50 results about "Carbapenem resistant" patented technology

The present invention relates to an antibacterial composition for combating carbapenem-resistant gram-negative bacteria comprising adenylate kinase (ADK) protein, which is derived from Mycobacterium tuberculosis, as an active ingredient. The ADK protein derived from Mycobacterium tuberculosis according to the present invention has an outstanding antibacterial activity against carbapenem-resistantgram-negative bacteria, and can beneficially be used in various fields as an antibacterial composition.

The invention provides a structural general formula (shown in the description) of a fluorescent probe for carbapenem type antibiotic bacteria. In the structural general formula, X represents carbon atoms or sulfur atoms; when the X represents CH, R1 represents methyl and can be of the configuration S or R, or the X represents CH2 or S; Y represents oxygen atoms, sulfur atoms or linkers on a fluorophorearomatic nucleus and comprises 4-hydroxymethylbenzyl or 4-hydroxyl or sulfydrylbenzyl or carbamate linkers. The synthesis method of the fluorescent probe comprises the following steps that 1, a compound 2 is prepared; 2, intermediates 3 and 4 are prepared; 3, a compound 5 is prepared; 4, a compound 6 is prepared; 5, a compound 7 is prepared; 6, a compound 8 is prepared; 7, a compound 9 is prepared; 8, a compound 10 is prepared;9, a compound CPC-1, namely a fluorescent probe compound is prepared. The fluorescent probe can be applied to detection of carbapenemases and drug-resistant bacteria containing the carbapenemases and has the important significance on antibiotic abandoning or few antibiotics adopted in medical treatment.

The application of nitrogen heterocyclic carbene selenium-gold compound in the preparation of novel antibacterial drugs against carbapenem-resistant Acinetobacter baumannii infection belongs to the technical field of drug preparation. The nitrogen heterocyclic carbene selenium-gold compound replaces the thiosugar ligand in the auranofin structure with a selenium-containing imidazole nitrogen heterocyclic carbene selenium, and the reactivity of Au-Se in the nitrogen-heterocyclic carbene selenium-gold compound is higher than that of Au- The S bond can avoid to a certain extent the problem that the Au‑S bond in the auranofin structure is easily destroyed by reducing thiols, and is metabolized before reaching the target, resulting in toxic and side effects. In vitro antibacterial activity revealed that compounds H7 and H8 inhibited the IC of carbapenem-resistant Acinetobacter baumannii 50 are 3.34 and 4.67 μM, MIC is 10 μM, and MBC is 20 μM. Administration in animals also shows good anti-drug-resistant bacteria effect, can significantly prolong the survival time of mice infected with drug-resistant bacteria, and has important practical application value.

Provided is an antibacterial composition against carbapenem-resistant gram-negative bacteria which includes, as an active ingredient, adenylate kinase (ADK) protein derived from Mycobacterium tuberculosis. The ADK protein derived from Mycobacterium tuberculosis, according to the subject matter, has excellent antimicrobial activity against carbapenem-resistant gram-negative bacteria, and thus may be usefully used in a variety of fields as an antibacterial composition.

The invention belongs to the technical field of bacteria detection, and in particular relates to a color-developing plate for screening Enterobacteriaceae bacteria resistant to carbapenem antibiotics. The chromogenic plate contains a specific chromogenic substrate and a selective medium; wherein, the selective medium includes the following components: yeast extract, salicin, gum arabic, sodium citrate, folic acid, vitamin B1, vitamin E. The chromogenic plate can be used for rapid screening of clinical carbapenem-resistant strains, and has a high accuracy rate.

The invention discloses a composition for treating carbapenem antibiotic resistant acinetobacter baumannii infection. The inventor studies and finds that a combination of sulbactam and ceftazidime ina specific ratio has an excellent treatment effect on CR-Ab infection, and the treatment effect of the combination is even better than that of a composition of carbapenem and sulbactam.

Disclosed in the present invention is a carbapenem antibiotic-tolerant pathogenic bacterium fluorescent probe with a structural general formula as represented by general formula I. The synthesis method for the fluorescent probe comprises the steps of: (1) preparation of a compound 3; (2) preparation of a compound 4; and (3) preparation of a fluorescent probe CVB-1. The fluorescent probe can be made into a test paper, kits or detection chips to be applied to the detection of carbapenemases and carbapenem drug-tolerant bacteria. Carbapenemases are detected or distinguished by determining whether the fluorescence intensity or colour of the fluorescent probe changes or not, and accordingly, pathogenic drug-tolerant bacteria expressing carbapenemases can be detected rapidly. The fluorescent probe guides the reasonable utilization of antibiotic drugs in terms of treatment or clinical application, and has important significance in terms of using no or less antibiotic drugs.