Compound with effects of resisting inflammation and platelet activation and aggregation as well as preparation method and application thereof

An anti-platelet and compound technology, applied in the direction of steroids, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve the problems of limited research on the mechanism of pharmacological action, and achieve a significant anti-platelet-related inflammation effect
CN102120752AInactive Publication Date: 2011-07-13THE SECOND AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE SECOND AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV
Publication Date
2011-07-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a compound with effects of resisting inflammation and platelet activation and aggregation as well as a preparation method and application thereof. The compound has the structure of (25R)-26-oxy-beta-D-glucopyranose-5alpha-furostanol-3beta,12beta,22,26-tetraalcohol-3-oxy-beta-D-glucopyranose(1->2)[beta-D-glucopyranose(1->3)]-beta-D-glucopyranose(1->4)-beta-D-galapyranoside. The effects of the compound in the field of cardial vessels are comprehensively researched from platelet aggregation, platelet activation, platelet calcium ion variation, platelet activation signal transduction pathway and expression of platelet activation relevant inflammatory factors in the invention for the first time. Results show that the compound is a substance found to be with a strong effect on resisting platelet aggregation so far in the allium macrostemon saponin compounds, which has the stronger effect than that of aspirin with the same concentration; and the compound simultaneously has an obvious effect on resisting relevant platelet inflammations. The compound provided by the invention can be applied to medicines for treating thrombus and atherosclerosis.
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Description

technical field

[0001] The invention relates to a compound with anti-platelet activation, aggregation and inflammation and its preparation method and application, which is suitable for preparing medicines for treating thrombus and atherosclerosis. It belongs to the technical field of biological and chemical drugs. Background technique

[0002] With the aging of society and the improvement of living standards, the incidence and mortality of cardiovascular and cerebrovascular diseases in my country are increasing day by day. The main cause of cardiovascular and cerebrovascular diseases is due to the formation of thrombus in blood vessels, and the clinical manifestations are acute myocardial infarction, cerebral thrombosis, stroke and vascular embolism. Thrombosis is not an independent clinical disease. It is the cause or complication of many diseases, such as atherosclerosis, coronary heart disease, cerebrovascular disease, deep vein thrombosis after surgery or trauma, and pu...

Claims

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