120 results about "Photon counting detector" patented technology

The invention discloses a multi-modal imaging system and method for a small animal living body. The system comprises a multi-modal fusion imaging module which is responsible for multi-modal image acquisition and primary processing; the real-time dynamic monitoring module is used for capturing bioluminescence / fluorescence signals in real time through a photon counting detector, receiving optical, nuclear medicine and magnetic resonance data, correcting motion artifacts based on a multi-scale space-time registration engine and adjusting scanning parameters through a real-time pharmacokinetic-physiological feedback mechanism; the low-radiation and biological compatible module is used for automatically optimizing the dosage of a tracer agent according to the weight of the animal, the scanning part and historical data by using a dosage prediction model; and the multi-modal data fusion module is used for performing non-rigid registration of multi-modal images based on a Transform cross-modal registration network, constructing a multi-species pharmacokinetic knowledge graph by utilizing multi-species metabolism chip data, integrating mouse, dog, primate and humanized liver chip data, and mining a cross-species metabolism rule through a graph neural network.

The present invention relates to a photon counting detector and method. The detector (20) comprises a scintillator (21) configured to convert incident gamma radiation into optical photons, a pixelated photodetector (22) configured to detect the flux of optical photons, and circuitry (23). The circuitry (23) is configured to iteratively determine, per photodetector pixel, a photon count by accumulating the number of optical photons detected by the respective photodetector pixel during an integration time, assign the photon count, per photodetector pixel, to one of multiple energy bins by use of energy thresholds separating the multiple energy bins, and dynamically adapt, per photodetector pixel or group of photodetector pixels, the energy thresholds for use in a subsequent iteration based on information on the estimated photon count of said photodetector pixel or group of photodetector pixels in the subsequent iteration.

The invention discloses an X-ray source tube voltage adaptive modulation CT scanning method, and relates to the technical field of tube voltage regulation, and the method comprises the following steps: S1, pre-scanning a patient; s2, drawing a scanning part contour according to a pre-scanning result; s3, selecting a tube voltage modulation optimization model; s4, determining a corresponding tube voltage modulation scheme according to the part contour and the optimization model; s5, scanning the patient by adopting a tube voltage modulation scheme, and acquiring projection data of a plurality of energy spectrums by utilizing a double-layer detector or a photon counting detector; and S6, performing dual-energy decomposition on the projection of each angle, and reconstructing to obtain a cross-sectional image of the measured part of the patient. According to the method, the tube voltage modulation scheme is obtained according to the parameter model, the image quality is effectively improved, the utilization rate of the radiation dose is improved, and a better CT image is obtained through less dose.

An X-ray scanner system is provided. The system includes a photon-counting detector, a memory, and processing circuitry. The detector has a plurality of detector pixels in a channel direction. The memory stores a detector response forward model of the photon-counting detector. The detector response forward model is to be used during image reconstruction of an imaging object. The processing circuitry estimates an attenuation profile of the imaging object, determine, with respect to each of the plurality of detector pixels, a set of spatial weights, based on the estimated attenuation profile, and update, based on the determined set of spatial weights, the detector response forward model stored in the memory.

The invention belongs to the technical field of biomedical detection, and discloses a Raman spectrum analysis device for quantitative detection of hematologic tumor markers, which comprises a blood collection centrifugal unit with a self-adaptive load regulation mechanism for monitoring blood density and components in real time, centrifugal force and time parameters are automatically adjusted according to the blood density and components; the optical fiber Raman spectrometer is provided with an automatic wavelength calibration system, and an ultrafast laser pulse transmitter and a high-sensitivity photon counting detector are integrated on the optical fiber Raman spectrometer. Raman scattering signals are enhanced by adopting a quantum entanglement light source and a nonlinear optical crystal; according to the invention, the detection capability on low-concentration tumor markers can be obviously improved. Due to the improvement, the device can accurately detect the existence of the tumor marker at the early stage of cancer, and powerful support is provided for early treatment of a patient.

The invention relates to a communication method, in particular to a time correlation photon accumulative counting communication method. According to the invention, a time correlation accumulation photon counting strategy is adopted, and the signal-to-noise ratio of the photon counting receiver can be improved through a time correlation photon accumulation method under certain background noise, so that the background noise resistance of the receiver is improved, and the communication sensitivity of the system is improved. Besides, a signal synchronization strategy of high-frequency sampling and sliding correlation is adopted, so that the problems that the initial position of the signal is not easy to position and the signal period is not easy to extract due to the randomness of signal output of the photon counting detector are effectively solved with relatively low system complexity; the synchronization and demodulation of photon counting detection output signals can be realized under the condition that the number of photons is small.

Methods and systems are provided for reconstructing images within a photon-counting computed tomography (PCCT) system. In an example, a method comprises, during a scan of an imaging subject, obtaining photon counts from a detector element of a photon-counting detector of the PCCT system, the photon counts partitioned into a plurality of energy bins based on an energy imparted by each photon on the detector element; encoding the photon counts at the plurality of energy bins of the detector element into a single scalar output value, the single scalar output value representing a distribution of spectral information across the energy bins; and reconstructing an image from projection data acquired via the photon-counting detector, the projection data including the single scalar output value generated at the detector element; wherein a basis material decomposition process is not performed during image reconstruction.

A vibrationally enhanced fluorescence microscopy system includes a narrowband pulsed mid-infrared laser configured to excite selected chemical bond vibrations in a sample. A continuous-wave visible laser is coaligned with the mid-infrared laser and configured to induce fluorescence from at least one fluorescent reporter bound to the sample. An external pulse generator temporally synchronizes emission of the mid-infrared pulses with emission of the visible laser. A reflective objective is arranged to deliver the mid-infrared pulses to a focal plane within the sample. A water-immersion objective is coaxially aligned with the reflective objective and arranged to collect the fluorescence from the focal plane. A photon-counting detector is coupled to receive the collected fluorescence. Control electronics are configured to output a vibrational-contrast signal derived from counts produced by the photon-counting detector.

Embodiments relate to a photon counting CT apparatus. An optimum energy band is decided according to a photographing mode, a photographing subject site, or a kind of medical equipment. A photon counting CT apparatus of an embodiment includes a photon counting detector, an acquisition unit, and a decision unit. The photon counting detector detects X-ray photons and acquires energy information. The acquisition unit acquires at least one of information about a photographing mode, information about a photographing subject site, and information about a medical equipment. The decision unit decides at least one of a condition about an energy band of data collected by the photon counting detector and a condition about an energy band of data used in reconstruction processing among data collected by the photon counting detector, based on information acquired by the acquisition unit.

A radiotherapy treatment apparatus for imaging and treating a patient, comprising: a radiotherapy system comprising a treatment radiation source configured to perform radiotherapy treatment of a patient by directing treatment radiation towards the patient, wherein the patient is located substantially within a treatment region defining a longitudinal axis, wherein the treatment radiation source is moveable with respect to the longitudinal axis to thereby enable a selection of a treatment direction in preparation for radiotherapy treatment of the patient; an imaging system comprising an imaging radiation source and a radiation detector, wherein the imaging radiation source is moveable with respect to the longitudinal axis and is arranged to direct imaging radiation towards the patient in an imaging direction, and wherein the radiation detector is arranged to measure the imaging radiation after interaction of the imaging radiation with the patient, wherein the radiation detector comprises one or more photon counting detector arrays defining a sensitive area of the radiation detector, and wherein the imaging system is configured to generate multi-spectral images of the patient based on measurements of the imaging radiation by the one or more photon counting detector arrays.

The invention provides a PCCT device and a control method thereof, which can improve the correction accuracy of a projection value even in a smaller range of the projection value. This PCCT device is provided with: a scanner that rotates, around a subject, an X-ray source that irradiates X-rays to the subject and a photon counting detector that detects X-rays that have passed through the subject for each of a plurality of energy intervals; an image generation unit that generates a tomographic image using projection data calculated from the output of the photon counting detector; and a control unit for controlling each unit, the PCCT device being characterized in that: the control unit calculates a conversion formula for converting a projection value of the subject into a transmission length using a plurality of projection values and a plurality of transmission lengths of a phantom; the plurality of projection values are acquired by rotational imaging of the phantom which is arranged so as not to overlap the center of rotation of the scanner and which has a known material, shape, and size.

This invention belongs to the field of photon counting detector manufacturing technology, specifically relating to a plasma treatment method for the crystal surface of a photon counting detector and the resulting photon counting detector. The treatment method employs a step-by-step plasma surface modification process. First, the crystal wafer surface is bombarded with plasma generated by the ionization of an inert gas. Then, a secondary bombardment is performed using plasma generated by the ionization of reactive gases such as oxygen and hydrogen. Simultaneously, key process conditions such as process gas flow rate, wafer orientation bias, processing time, cavity vacuum, radio frequency power, plasma parameters, and wafer spacing are systematically controlled. This step-by-step modification process achieves nanoscale modification of the crystal surface, effectively repairing surface damage caused by processing and forming a uniformly distributed surface modification layer. Photon counting detectors fabricated using this method can significantly reduce device leakage current, improve withstand voltage performance, optimize energy resolution, and improve photon counting rate and counting stability.

A system and method for producing a computed tomography (CT) medical image includes receiving x-rays passing through an object with a photon-counting detector system, which includes a plurality of detector pixels configured to generate a photon-counting signal in response to receiving each photon of the x-rays having passed through the object. The method also includes summing a charge associated with each photon received at a given detector pixel of the plurality of pixels to generate a charge integration signal, utilizing the charge integration signal to correct a count of the photon-counting signal for pileup-induced count losses to create a corrected photon-counting signal, and reconstructing an image of the object using the corrected photon-counting signal.

The image sensor comprises a photon counting detector element (10) and a first set of pulse shapers (20) for converting a signal (12) of the photon counting detector element (10) into a pulse shaper output stream (22), where the pulse (23) has at least a first pulse length (t1). A connection unit (30) combines the plurality of pulse shaper output streams (22) into at least one macro-pixel stream (32). The at least one macro-pixel stream (32) is processed by at least one monostable / non-stable circuit (40) which outputs a processed stream (42) in which the pulses (43) have a second pulse length (t2). The second pulse length (t2) is shorter than the first pulse length (t1) by a time span tPF such that a pulse-free interval (PF) at least within the time span tPF is generated after each pulse (43) in the processed stream (42).

Methods and systems are provided for compressing detector data in a computed tomography imaging system. In an example, a method for a photon counting computed tomography (PCCT) system includes, during a scan of an imaging subject, obtaining detector data from a photon counting detector of the PCCT system, the detector data comprising, for each pixel or detector element of the photon counting detector, photon counts partitioned into a plurality of energy bins based on an energy imparted by each photon on the photon counting detector, compressing the detector data into a respective set of eigenbin measurements for each pixel using one or more sets of eigenvectors identified during calibration of the PCCT system, decompressing each respective set of eigenbin measurements using the one or more sets of eigenvectors to form decompressed detector data, and reconstructing one or more images from the decompressed detector data.

The invention belongs to the technical field of photon detection, and particularly relates to a frequency up-conversion THz wave-based multi-photon detection system and method, and the system comprises a pump light source unit, a beam combiner, a nonlinear crystal, a light splitting unit, a space photon counting detector, a light shaping device, and a controller. According to the technology, THz up-conversion signals are converted from single time domain detection to time and space domain coincidence detection, meanwhile, by means of the spatial resolving power of the multi-photon detector, when time-synchronous fluorescence is achieved, the technology can be combined with the space light gate technology to execute detection in a light gate where the signals are expected to arrive, and therefore fluorescence components are restrained. Finally, effective detection of THz up-conversion signals with spontaneous parametric up-conversion fluorescence can be realized.

The invention provides a PCCT device and a control method thereof, which can improve interpolation precision related to substance discrimination and shorten processing time. This PCCT device is provided with: a scanner that rotates, around a subject, an X-ray source that irradiates X-rays to the subject and a photon counting detector that detects X-rays that have passed through the subject for each of a plurality of energy intervals; and an image generation unit that generates a tomographic image using projection data calculated from the output of the photon counting detector, the PCCT device being characterized by being further provided with: a map creation unit that creates a tomographic image using projection data calculated from the output of the photon counting detector; creating a calibration data map on the basis of the number of X-ray photons transmitted through each of a plurality of calibration phantoms having a first base material and a second base material of known material and thickness; a region division unit that divides the calibration data map into a non-linear region and a linear region; and an interpolation unit that performs a non-linear interpolation in the non-linear region and a linear interpolation in the linear region.

The invention discloses a spectrum correction method and system for a photon counting CT detector, and relates to the technical field of medical images.The method comprises the steps that actually-measured film watching data of the detector under a target energy section is obtained; determining an energy section type of a target energy section, and distributing adaptive weights for a pre-constructed detector spectral response model and a pulse accumulation model based on the energy section type; fusing the detector spectral response model and the pulse accumulation model through the adaptive weight to realize coupling of the detector spectral response model and the pulse accumulation model; and carrying out spectrum correction on the photon counting CT detector based on the coupled detector spectrum response model and the pulse accumulation model. The method is helpful for solving the problem that the spectrum of the photon counting CT detector cannot be accurately corrected in the prior art.

To provide a PCCT device capable of improving interpolation precision regarding material discrimination and shortening the processing time, and a control method for the device.SOLUTION: A PCCT device including an X-ray source irradiating a subject with X rays, a scanner turning a photon counting type detector that detects the X-rays passing through the subject for each of a plurality of energy bins around the subject, and an image generator using projection data calculated on the basis of an output of the photon counting type detector to generate a tomographic image is characterized by further having: a map generation unit generating a calibrated data map on the basis of the number of X-ray photons passing through each of a plurality of calibration phantoms having a first base material and a second base material with known materials and thickness; an area division unit dividing the calibrated data map into a non-linear area and a linear area; and an interpolation unit performing non-linear interpolation in the non-linear area and linear interpolation in the linear area.SELECTED DRAWING: Figure 4

The present invention relates to a photon counting detector comprising a scintillator (10, 20) configured to convert incident gamma radiation into optical photons; a pixelated photodetector (11, 22) configured to detect the flux of optical photons wherein the pixelated photodetector (22) is a silicon photomultiplier, SiPM, detector, wherein each photodetector pixel comprises an array of silicon avalanche photo diodes, SPADs; and circuitry (80, 90) configured to heat SPADs by applying, if dark count rate of a SPAD exceeded a dark count rate threshold, an elevated reverse bias voltage to the SPAD to force the SPAD into breakdown with current flowing through the SPAD for the time of a heating period to locally increase the temperature of the SPAD, and controlling the length of the heating period.

Aspects of the present disclosure relate to an energy-resolving photon counting detector pixel. Further aspects of the present disclosure relate to an energy-resolving photon counting detector comprising a plurality of such pixels, and to an energy-resolving photon counting system comprising the same.In accordance with an aspect of the present disclosure, a CSA base level shift detector is used for determining a shift in the CSA base level over time relative to a first level. The pixel is configured to reset the CSA in dependence of the determined CSA base level shift.

The utility model relates to the field of detector chip packaging technology, specifically disclose a kind of chip packaging system of photon counting CT detector, including substrate, substrate is the middle layer of photon counting CT detector, the top of substrate is equipped with top layer sensor by connecting structure, top layer sensor is the top layer (sensor layer) of photon counting CT detector, the bottom of substrate is arranged with multiple ASIC chips by connecting structure, ASIC chip is the bottom layer of photon counting CT detector, the substrate of ASIC chip bottom (upper surface) is simultaneously as the substrate of photon counting CT detector, ASIC chip and photon counting CT detector adopt the same substrate setting, the bottom of substrate is equipped with flexible circuit board. The utility model is provided with a series of structures, quickly export the heat generated by ASIC and transfer to heat sink, realize the accurate temperature control of sensor, to low cost and process difficulty realize four sides can be spliced The photon counting detector that can realize relatively wide z direction coverage.

The application provides a multi-substance density calculation method based on X-ray energy spectrum information, S1, multi-energy spectrum projection data collection: single X-ray exposure is performed on a measured object by using a photon counting detector to obtain projection values of each pixel in each energy interval; S2, multi-substance multi-energy spectrum decomposition model establishment: a nonlinear relationship model is established for multiple substances to be decomposed; S3, substance area density solving: a target function is constructed by the difference between the actual projection values obtained in step S1 and the model calculation values in step S2, and a numerical optimization algorithm is used to solve the target function; S4, quantitative image generation: all pixels are traversed to generate the area density distribution map of each substance. The application obtains multi-energy spectrum information by using a photon counting detector, combines a nonlinear model and an optimization algorithm, realizes synchronous quantitative calculation of the densities of multiple substances, overcomes the defects of limited substance type differentiation and insufficient energy information utilization, and improves the accuracy of substance identification.

The embodiment of the invention discloses a plane X-ray imaging detection method and system. The method comprises: irradiating a plurality of regions of a human body with planar X-rays; acquiring energy projection data of a plurality of energy windows of a plurality of areas of the human body by using a photon counting detector; obtaining image information of a corresponding human body area according to the energy projection data of the plurality of energy windows; and splicing the multiple pieces of image information to obtain a detection image. According to the planar X-ray imaging detection method and system disclosed by the embodiment of the invention, abundant detection information can be conveniently and accurately obtained under the combined action of the planar X-ray and the photon counting detector.

The invention provides a novel CBCT system based on a novel line scanning bulb tube, and belongs to the technical field of X-ray medical image.The novel CBCT system comprises a sampling system and a control system.The sampling system comprises a bulb tube with a light source focus capable of conducting linear track scanning, an energy integration or photon counting detector and a movement rack system; the scanning type anode of the bulb tube can be composed of discrete array light sources and can also be composed of rotary wing anodes, and light source focuses conduct controllable, rapid and repeated scanning or movement in a motion system. Imaging is carried out through controllable light source focus linear track scanning, an imaging method similar to tomosynthesis is achieved at the position of a single bulb tube, and CBCT imaging is achieved under the condition of limited angle sampling through a rotary light source-detector rack combination.

A method for performing detector response correction in an X-ray imaging system having a photon-counting detector is disclosed. The method includes obtaining calibration data stored in a calibration data storage, which is generated during a calibration procedure performed with the X-ray imaging system at a first time. The method also includes acquiring air scan data generated through an air scan performed with the X-ray imaging system at a second time after the first time. The method further includes performing, with the X-ray imaging system, an object scan on an imaging object at a third time to generate object scan data. The third time is after the second time. The method further includes performing, using the generated object scan data, detector response correction based on the acquired air scan data and the obtained calibration data, and reconstructing, based on the performed detector response correction, an image of the imaging object.

The present invention discloses an energy calibration composite target and a calibration method for a photon counting detector. The energy calibration composite target includes a base layer and a target material layer. A circular groove is provided at the center of the upper surface of the base layer, and the target material layer is disposed in the groove. The target material layer is formed by splicing M sector-shaped target materials sharing a common vertex into a circle, and the outer wall of the circle fits the inner wall of the groove. M≥4. Each sector-shaped target material has a single material, and different sector-shaped target materials are made of different materials, which are materials that can be excited by an X-ray light source to generate X-ray fluorescence. The area ratio of each sector-shaped target material satisfies the same fluorescence intensity detected per unit time. Based on the method of the present invention, the energy resolution of the photon counting detector for particles can be achieved, and the detector with existing energy resolution function but energy drift can be recalibrated with high precision. The laboratory light source cooperates with the electric displacement stage system to achieve remote precise control, improving safety. The composite target helps save calibration time and improve calibration efficiency.

Provided are a calibration device, a medical image capturing system, and a calibration method that can easily acquire calibration data of a photon-counting detector. A calibration device is a calibration device that is used to acquire calibration data of a photon-counting detector that outputs an electrical signal corresponding to a photon energy of incident radiation, and includes: a holding portion that holds a first base substance and a second base substance having a larger attenuation coefficient for the radiation than the first base substance; and a moving mechanism that moves the holding portion in a body axis direction of a subject irradiated with the radiation to move each of the first base substance and the second base substance between a position within an irradiation field and a position outside the irradiation field.

The application provides a flow analysis system signal processing method and device, equipment and a storage medium, and the method comprises the following steps: acquiring a detection signal of scattered light emitted by a detected particle under laser irradiation by a scattered light detector, to obtain an electric signal; analyzing the electric signal, excluding interference through a preset threshold, to obtain a starting time and an ending time of the detected particle passing through a detection area; acquiring a detection signal of fluorescence emitted by the detected particle under laser irradiation by a fluorescence detector of each fluorescence channel, to obtain a light pulse signal; recording generation conditions of the light pulse signal in the starting and ending intervals and analyzing to obtain a peak value and an area of the channel as a detection result of the channel signal. For the detection result of the photon counting detector, the method provided by the application can simply and quickly extract the area and height parameters of the event signal, can be compared with the detection and processing result of the traditional flow cytometer using an analog detector, and the method has strong compatibility.

A data processing system includes a first data processing apparatus that processes projection data from a photon counting detector, and a second data processing apparatus. The first data processing apparatus derives at least one piece of first compressed projection data by making resolution of first projection data of at least one energy band among a plurality of pieces of projection data lower than resolution of projection data of a plurality of other energy bands, and transmits the first compressed projection data and the projection data of other energy bands to the second data processing apparatus. The second data processing apparatus acquires the first compressed projection data and the projection data of the plurality of other energy bands, and derives first restored projection data by restoring the first compressed projection data based on the projection data of the plurality of other energy bands and the first compressed projection data.