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Tea tree oil clathrate powder inhalation and application thereof to treatment of infected pneumonia

A technology of tea tree oil and clathrate, which is applied in the field of biomedicine, can solve the problems that the atomization device is complicated, can only be used in hospitals or at home, and is not suitable for carrying around, and achieves the effect of strong killing effect and strong antibacterial effect

Inactive Publication Date: 2016-02-17
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, atomization devices are generally complicated and can only be used in hospitals or at home, and are not suitable for carrying around

Method used

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  • Tea tree oil clathrate powder inhalation and application thereof to treatment of infected pneumonia
  • Tea tree oil clathrate powder inhalation and application thereof to treatment of infected pneumonia
  • Tea tree oil clathrate powder inhalation and application thereof to treatment of infected pneumonia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1. grinding method prepares tea tree oil clathrate

[0035] Dissolve 1g of tea tree oil in 1ml of ethanol solution; weigh 5.6g of β-cyclodextrin in a mortar, add 5ml of water and grind it evenly, then add tea tree oil alcohol solution dropwise while grinding, grind to a paste, dry at room temperature and use Wash with 2 ml of ethyl acetate, and dry in vacuum at 40° C. for 2 hours to obtain tea tree oil clathrate.

Embodiment 2

[0036] Embodiment 2. Saturated aqueous solution method prepares tea tree oil clathrate

[0037] Add 5.6g of β-cyclodextrin into 140g of water and keep stirring to make a saturated aqueous solution of β-cyclodextrin; dissolve 1g of tea tree oil in 1ml of ethanol to make a tea tree oil alcohol solution, and then add it dropwise to the saturated aqueous solution of β-cyclodextrin , stirred for 3 hours, then placed in an environment of 4°C for 24 hours, precipitated granular solids, filtered, washed the filter residue with 1ml of water and 1ml of ethanol, and dried in vacuum at 30°C to obtain tea tree oil clathrate.

Embodiment 3

[0038] Embodiment 3. Ultrasonic method prepares tea tree oil clathrate

[0039] Dissolve 1g of tea tree oil in 1ml of ethanol, dissolve 5.6g of β-cyclodextrin in 5ml of water, then mix the two solutions, sonicate in an ultrasonic cleaner for 20 minutes, filter, wash with 2ml of ethanol, and dry to obtain tea tree oil packets compound.

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Abstract

The invention discloses a tea tree oil clathrate powder inhalation and application thereof to treatment of infected pneumonia. Tea tree oil is prepared into clathrate to improve stability and reduce irritation, and water solubility is also improved to achieve suitableness for pulmonary inhalation. The tea tree oil clathrate powder inhalation is excellent in treatment effect on infected pneumonia including bacterial pneumonia and fungal pneumonia and is convenient to carry and use.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to tea tree oil clathrate powder spray and its application in treating bacterial pneumonia. Background technique [0002] Pneumonia is an inflammation of the lung parenchyma caused by a variety of pathogens and other physical and chemical factors. The main clinical manifestations are fever, cough, phlegm, chest pain, etc. In severe cases, shortness of breath, difficulty breathing, and even respiratory failure and thinking. Pneumonia seriously threatens human health. The World Health Organization survey shows that among the diseases that cause morbidity and death in the world, lower respiratory tract infection (mainly pneumonia) is listed as the third high-risk disease. Pulmonary infection has a variety of pathogens, including bacteria, viruses, mycoplasma, rickettsia, chlamydia, fungi, spirochetes, and parasites, among which bacterial infections are the most common, accounting for about ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/61A61K9/12A61K9/72A61K47/48A61P11/00A61P31/04A61P31/10
CPCA61K36/61A61K9/0075
Inventor 金义光李淼杜丽娜朱李飞刘博铭张桐桐
Owner ACADEMY OF MILITARY MEDICAL SCI
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