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Nutritional compositions for promotion of bone growth and maintenance of bone health and methods regarding same

A composition and plant technology, applied in the field of beneficial compositions for improving bone density and bone formation, preparation of supplements or drugs, and nutritional products, which can resolve issues such as efficacy disputes

Inactive Publication Date: 2009-06-17
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, not all studies were positive for isoflavones and their efficacy remains controversial
Also, because previous studies have shown that tea drinkers have higher mean BMD than non-tea drinkers in older adults, there is some epidemiological evidence for the benefits of tea, but no interventional studies have been performed to confirm this finding

Method used

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  • Nutritional compositions for promotion of bone growth and maintenance of bone health and methods regarding same
  • Nutritional compositions for promotion of bone growth and maintenance of bone health and methods regarding same
  • Nutritional compositions for promotion of bone growth and maintenance of bone health and methods regarding same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Selected botanicals and pure compounds

[0076] Choose plants based on what you know about phenols in plants:

[0077] (i) 25 plants and soybeans were selected from the database of plants containing estrogen-like substances (Table 1A)

[0078] (ii) 9 plants + soybeans containing substances that affect the cholesterol synthesis pathway and thus have the potential to indirectly stimulate BMP-2 and bone formation (Table 1B)

[0079] (iii) Pure compounds: estradiol-17β, genistein, daidigin, 20 flavonoids, chicory compounds (sesquiterpene lactones).

[0080] Table 1A: List of plants selected from the estrogen-like plant database

[0081] name belongs to kind organ soybean Glycine Soy (Glycine max) seed calamus Calamus (Acorus) calamus

(Acorus calamus) rhizome Tang Di

(saskatoonberry) Tang Di

(Amelanchier) Oval Tang Di

(Amelanchier ovalis) fruit

mugwort

Artemisia mugwort

(Artemisia vulgaris) ...

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Abstract

Compositions and methods for maintenance of bone health or prevention, alleviation and / or treatment of bone disorders are presented. The present invention also provides the manufacture of a nutritional product, a supplement or a medicament for promoting bone growth or for the maintenance of bone health and methods regarding same. In an embodiment, the present invention provides a co mposit ion comprising an active ingredient having an effective amount of a plant or plant extract containing at least one phytochemical having the ability to induce bone morphogenic protein expression.

Description

Background technique [0001] In general terms, the present invention relates to nutritional compositions for health benefits. More specifically, the present invention relates to beneficial compositions useful, for example, in improving bone density and bone formation, and methods related thereto. [0002] Bone mass develops progressively throughout life and is regulated by genetic, mechanical, and hormonal mechanisms. Acquisition of bone mineral occurs in childhood, with peak bone mass around age 20. During this period, bone formation exceeds bone resorption. Later in life and especially around menopause or in the elderly population, bone mass and quality are impaired due to higher bone turnover with excess bone resorption, resulting in a progressive loss of bone mass, microarchitecture, architecture and strength. To maintain bone health, it is important to restore the balance between bone formation and bone resorption. Regulation of this bone remodeling process at the bone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53
CPCA23V2002/00A61K36/53A23L1/3002A23L33/105A61P19/00A61P19/02A61P19/08A61P19/10A23V2250/2136A23V2200/306A23V2250/21
Inventor E·奥福德-卡万G·威廉森D·库尔图瓦B·勒莫尔A·图什G·I·苏恩L·阿梅耶
Owner NESTEC SA
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