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Food or pet food composition containing plant extract for bone health

A technology of plant extracts and compositions applied to promote bone growth or maintain bone health, alleviate and/or treat mammalian bone diseases or maintain bone health compositions, supplements or medicines, alleviate and/or Composition for treating bone disease or maintaining bone health in mammals, manufacturing nutrients, preparing prevention, preventive field, achieving the effect of improving bone regeneration, improving activity or mobility, and reducing bone loss

Inactive Publication Date: 2005-03-30
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although these chemicals and pharmaceutical compounds are demonstrated for the treatment of bone diseases, it is still of interest to promote bone growth and prevent or reduce or treat bone / joint disease symptoms in mammals by providing safe and effective nutritional modalities

Method used

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  • Food or pet food composition containing plant extract for bone health
  • Food or pet food composition containing plant extract for bone health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Effects of Tangdi species and Dandelion species on bone formation

[0045] Extracts from the plant species Tangdi and Dandelion were examined for their potential to induce bone formation or inhibit bone resorption.

[0046] Materials and Methods

[0047] ● Preparation of extracts for screening assays:

[0048] The ground plant material is degreased with hexane and then extracted with a mixture of alcohol and water with different water percentages from 10 to 90%, preferably with 50% water. The alcohol can be methanol or ethanol to obtain the extract 1a.

[0049] The remainder of the first extract is subjected to enzymatic hydrolysis with alpha and beta glycosidases. Enzymes can be replaced by acidic conditions. This operation can be carried out under mild conditions (room temperature) or by reflux with different acid concentrations. The aqueous hydrolyzed phase is extracted with an immiscible solvent, preferably ethyl acetate, to obtain extract 2a.

[00...

Embodiment 2

[0062] Example 2: Effects of Tang Di and Dandelion on Bone Resorption

[0063] The extract prepared in Example 1 was evaluated for inhibition of IL-1 in a new bone resorption assay (10 -10 M) Ability to stimulate bone resorption. The ability of each extract to inhibit bone resorption at 10 μg / ml was evaluated.

[0064] The fruit extract of Alnus tangeri (10 μg / ml) (P.E. 734 (ethyl acetate)) inhibits IL-1-induced bone resorption in a rat calvaria assay (R.J. Murills, "In vitro bone resorption assay", vol. In Principles of Bone Biology (Academic Press, 1986, Chapter 90). This effect was reexamined in a second assay of bone resorption, the pitting assay using mixed cell cultures of rabbit bone on bovine bone slices (Tezuka K et al., 1992, Biochem. Biophys. . Res. Commun. 186(2):911-7 and Lorget F. et al., 2000, Biochem. Biophys. Res. Commun. 268(3):899-903). Absorption pits were visualized by TRAP (Tartrate Resistant Acid Phosphatase) staining, and positive cells were observe...

Embodiment 3

[0066] Example 3: Dry pet food

[0067] Feed mix consisting of about 58% by weight corn, about 5.5% by weight corn bran, about 22% by weight chicken meal, 2.5% dried chicory, about 10% dandelion leaf extract, salt, vitamins and minerals the rest.

[0068] The feed mixture is loaded into the preconditioner and moistened. The wet feed is then loaded into the extruder-cooker and gelled. The gelatinous matrix leaving the extruder is extruded through a die and extruded. The extrudate was cut into small pieces suitable for feeding dogs, dried at 110°C for about 20 minutes, and cooled to form small pieces.

[0069] The dry food has positive effects on bone and cartilage health and increases canine mobility.

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PUM

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Abstract

The present invention relates to a composition for maintenance of bone health or prevention, alleviation and / or treatment of bone disorders. It also relates to the use of the composition in the manufacture of a nutritional product, a supplement or a medicament; and a method of promoting bone growth or for the maintenance of bone health which comprises administering an effective amount of the composition.

Description

[0001] The present invention relates to compositions for maintaining bone health or preventing, alleviating and / or treating bone diseases. The invention also relates to the use of the composition in the manufacture of a nutrient, supplement or medicament; and to a method of promoting bone growth or maintaining bone health comprising administering an effective amount of the composition. Background of the invention [0002] Healthy bone requires efficient bone remodeling involving a balance between bone formation and resorption. Most bone diseases are attributed to increased bone resorption, so that the main therapeutic goal is to inhibit the increased bone resorption, and thus most of the agents developed so far are antiresorptive. For example, estrogen suppresses the production of cytokines that promote osteoclastogenesis and differentiation. SERMs (Selective Estrogen Response Modulators) are being developed to benefit bone health while reducing the risk of hormonal side effe...

Claims

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Application Information

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IPC IPC(8): A23K1/14A23K1/16A23K1/18A23L1/30A23L33/00A61K36/00A61K36/18A61K36/28A61K36/288A61K36/73A61K36/82A61K47/00A61P19/00A61P19/02A61P43/00
CPCA23K1/1646A61K36/288A23K1/1846A23K1/14A61K36/73A23L1/3002A23K10/30A23K20/10A23K50/40A23L33/105A61P19/00A61P19/02A61P19/08A61P19/10A61P43/00A61K2300/00A61K36/00
Inventor E·奥福德-卡万E·费德里希B·勒莫尔D·库尔图瓦
Owner SOC DES PROD NESTLE SA
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