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Gelatine/biological activity glass composite sponge dressing and preparation thereof

A bioactive glass, composite sponge technology, applied in bandages, absorbent pads, medical science and other directions, can solve problems such as unfavorable large-scale application and high price of type I collagen

Active Publication Date: 2008-11-12
上海硅健生物材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the type I collagen used is relatively expensive and has certain antigenicity, which is not conducive to large-scale application.

Method used

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  • Gelatine/biological activity glass composite sponge dressing and preparation thereof
  • Gelatine/biological activity glass composite sponge dressing and preparation thereof
  • Gelatine/biological activity glass composite sponge dressing and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Bioactive glass powder was prepared by fusion method, and analytically pure SiO 2 , Na 2 CO 3 , CaCO 3 , P 2 o 5 The raw materials are uniformly mixed in proportion, melted at 1420°C to form a homogeneous melt, then cooled, pulverized, and sieved to obtain bioactive glass powder with a particle size of 40-300 μm. The mass percentage of the glass powder consists of CaO 24.5%, SiO 2 45%, Na 2 O 24.5%, P 2 o 5 6%.

[0036] Dissolve gelatin in deionized water at a temperature of 40°C to 60°C to prepare a gelatin aqueous solution with a mass concentration of 2%; add 5% by mass of biological particles with a particle size of 100-150 μm to the gelatin solution Active glass powder, magnetically stirred for 3 hours to disperse the glass powder evenly; pour the mixed solution into the mold until the liquid layer reaches 2mm, let it stand at room temperature for 1 hour, then put it into -75℃ for 1 hour, and put the pre- The frozen gel was freeze-dried in a vacuum freez...

Embodiment 2

[0038] Preparation of bioactive glass powder by sol-gel method, using tetraethyl orthosilicate (TEOS) as SiO 2 The precursor of triethyl phosphate (TEP) as P 2 o 5 precursors. Under the catalysis of nitric acid, hydrolyze in aqueous solution, then add nitrate and mix well to form a sol. The prepared sol is aged at 60°C for 72 hours to form a gel, and then dried at 120°C for 72 hours, ball milled and sieved The obtained xerogel powder is calcined at 700° C. to obtain bioactive glass powder with a particle size of 1-40 μm. The composition of the glass powder is SiO 2 58%, CaO 33%, P 2 o 5 9%.

[0039] Dissolve gelatin in deionized water at a temperature of 40°C to 60°C to prepare a gelatin aqueous solution with a mass percent concentration of 2.5%; add 10% mass percent of the gelatin solution with a particle size of 1-40 μm The bioactive glass powder is magnetically stirred for 4 hours to disperse the glass powder evenly; pour the mixed solution into the mold, the liqui...

Embodiment 3

[0041] It is melted into a homogeneous melt at 1450°C by melting method. The mass percent of prepared bioactive glass consists of CaO 40%, SiO 2 40%, Na 2 O 8%, P 2 o 5 12%. , all the other are with embodiment 1, and result is also similar with embodiment 1.

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Abstract

The present invention relates to a gelatin / biological activity glass compounded sponge dressing and a preparation method thereof, belonging to the biomaterial field. The dressing is characterized in that a solution of a content of between 1 and 30 percent is prepared with gelatin as the raw material; the biological activity glass powder with a weight percentage of between 2 and 20 percent, prepared by the fusion method or the sol-gel method, is put into the solution; and then a mixed solution is obtained by magnetic stirring. The mixed solution is poured into a mould, the liquid layer is up to between 1 and 8 mm, the mixed solution is kept stand for 0.5 to 3 h, and then the prefreezing temperature is controlled between 20 DEG C below zero and 80 DEG C below zero; the lyophilization is controlled to be carried out at a temperature of 40 DEG C below zero and a pressure of between 5 and 10 KPa. The section of the present invention is of a double layer composite structure with a thickness of between 0.5 and 5 mm, wherein, the upper layer is a loose porous layer, and the lower layer is a dense powder layer, the thickness of the powder layer being up to between 0.1 and 2.0 mm. The double layer sponge dressing is flexible, which can be used as a parenchyma wound restoring material. Particularly, the double sponge dressing is suitable for any one of parenchyma ulcers of cervix erosions, oral ulcers, bedsores, sinuses, fat liquescency wounds, venereal disease ulcers, hemorrhoids, diabetes ulcers, etc. and the long-term erosions thereof.

Description

technical field [0001] The invention relates to a gelatin / bioactive glass composite sponge dressing for soft tissue repair and a preparation method thereof, belonging to the field of biological materials. Background technique [0002] The skin is the largest organ of the human body. If the skin is damaged in a large area, it will cause many local or even systemic problems, such as increased metabolism, excessive loss of water and protein, immune system imbalance, etc., and even life-threatening. If the wound is covered with an appropriate dressing, it can effectively reduce the severity of hypermetabolism in the patient's body, relieve pain, prevent bacterial infection, and accelerate wound healing. Among them, the treatment of long-term erosive wounds is one of the difficult problems in the medical field, and there is no very effective and simple drug treatment method. Severely ill patients can only be treated by being hospitalized for daily wound cleaning, disinfection, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/44
Inventor 常江顾卫明陈蕾
Owner 上海硅健生物材料有限公司
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