84 results about "Photon counting detector" patented technology

The invention discloses a multi-modal imaging system and method for a small animal living body. The system comprises a multi-modal fusion imaging module which is responsible for multi-modal image acquisition and primary processing; the real-time dynamic monitoring module is used for capturing bioluminescence / fluorescence signals in real time through a photon counting detector, receiving optical, nuclear medicine and magnetic resonance data, correcting motion artifacts based on a multi-scale space-time registration engine and adjusting scanning parameters through a real-time pharmacokinetic-physiological feedback mechanism; the low-radiation and biological compatible module is used for automatically optimizing the dosage of a tracer agent according to the weight of the animal, the scanning part and historical data by using a dosage prediction model; and the multi-modal data fusion module is used for performing non-rigid registration of multi-modal images based on a Transform cross-modal registration network, constructing a multi-species pharmacokinetic knowledge graph by utilizing multi-species metabolism chip data, integrating mouse, dog, primate and humanized liver chip data, and mining a cross-species metabolism rule through a graph neural network.

The present invention relates to a photon counting detector and method. The detector (20) comprises a scintillator (21) configured to convert incident gamma radiation into optical photons, a pixelated photodetector (22) configured to detect the flux of optical photons, and circuitry (23). The circuitry (23) is configured to iteratively determine, per photodetector pixel, a photon count by accumulating the number of optical photons detected by the respective photodetector pixel during an integration time, assign the photon count, per photodetector pixel, to one of multiple energy bins by use of energy thresholds separating the multiple energy bins, and dynamically adapt, per photodetector pixel or group of photodetector pixels, the energy thresholds for use in a subsequent iteration based on information on the estimated photon count of said photodetector pixel or group of photodetector pixels in the subsequent iteration.

An X-ray scanner system is provided. The system includes a photon-counting detector, a memory, and processing circuitry. The detector has a plurality of detector pixels in a channel direction. The memory stores a detector response forward model of the photon-counting detector. The detector response forward model is to be used during image reconstruction of an imaging object. The processing circuitry estimates an attenuation profile of the imaging object, determine, with respect to each of the plurality of detector pixels, a set of spatial weights, based on the estimated attenuation profile, and update, based on the determined set of spatial weights, the detector response forward model stored in the memory.

The invention belongs to the technical field of biomedical detection, and discloses a Raman spectrum analysis device for quantitative detection of hematologic tumor markers, which comprises a blood collection centrifugal unit with a self-adaptive load regulation mechanism for monitoring blood density and components in real time, centrifugal force and time parameters are automatically adjusted according to the blood density and components; the optical fiber Raman spectrometer is provided with an automatic wavelength calibration system, and an ultrafast laser pulse transmitter and a high-sensitivity photon counting detector are integrated on the optical fiber Raman spectrometer. Raman scattering signals are enhanced by adopting a quantum entanglement light source and a nonlinear optical crystal; according to the invention, the detection capability on low-concentration tumor markers can be obviously improved. Due to the improvement, the device can accurately detect the existence of the tumor marker at the early stage of cancer, and powerful support is provided for early treatment of a patient.

Methods and systems are provided for reconstructing images within a photon-counting computed tomography (PCCT) system. In an example, a method comprises, during a scan of an imaging subject, obtaining photon counts from a detector element of a photon-counting detector of the PCCT system, the photon counts partitioned into a plurality of energy bins based on an energy imparted by each photon on the detector element; encoding the photon counts at the plurality of energy bins of the detector element into a single scalar output value, the single scalar output value representing a distribution of spectral information across the energy bins; and reconstructing an image from projection data acquired via the photon-counting detector, the projection data including the single scalar output value generated at the detector element; wherein a basis material decomposition process is not performed during image reconstruction.

A vibrationally enhanced fluorescence microscopy system includes a narrowband pulsed mid-infrared laser configured to excite selected chemical bond vibrations in a sample. A continuous-wave visible laser is coaligned with the mid-infrared laser and configured to induce fluorescence from at least one fluorescent reporter bound to the sample. An external pulse generator temporally synchronizes emission of the mid-infrared pulses with emission of the visible laser. A reflective objective is arranged to deliver the mid-infrared pulses to a focal plane within the sample. A water-immersion objective is coaxially aligned with the reflective objective and arranged to collect the fluorescence from the focal plane. A photon-counting detector is coupled to receive the collected fluorescence. Control electronics are configured to output a vibrational-contrast signal derived from counts produced by the photon-counting detector.

Embodiments relate to a photon counting CT apparatus. An optimum energy band is decided according to a photographing mode, a photographing subject site, or a kind of medical equipment. A photon counting CT apparatus of an embodiment includes a photon counting detector, an acquisition unit, and a decision unit. The photon counting detector detects X-ray photons and acquires energy information. The acquisition unit acquires at least one of information about a photographing mode, information about a photographing subject site, and information about a medical equipment. The decision unit decides at least one of a condition about an energy band of data collected by the photon counting detector and a condition about an energy band of data used in reconstruction processing among data collected by the photon counting detector, based on information acquired by the acquisition unit.

A radiotherapy treatment apparatus for imaging and treating a patient, comprising: a radiotherapy system comprising a treatment radiation source configured to perform radiotherapy treatment of a patient by directing treatment radiation towards the patient, wherein the patient is located substantially within a treatment region defining a longitudinal axis, wherein the treatment radiation source is moveable with respect to the longitudinal axis to thereby enable a selection of a treatment direction in preparation for radiotherapy treatment of the patient; an imaging system comprising an imaging radiation source and a radiation detector, wherein the imaging radiation source is moveable with respect to the longitudinal axis and is arranged to direct imaging radiation towards the patient in an imaging direction, and wherein the radiation detector is arranged to measure the imaging radiation after interaction of the imaging radiation with the patient, wherein the radiation detector comprises one or more photon counting detector arrays defining a sensitive area of the radiation detector, and wherein the imaging system is configured to generate multi-spectral images of the patient based on measurements of the imaging radiation by the one or more photon counting detector arrays.

The invention provides a PCCT device and a control method thereof, which can improve the correction accuracy of a projection value even in a smaller range of the projection value. This PCCT device is provided with: a scanner that rotates, around a subject, an X-ray source that irradiates X-rays to the subject and a photon counting detector that detects X-rays that have passed through the subject for each of a plurality of energy intervals; an image generation unit that generates a tomographic image using projection data calculated from the output of the photon counting detector; and a control unit for controlling each unit, the PCCT device being characterized in that: the control unit calculates a conversion formula for converting a projection value of the subject into a transmission length using a plurality of projection values and a plurality of transmission lengths of a phantom; the plurality of projection values are acquired by rotational imaging of the phantom which is arranged so as not to overlap the center of rotation of the scanner and which has a known material, shape, and size.

This invention belongs to the field of photon counting detector manufacturing technology, specifically relating to a plasma treatment method for the crystal surface of a photon counting detector and the resulting photon counting detector. The treatment method employs a step-by-step plasma surface modification process. First, the crystal wafer surface is bombarded with plasma generated by the ionization of an inert gas. Then, a secondary bombardment is performed using plasma generated by the ionization of reactive gases such as oxygen and hydrogen. Simultaneously, key process conditions such as process gas flow rate, wafer orientation bias, processing time, cavity vacuum, radio frequency power, plasma parameters, and wafer spacing are systematically controlled. This step-by-step modification process achieves nanoscale modification of the crystal surface, effectively repairing surface damage caused by processing and forming a uniformly distributed surface modification layer. Photon counting detectors fabricated using this method can significantly reduce device leakage current, improve withstand voltage performance, optimize energy resolution, and improve photon counting rate and counting stability.

A system and method for producing a computed tomography (CT) medical image includes receiving x-rays passing through an object with a photon-counting detector system, which includes a plurality of detector pixels configured to generate a photon-counting signal in response to receiving each photon of the x-rays having passed through the object. The method also includes summing a charge associated with each photon received at a given detector pixel of the plurality of pixels to generate a charge integration signal, utilizing the charge integration signal to correct a count of the photon-counting signal for pileup-induced count losses to create a corrected photon-counting signal, and reconstructing an image of the object using the corrected photon-counting signal.

The invention belongs to the technical field of photon detection, and particularly relates to a frequency up-conversion THz wave-based multi-photon detection system and method, and the system comprises a pump light source unit, a beam combiner, a nonlinear crystal, a light splitting unit, a space photon counting detector, a light shaping device, and a controller. According to the technology, THz up-conversion signals are converted from single time domain detection to time and space domain coincidence detection, meanwhile, by means of the spatial resolving power of the multi-photon detector, when time-synchronous fluorescence is achieved, the technology can be combined with the space light gate technology to execute detection in a light gate where the signals are expected to arrive, and therefore fluorescence components are restrained. Finally, effective detection of THz up-conversion signals with spontaneous parametric up-conversion fluorescence can be realized.

The invention discloses a spectrum correction method and system for a photon counting CT detector, and relates to the technical field of medical images.The method comprises the steps that actually-measured film watching data of the detector under a target energy section is obtained; determining an energy section type of a target energy section, and distributing adaptive weights for a pre-constructed detector spectral response model and a pulse accumulation model based on the energy section type; fusing the detector spectral response model and the pulse accumulation model through the adaptive weight to realize coupling of the detector spectral response model and the pulse accumulation model; and carrying out spectrum correction on the photon counting CT detector based on the coupled detector spectrum response model and the pulse accumulation model. The method is helpful for solving the problem that the spectrum of the photon counting CT detector cannot be accurately corrected in the prior art.

The utility model relates to the field of detector chip packaging technology, specifically disclose a kind of chip packaging system of photon counting CT detector, including substrate, substrate is the middle layer of photon counting CT detector, the top of substrate is equipped with top layer sensor by connecting structure, top layer sensor is the top layer (sensor layer) of photon counting CT detector, the bottom of substrate is arranged with multiple ASIC chips by connecting structure, ASIC chip is the bottom layer of photon counting CT detector, the substrate of ASIC chip bottom (upper surface) is simultaneously as the substrate of photon counting CT detector, ASIC chip and photon counting CT detector adopt the same substrate setting, the bottom of substrate is equipped with flexible circuit board. The utility model is provided with a series of structures, quickly export the heat generated by ASIC and transfer to heat sink, realize the accurate temperature control of sensor, to low cost and process difficulty realize four sides can be spliced The photon counting detector that can realize relatively wide z direction coverage.

The application provides a multi-substance density calculation method based on X-ray energy spectrum information, S1, multi-energy spectrum projection data collection: single X-ray exposure is performed on a measured object by using a photon counting detector to obtain projection values of each pixel in each energy interval; S2, multi-substance multi-energy spectrum decomposition model establishment: a nonlinear relationship model is established for multiple substances to be decomposed; S3, substance area density solving: a target function is constructed by the difference between the actual projection values obtained in step S1 and the model calculation values in step S2, and a numerical optimization algorithm is used to solve the target function; S4, quantitative image generation: all pixels are traversed to generate the area density distribution map of each substance. The application obtains multi-energy spectrum information by using a photon counting detector, combines a nonlinear model and an optimization algorithm, realizes synchronous quantitative calculation of the densities of multiple substances, overcomes the defects of limited substance type differentiation and insufficient energy information utilization, and improves the accuracy of substance identification.

The embodiment of the invention discloses a plane X-ray imaging detection method and system. The method comprises: irradiating a plurality of regions of a human body with planar X-rays; acquiring energy projection data of a plurality of energy windows of a plurality of areas of the human body by using a photon counting detector; obtaining image information of a corresponding human body area according to the energy projection data of the plurality of energy windows; and splicing the multiple pieces of image information to obtain a detection image. According to the planar X-ray imaging detection method and system disclosed by the embodiment of the invention, abundant detection information can be conveniently and accurately obtained under the combined action of the planar X-ray and the photon counting detector.

The invention provides a novel CBCT system based on a novel line scanning bulb tube, and belongs to the technical field of X-ray medical image.The novel CBCT system comprises a sampling system and a control system.The sampling system comprises a bulb tube with a light source focus capable of conducting linear track scanning, an energy integration or photon counting detector and a movement rack system; the scanning type anode of the bulb tube can be composed of discrete array light sources and can also be composed of rotary wing anodes, and light source focuses conduct controllable, rapid and repeated scanning or movement in a motion system. Imaging is carried out through controllable light source focus linear track scanning, an imaging method similar to tomosynthesis is achieved at the position of a single bulb tube, and CBCT imaging is achieved under the condition of limited angle sampling through a rotary light source-detector rack combination.

A method for performing detector response correction in an X-ray imaging system having a photon-counting detector is disclosed. The method includes obtaining calibration data stored in a calibration data storage, which is generated during a calibration procedure performed with the X-ray imaging system at a first time. The method also includes acquiring air scan data generated through an air scan performed with the X-ray imaging system at a second time after the first time. The method further includes performing, with the X-ray imaging system, an object scan on an imaging object at a third time to generate object scan data. The third time is after the second time. The method further includes performing, using the generated object scan data, detector response correction based on the acquired air scan data and the obtained calibration data, and reconstructing, based on the performed detector response correction, an image of the imaging object.

Provided are a calibration device, a medical image capturing system, and a calibration method that can easily acquire calibration data of a photon-counting detector. A calibration device is a calibration device that is used to acquire calibration data of a photon-counting detector that outputs an electrical signal corresponding to a photon energy of incident radiation, and includes: a holding portion that holds a first base substance and a second base substance having a larger attenuation coefficient for the radiation than the first base substance; and a moving mechanism that moves the holding portion in a body axis direction of a subject irradiated with the radiation to move each of the first base substance and the second base substance between a position within an irradiation field and a position outside the irradiation field.

The application provides a flow analysis system signal processing method and device, equipment and a storage medium, and the method comprises the following steps: acquiring a detection signal of scattered light emitted by a detected particle under laser irradiation by a scattered light detector, to obtain an electric signal; analyzing the electric signal, excluding interference through a preset threshold, to obtain a starting time and an ending time of the detected particle passing through a detection area; acquiring a detection signal of fluorescence emitted by the detected particle under laser irradiation by a fluorescence detector of each fluorescence channel, to obtain a light pulse signal; recording generation conditions of the light pulse signal in the starting and ending intervals and analyzing to obtain a peak value and an area of the channel as a detection result of the channel signal. For the detection result of the photon counting detector, the method provided by the application can simply and quickly extract the area and height parameters of the event signal, can be compared with the detection and processing result of the traditional flow cytometer using an analog detector, and the method has strong compatibility.

A data processing system includes a first data processing apparatus that processes projection data from a photon counting detector, and a second data processing apparatus. The first data processing apparatus derives at least one piece of first compressed projection data by making resolution of first projection data of at least one energy band among a plurality of pieces of projection data lower than resolution of projection data of a plurality of other energy bands, and transmits the first compressed projection data and the projection data of other energy bands to the second data processing apparatus. The second data processing apparatus acquires the first compressed projection data and the projection data of the plurality of other energy bands, and derives first restored projection data by restoring the first compressed projection data based on the projection data of the plurality of other energy bands and the first compressed projection data.

According to the photon counting detector ring artifact correction method, the photon counting detector ring artifact correction device, the terminal and the medium provided by the invention, block correction and fitting error compensation are respectively performed on the photon counting detector through a high-order polynomial fitting method, so that accurate correction of the photon counting detector ring artifact is realized; meanwhile, complex modeling and time-consuming calculation are avoided, the real response laws between different detectors and the calibration plate can be accurately fitted only through a small amount of data, an accurate and reliable solution is provided for ring artifact correction, material decomposition and image reconstruction, and the method has remarkable application potential in clinical practice. The problems that a large number of annular artifacts appear after projection data reconstruction of the photon counting detector and the image quality is seriously reduced due to the fact that response laws of different detectors to spectrums are different are solved.

The invention provides a flow analysis system signal processing method and device, equipment and a storage medium, and the method comprises the following steps: obtaining a detection signal of scattered light emitted by a scattered light detector to detected particles under laser irradiation, and obtaining an electric signal; analyzing the electric signal, eliminating interference through a preset threshold value, and obtaining starting time and ending time of the detected particles passing through the detection area; acquiring a detection signal of the fluorescence detector of each fluorescence channel on the fluorescence emitted by the detected particles under the irradiation of the laser to obtain a light pulse signal; and recording the generation condition of the optical pulse signal in the starting and ending intervals, and analyzing to obtain the peak value and the area of the channel as the detection result of the channel signal. Aiming at the detection result of the photon counting detector, the method provided by the invention can simply and quickly extract the area and height parameters of the event signal, and can be similar to the detection processing result of a simulation detector adopted by a traditional flow cytometer, so that the method has relatively strong compatibility.

According to the image reconstruction method and system based on self-supervised noise reduction of the photon counting detector, the medium, the program product and the terminal provided by the invention, by constructing the noise propagation model of the photon counting CT technology in the material decomposition process, the counting noise prediction precision of the detector is improved based on the neural network; and then a self-supervised noise reduction result is optimized by using the noise propagation model, and the problem of insufficient photon counting CT training data at present is solved. According to the method, a complex modeling process and a time-consuming calculation process are not needed, response laws of different photon counting detectors can be accurately fitted only through a small amount of data, the problem of noise amplification in the material decomposition and image reconstruction process of the PCCT technology is solved, and the image quality and the processing efficiency are greatly improved. The noise reduction method based on deep learning shows extremely high practical value in the field of clinical application, is expected to provide more reliable and high-quality technical support for related work such as medical diagnosis, and promotes further development of clinical practice.

To reduce a data amount of correction data acquired by calibration in a calibration device, method and program for a photon counting type detector.SOLUTION: To acquire calibration data of a photon counting type detector composed of a plurality of detection elements for outputting a detection signal corresponding to photon energy of incident radiation. The processor is configured to acquire a plurality of detection signals output from a plurality of detection elements of the photon counting detector according to a predetermined acquisition condition, derive a difference signal indicating a difference between at least one representative detection signal representing the plurality of detection signals and the plurality of detection signals, and store the at least one representative detection signal and the difference signal as calibration data according to the acquisition condition.SELECTED DRAWING: Figure 5

Techniques for counting respective photons having energy levels within at least a first energy window and a second energy window, where the first energy window is lower than the second energy window, are presented. The techniques include: receiving a first indication of a first photon detection, the first photon detection being of a photon having an energy of at least a lower end of the first energy window; receiving a second indication of a second photon detection, the second photon detection being of a photon having an energy of at least a lower end of the second energy window; within a predetermined time interval of the receiving the first indication, communicating locally the second indication to counter logic for the first energy window, where a counter for the first energy window is not incremented; and incrementing a counter for an energy window higher than the first energy window.

A processor acquires projection data for multiple energy bins by detecting radiation transmitted through a subject using a photon-counting detector. It identifies first matching calibration data corresponding to the energy spectrum of the projection data from among multiple pieces of calibration data for material discrimination, each representing energy spectra of combinations of predefined calibration members. The processor then determines the presence or absence of a singularity in the attenuation coefficient based on differences, for each energy bin, between attenuation coefficients from the projection data and the first calibration data. If a singularity is determined to be present, the processor specifies second matching calibration data, selected from among the plurality of calibration data, based on the energy spectrum of the projection data at the higher- or lower-energy side of the singularity.

The invention relates to the technical field of detector chip packaging, and particularly discloses a chip packaging system of a photon counting CT detector, which comprises a substrate, the substrate is arranged as the middle layer of the photon counting CT detector, the top of the substrate is provided with a top layer sensor through a connecting structure, the top layer sensor is arranged as the top layer (sensor layer) of the photon counting CT detector, and the bottom layer sensor is arranged on the top layer of the photon counting CT detector. The photon counting CT detector comprises a substrate, a plurality of ASIC chips are arranged at the bottom of the substrate through connecting structures, the ASIC chips are arranged as the bottom layer of the photon counting CT detector, the substrate at the bottom (upper surface) of the ASIC chips is also used as the substrate of the photon counting CT detector, the ASIC chips and the photon counting CT detector share the same substrate, and a flexible circuit board is arranged at the bottom of the substrate. According to the photon counting detector, a series of structures are arranged, heat generated by an ASIC is rapidly conducted out and transmitted to a heat dissipation device, accurate temperature control of the sensor is achieved, and the photon counting detector which can be spliced on four sides and can achieve wide z-direction coverage is achieved with low cost and process difficulty.

1. Name of the product in this design: Photon Counting Detector Module. 2. Intended use of this design: for use in medical imaging equipment - X-ray computed tomography. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This invention discloses a dynamic control method for adaptive bias voltage in the energy region of a CZT photon counting detector, belonging to the field of radiation detection and photon counting control technology. The method acquires energy events of incident photons within a fast sliding time window and forms an energy spectrum histogram, extracting energy region composition information and flux status information for low, medium, and high energy regions. Within a slow sliding time window, it acquires count rate change information, energy peak drift information, pulse tail change information, leakage current status information, temperature status information, and current operating bias voltage information. Based on the energy region composition information, flux status information, flux change trend, and current operating bias voltage information, it matches them with a preset energy region bias voltage mapping relationship to generate candidate operating bias voltages. A polarization risk index is constructed based on count rate change, energy peak drift, pulse tail change, leakage current status, and temperature status, and a bias voltage compensation amount is generated based on the level and trend of the polarization risk index.