The invention discloses a screw-lifting turning type automatic water change mechanism of a water dispenser, which comprises a base, an upper support frame, an electric screw, a lifting platform, two turning guide wheels and a bottled water clamp device, wherein the base is movably connected with the upper support frame, the electric screw is arranged on the upper support frame, the two turning guide wheels are arranged on the upper support frame and are fixed by a bolt, and the bottled water clamp device is fixed on the lifting platform. The automatic water change mechanism has the advantages and effects that the bottled water clamp device is practically designed, is convenient to clamp, is exquisite and attractive in appearance and mobility, is convenient to transport, and saves household areas, in addition, the screw lifting platform can be regulated according to the height of the water dispenser, so that the universality is good.