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Novel clinical application of minor radix buplenri granules and antibiotics

A technology of Bupleurum and its composition, which is applied in the field of traditional Chinese medicine composition—Xiaochaihu granules combined with antibiotics, which can solve unclear problems

Inactive Publication Date: 2020-07-31
GUANGZHOU BAIYUSN GUANGHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no clear report that Xiaochaihu granules can treat carbapenem-resistant Klebsiella pneumoniae infection. As for whether it can be used in combination with antibiotics to inhibit CRKP for clinical application, although there are reports that it can be used in combination with antibiotics, but How to use it, the mechanism and which ones are really effective in combination with antibiotics, and which diseases are effective, in view of the complexity of disease treatment, it is not clear at present

Method used

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  • Novel clinical application of minor radix buplenri granules and antibiotics
  • Novel clinical application of minor radix buplenri granules and antibiotics
  • Novel clinical application of minor radix buplenri granules and antibiotics

Examples

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Effect test

Embodiment 1

[0027] Example 1: Anti-CRKP investigation of Xiaochaihu granules combined with AMK, IPM, LVF, and SCF in vitro. The minimum inhibitory concentration (MIC) of Xiaochaihu granule liquid and four kinds of antibiotics to CRKP was determined by adopting test tube double dilution method, and then the MIC of each combined drug was determined by checkerboard method to investigate the effect of Xiaochaihu granule solution on AMK, IPM, and CRKP. , LVF, SCF anti-CRKP sensitization.

[0028] 1. Experimental materials:

[0029] 1.1 Test drug: Xiaochaihu Granules (sugar-free, Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.).

[0030] 1.2 Control drugs: amikacin (AMK), imipenem (IPM), levofloxacin (LVF), cefoperazone-sulbactam (SCF).

[0031] 1.3 Experimental strains:

[0032] The clinical isolates of carbapenem-resistant Klebsiella pneumoniae (CRKP, M1) and the standard strain of Klebsiella pneumoniae (ATCC700603) were provided by the Clinical Microbiology Department of the First ...

Embodiment 2

[0053] Example 2: Investigation of the effect of Xiaochaihu Granules combined with AMK, IPM, LVF, and SCF on CRKP-infected pneumonia in rats.

[0054] By using the CRKP-infected pneumonia rat model to conduct experiments, the combination of Xiaochaihu granules with AMK, IPM, LVF, and SCF was used to improve the pneumonia of CRKP-infected rats, and it was found that Xiaochaihu granules had a sensitizing effect on antibiotics against CRKP.

[0055] 1.1 Test drug: Xiaochaihu Granules (sugar-free, Guangzhou Baiyunshan Guanghua Pharmaceutical Co., Ltd.).

[0056] 1.2 Control drugs: amikacin (AMK), imipenem (IPM), levofloxacin (LVF), cefoperazone-sulbactam (SCF).

[0057] 1.3 Experimental strains:

[0058] The clinical isolates of carbapenem-resistant Klebsiella pneumoniae (CRKP, M1) were provided by the Clinical Microbiology Department of the First Affiliated Hospital of Sun Yat-sen University, and were confirmed to be resistant to Medicinal properties.

[0059] 1.4 Experimental...

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Abstract

The invention relates to a novel clinical application of minor radix buplenri granules. The invention further discloses an application of the minor radix buplenri granules or the minor radix buplenrigranules and amikacin in preparation of drugs for preventing and treating carbapenem-resistant klebsiella pneumoniae infection. It is found that the minor radix buplenri granules can be combined withthe amikacin in antibiotics to improve the antibacterial effect on CRKP, have the sensitization effect and can serve as a natural antibiotic sensitizer. The combined use of the minor radix buplenri granules and the amikacin can enhance the clinical treatment on the CRKP infection, and especially has good antibacterial effect and sensitization effect on bacterial pneumonia caused by the CRKP.

Description

technical field [0001] The invention belongs to the field of Chinese patent medicines, and relates to a new application of a traditional Chinese medicine composition-Xiabupleurum granules combined with antibiotics. Background technique [0002] Klebsiella pneumoniae (KP) is a Gram-negative bacillus widely distributed in water and soil in nature. Pneumonia, meningitis, urinary system infection, sepsis and other infectious diseases are one of the important pathogenic bacteria of hospital infection. Carbapenem-resistant Klebsiella Pneumoniae (CRKP) can produce extended-spectrum β-lactamases (ESBLs). ESBLs are plasmid-mediated β-lactamases that can hydrolyze oxyimino-β-lactams and monoacylcyclic antibiotics, and can catalyze the synthesis of penicillins, cephalosporins, and monocyclic β-lactams. Hydrolysis, and can make CRKP cross-resistance to fluoroquinolones, aminoglycosides and sulfonamides. In addition, plasmids can be transferred and spread among bacterial strains, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K31/7036A61P31/04A61P11/00
CPCA61K31/7036A61K36/233A61K36/344A61K36/484A61K36/539A61K36/725A61K36/8888A61K36/9068A61P11/00A61P31/04A61K2300/00
Inventor 刘宏江志强张俊华郑如文徐煜耀毕聪何逸禧杜海泳
Owner GUANGZHOU BAIYUSN GUANGHUA PHARMA
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