and bacterial infectious diseases have developed into sepsis due to lack of timely treatment, and eventually lead to multiple organ failure and death. There are more than 18 million cases of severe sepsis every year in the world, and there are millions of sepsis patients in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCA61M1/3679B01J20/043B01J20/261B01J20/28021B01J20/28064B01J20/28066B01J20/28083B01J2220/46B01J2220/4806B01J2220/4812
Inventor 欧来良柴雅敏陈建
Owner 浙江瓯宇生物有限公司
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