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Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis

a technology of vitamin and osteoporosis, which is applied in the direction of biocide, drug composition, metabolic disorder, etc., can solve the problems of high calcium intake, correlated with negative consequences with respect to bone health, and the effect of increasing overall calcium consumption on bone health has not been clearly demonstrated

Inactive Publication Date: 2011-12-22
TAM YUN KAU +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the benefit of increased overall calcium consumption on bone health has not been clearly demonstrated, and there are conflicting reports in the literature on its effectiveness.
It has also, however, been found that high levels of calcium intake may be linked to higher incidence of cardiovascular disease (Seelig et al., 2004).
This change correlates with negative consequences with respect to bone health as well as an increased risk of cardiovascular disease.
However, an excessive amount of calcium may be useless and could cause hypercalciuria and kidney stones.
The selection of appropriate salts for optimized formulations has not received appropriate attention because of reports showing that solubility of calcium salts is not related to the element's bioavailability.
However, indirect methods of measurement, such as PTH, do not provide truly accurate comparisons of calcium bioavailability.
However, zinc sulfate tended to reduce the bioavailability of iron to 11.5% and this number is significant.

Method used

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  • Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis
  • Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis
  • Formulas comprising highly soluble elements and vitamin for the prevention and amelioration of osteoporosis

Examples

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example 1

Formulations of Pearl Extracts

[0082]A pearl extract was prepared by adapting the patented method reported by Li and Li (1995). Briefly, pearls are pulverized to a size between 80 to 120 mesh. The powder is soaked in a mixture of saturated sodium chloride solution with titrated amount of acetic acid. Electrical current is applied to the mixture for several days. After dilution with water and magnetization, the mixture was filtered and precipitated. The precipitate, rich in calcium acetate, is dried and ready for consumption as a dietary supplement. A detailed list of elements present in the extract is presented on Table 1:

TABLE 1Content of Pearl ExtractElementQuantity, ppmCalcium233,000Magnesium253Zinc3281Potassium1650Manganese1170Sodium680Strontium158Molybdenum55.4Silicon38.0Selenium27.9

[0083]This extract, A1, is fortified with acetate salts of magnesium to provide Ca / Mg ratios of 0.5 / 1 (A6), 1 / 1 (A4) and 2 / 1 (A5). The major elemental content of the pearl extract and its fortified m...

example 2

Solubility of Calcium in Artificial Gastric and Intestinal Juice

[0086]The solubility of calcium in the four formulas in an artificial gastric (pH=1) and intestinal fluid (pH =7) was tested using a method developed for ICP-OES (Inductively Coupled Plasma Optical Emission Spectrometer) (PerkinElmer Optima 4300DV). Two commercial samples, Caltrate™ and calcium acetate, were also tested in parallel for comparison. The results are shown in Table 3.

[0087]Compared to Caltrate™, the solubility of calcium acetate is approximately 45 times higher in the artificial gastric juice and 26,000 times higher in the artificial intestinal juice. The solubility of the pearl extract, A1, comprising mostly calcium acetate, is similar to that of calcium acetate in the artificial gastric juice and intestinal juice (p>0.05). The solubility of calcium acetate is pH dependent; it is lower in the artificial intestinal fluid when compared to the artificial gastric juice. Magnesium has a tendency to lower the so...

example 3

Effects Of pH on the Solubility of Calcium in Different Formulations

[0091]In this example, the effects of pH (ranging from 1 to 9) on the solubility of three elements of the four pearl formulas (A1, A4, A5 and A6), a commercial product (Caltrate™) and a synthetic compound (Calcium Acetate, Ca ACE) were investigated. Solution pH was adjusted using appropriate amounts of acetic acid (AcOH), nitric acid (HNO3) or ammonium hydroxide (NH4OH). Saturated solutions were prepared by dissolving each preparation in a solution with a final pH value ranging from 1 to 9. The resultant mixtures were incubated in a water bath at 37° C. for one hour. Each sample was then filtered (with or without centrifugation) immediately, and the filtrate was diluted to an appropriate concentration for elemental analysis. The concentration of calcium, magnesium, and zinc was measured using ICP-OES. The results are shown in Tables 6-8. Statistical analysis was performed using one-way ANOVA and the P value was set ...

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Abstract

The present invention provides formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D3. The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.

Description

[0001]This application is a continuation-in-part application of U.S. application Ser. No. 12 / 845,301, filed Jul. 28, 2010, which is a continuation-in-part application of International Application PCT / IB2009 / 005042, filed Jan. 28, 2009, which claims benefit of U.S. Provisional Application No. 61 / 023,997, filed Jan. 28, 2008. The entire contents and disclosures of the preceding applications are incorporated by reference into this application.[0002]Throughout this application, various references are referred to and disclosures of these publications in their entireties are hereby incorporated by reference into this application to more fully describe the state of the art to which this invention pertains.BACKGROUND OF THE INVENTION[0003]Calcium is the major element in bones with over 99% of the body's calcium existing in bone. Adequate intake of calcium from the diet is necessary for bone growth and maintenance. Osteoporosis is a disease caused by a significant loss of bone mass leading t...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/315A61P19/08A61P19/10A61K31/593A61P3/02A23L33/00A23L33/155A61K35/02
CPCA23L1/302A23L1/303A23L1/304A23L1/3045A23V2002/00A61K31/593A61K33/06A61K33/30A61K35/02A61K45/06A61K2300/00A23V2250/7106A23V2250/1642A23V2250/1578A23V2250/161A23V2200/306A23L33/40A23L33/15A23L33/155A23L33/16A23L33/165A61K31/19A61P19/08A61P19/10A61P3/02A61P43/00A61K35/60A23L2/02A61K9/20A61K9/2095
Inventor TAM, YUN KAULIN, GE
Owner TAM YUN KAU
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