212 results about "Rhinitis allergic" patented technology

The invention discloses bifidobacterium animalis and application thereof in allergic rhinitis products, and belongs to the technical field of microorganisms. The technical problem to be solved is that the existing common allergic rhinitis treatment means cannot meet the requirements of patients on safety, long-acting effect and treatment cycle. The invention provides an animal bifidobacterium subsp. Lactis Def +, and after an effective dose of animal bifidobacterium subsp. Lactis Def + is applied to a subject, the animal bifidobacterium subsp. Lactis Def + is found to be capable of remarkably relieving the allergic rhinitis symptom. Specifically, the symptoms of sneezing, dry nose and rhinocnesmus are reduced; the number of nasal septum mucosa intrinsic layer inflammation infiltration cells and nasal septum mucosa epithelium pathological changes are reduced; the IgA and IgE levels of serum are reduced; the levels of proinflammatory factors IL-4, IL-5 and IL-13 are reduced; the normal spleen index is maintained; the imbalance state of Th1 / Th2 and Th17 / Treg is effectively improved, and the body immunity is improved; a safe and long-acting scheme is provided for allergic rhinitis diseases.

The invention is suitable for the technical field of anti-allergy agents, and provides an anti-allergy agent containing compound plant anti-allergy active ingredients. Comprising 5-10 parts of a bletilla striata extract, 8-15 parts of an aloe extract, 7-12 parts of an angelica sinensis extract, 10-20 parts of a centella asiatica extract, 5-15 parts of a rosemary extract, 8-18 parts of a polygonum cuspidatum extract, 12-25 parts of a scutellaria baicalensis extract, 3-10 parts of a tea extract, 6-15 parts of a liquorice extract and 4-12 parts of a matricaria recutita extract. The preparation method of the anti-allergy agent containing the compound plant anti-allergy active ingredients comprises the following steps: step 1, extracting and concentrating in groups; step 2, compounding additional ingredients; and step 3, mixing and forming the preparation. The anti-allergy agent containing the compound plant anti-allergy active component is specifically applied to allergic rhinitis nasal spray, postoperative wound repair, pet skin anti-allergy spray, anti-allergy baby clothes treating agent, low-allergy household cleaning agent and air purification spray. And through the synergistic effect of multiple targets and multiple channels, the balanced synergism of the repairing effect and the relieving effect is realized.

The invention discloses application of lactobacillus rhamnosus in preparation of a preparation for relieving allergic rhinitis. The invention provides application of the lactobacillus rhamnosus OF44-15Ph10T or a composition containing the lactobacillus rhamnosus OF44-15Ph10T in preparation of a product with at least one of the following functions: preventing and / or treating allergic rhinitis; the symptoms of allergic rhinitis are improved or relieved; the nasal mucosa injury caused by allergic rhinitis is repaired; intestinal pathogens are inhibited; the intestinal flora balance is regulated; the lactobacillus rhamnosus OF44-15Ph10T provided by the invention provides a new direction for treating allergic rhinitis, can be applied to the fields of food, health care products and medicines, and has a wide industrial prospect.

The invention discloses application of FGL1 protein in preparation of a kit for diagnosing allergic rhinitis. It is found that the FGL1 protein content in the serum of a healthy subject and the FGL1 protein content in the serum of an allergic rhinitis patient are obviously different, and the FGL1 protein content in the serum of the allergic rhinitis patient is obviously higher than that of the healthy subject. A further diagnosis efficacy test shows that the FGL1 protein can effectively diagnose and distinguish healthy subjects and allergic rhinitis patients, the diagnosis accuracy is high, the FGL1 protein can be used for developing a kit for diagnosing allergic rhinitis, and the objectivity is obviously improved compared with an existing diagnosis method.

The invention relates to application of bifidobacterium animalis subsp. Lactis in preparation of a preparation for preventing and / or treating allergic rhinitis. The bifidobacterium animalis subsp. Lactis comprises Bifidobacterium animalis subsp. Lactis BGI-N3, the Bifidobacterium animalis subsp. Lactis BGI-N3 is preserved in the China Center for Type Culture Collection on October 17, 2022, and the preservation number of the Bifidobacterium animalis subsp. Lactis BGI-N3 is CCTCC (China Center for Type Culture Collection) NO: M20221585. Based on an allergic rhinitis animal model, the action mechanism of the animal bifidobacterium subsp. Lactis in the inflammation process is deeply analyzed, it is found that the animal bifidobacterium subsp. Lactis can effectively prevent and / or treat allergic rhinitis, and a new strategy is provided for developing a scheme for treating allergic rhinitis.

The invention relates to a pharmaceutical composition, in particular to an oral composition for treating allergic rhinitis, which takes magnolia flower and baical skullcap root as monarch drugs, dahurian angelica root, divaricate saposhnikovia root, szechuan lovage rhizome, milkvetch root and Indian buead as ministerial drugs, liquoric root as a guide and the balance as adjuvant drugs. Comprising the following components: 2-3 parts of biond magnolia flower, 2-3 parts of angelica dahurica, 3-5 parts of fructus forsythiae, 3-5 parts of fried burdock, 2-3 parts of divaricate saposhnikovia root, 3-5 parts of dandelion, 3-5 parts of astragalus membranaceus, 3-5 parts of scutellaria baicalensis, 3-5 parts of poria cocos, 3-5 parts of bighead atractylodes rhizome, 10-15 parts of coix seed, 2-3 parts of ligusticum wallichii, 2-3 parts of radix scrophulariae The traditional Chinese medicine preparation for treating wind-heat invading lung and spleen qi weakness type allergic rhinitis has the effects of dispelling wind, clearing lung, dredging nasal orifices and replenishing qi to invigorate the spleen, the symptoms of patients are relieved, and the living quality of vast child patients is improved.

The invention provides a compound probiotic composition for improving allergic rhinitis as well as a preparation method and application thereof, and belongs to the technical field of biological preparations. Comprising a composite probiotic liquid, an auxiliary agent, a humectant and a thickening agent, wherein the composite probiotic liquid is composed of a composite bacterium fermentation liquid and probiotic substances, and the composite fermentation liquid is prepared by respectively fermenting saccharomyces boulardii, two bifidobacteria, lactobacillus reuteri, lactobacillus rhamnosus and streptococcus thermophilus. According to the compound probiotic composition, growth of probiotics is promoted through different probiotics, flora balance is adjusted and immunity is improved through mutual cooperation of the different probiotics, rhinitis symptoms are improved, meanwhile, components such as centipeda minima are added to serve as auxiliaries, and the effect of improving rhinitis symptoms is achieved. And the probiotics and the compound probiotics can achieve a synergistic effect to jointly improve the symptoms of the allergic rhinitis.

The present invention relates to a nasal pharmaceutical composition comprising alcaftadine or a pharmaceutically acceptable salt and optionally one or more pharmaceutically acceptable excipients, methods of treating allergic rhinitis, allergic rhino-conjunctivitis, or symptoms thereof (such as nasal congestion) with the nasal pharmaceutical composition, and methods of preparing it.

The present invention proposes a Chinese medicine composition for treating allergic rhinitis, and a preparation method and application thereof, which belong to the field of pharmaceutical technology. Ag-graphene oxide is adsorbed on in vitro proliferated γδT cells, a Chinese medicine fermentation product obtained by fermentation and extraction of Xanthium sibiricum, Astragalus, Poria, Magnolia officinalis, and Mentha is prepared, berberine and quercetin are prepared into eutectic powder, the three are mixed and added into water, probiotics, carboxymethyl chitosan, poloxamer 407 and poloxamer 188 are added, and mixed evenly to prepare a Chinese medicine composition for treating allergic rhinitis, which has a good effect of improving allergic rhinitis, adopts a method of combining traditional Chinese and Western medicine, reduces inflammatory response, enhances the immune function of patients, improves the clinical symptoms of patients with allergic rhinitis, reduces the long-term recurrence rate, reduces the use of drugs, improves the quality of life, and reduces the risk of developing asthma, and has broad application prospects.

The invention discloses an allergic rhinitis diagnosis and allergen traceability system based on dynamic text guidance, and belongs to the technical field of intelligent medical treatment. According to the method, the problems that in the prior art, patient description is inaccurate, allergens are various in variety and have differences, and allergens are difficult to accurately determine and trace are solved, the initial situational sub-graph is verified by introducing periodic features of the patient, the causal contribution degree of the initial situational sub-graph is evaluated through a Bayesian reasoning algorithm, and a mode association result library is formed; according to the method, the crossing of the allergic rhinitis diagnosis and tracing from the traditional static judgment to the dynamic accurate inference is realized, and a personalized and scientific allergen avoidance scheme is provided for patients; through similarity retrieval, environmental information injection verification and calculation of a mode goodness-of-fit score, under the condition that patient symptoms are in multi-factor mixing, a mixed causal graph is created through a graph fusion technology, and the mode goodness-of-fit score is calculated again, so that the accuracy of obtaining an allergen traceability result in practical application is ensured.

The invention relates to the technical field of rhinitis spray preparation, in particular to a method for preparing allergic rhinitis spray from umbilical cord mesenchymal stem cell exosomes, which comprises the following steps: 1, umbilical cord treatment; 2, culturing umbilical cord mesenchymal stem cells; 3, preparing an umbilical cord mesenchymal stem cell exosome; and 4, preparing the rhinitis spray. The rhinitis spray prepared by the method disclosed by the invention is simpler and more convenient to use. The exosome, the platelet growth factor and other substances in the rhinitis spray well solve the core problems of single curative effect, large side effect, low compliance and the like in the traditional rhinitis treatment, and through the induction and repair functions of the stem cell exosome and the bactericidal ability of the antibacterial peptide, the nasal cavity environment is improved, the anaphylactic reaction is reduced, the nasal mucosa is repaired, and the rhinitis treatment effect is improved. The allergic rhinitis is expected to be fundamentally treated.

The invention provides application of tea extracellular vesicles in preparation of drugs for relieving or treating allergic respiratory diseases, and belongs to the technical field of extracellular vesicles. The invention provides application of tea extracellular vesicles in preparation of drugs for relieving or treating allergic respiratory diseases. The tea extracellular vesicles are proved to be capable of remarkably improving related symptoms of allergic respiratory diseases including allergic rhinitis, have good anti-inflammatory and immunoregulation effects, and have the application potential of being used as natural active ingredients for preparing drugs or nasal delivery preparations for treating the allergic respiratory diseases. Compared with existing hormone drugs, the tea extracellular vesicles have the advantages of being natural in source, high in safety, low in side effect and the like; moreover, the extracellular vesicles have nanoscale particle sizes, good mucous membrane permeability and bioavailability, can improve the curative effect, and are suitable for long-term intervention.

The invention belongs to the technical field of microorganisms, and particularly relates to application of bifidobacterium longum in improving immunity and preparing products for preventing, treating and / or assisting in treating rhinitis. The preservation number of the bifidobacterium longum is GDMCC No: 65969, and the bifidobacterium longum can reduce the levels of MDA and NO in serum of mice and improve the activity of SOD and CAT and the content of GSH so as to relieve oxidative stress injury; inflammatory cell infiltration of nasal mucosa is reduced, and lung tissue inflammatory mediator level and inflammation-related gene expression are reduced to inhibit inflammation; th1 / Th2 immune balance is regulated, Th2 type cytokines are reduced, Th1 type cytokines are increased, and the high-dosage effect is close to that of loratadine. The strain has a treatment effect on allergic rhinitis through multiple mechanisms, and a new choice is provided for treatment of the strain.

The invention belongs to the technical field of intelligent medical treatment, and discloses a disease monitoring and diagnosis system for allergic rhinitis and asthma syndromes treated by traditional Chinese medicines. Comprising the steps of collecting a health portrait of a patient and traditional Chinese medicine diagnosis information and performing comprehensive differentiation to obtain a traditional Chinese medicine differentiation result; analyzing the health portrait of the patient, identifying abnormal medical indexes, performing disease diagnosis based on the abnormal medical indexes, and evaluating corresponding comprehensive clinical characterization to form a western medicine diagnosis result; performing cross validation on the traditional Chinese medicine differentiation result and the western medicine diagnosis result to obtain a comprehensive diagnosis result, and dynamically generating a personalized traditional Chinese medicine prescription in combination with the obtained patient personalized factors; environment perception factors are dynamically obtained, and the personalized traditional Chinese medicine prescription is intelligently optimized; the system provides full-process intelligent support for traditional Chinese medicine diagnosis and treatment of the allergic rhinitis and asthma syndrome, so that the diagnosis and treatment quality and the treatment effect are effectively improved, and a more scientific and effective traditional Chinese medicine treatment scheme is provided for patients.

The invention belongs to the technical field of biological medicines, and particularly relates to nasal temperature-sensitive hydrogel with immunoregulation and anti-inflammatory functions as well as a preparation method and application of the nasal temperature-sensitive hydrogel. The preparation method of the nasal temperature-sensitive hydrogel with the immunoregulation and anti-inflammatory functions comprises the following steps: preparation of hydroxybutyl chitosan (HBC), preparation of levodopa-hydroxybutyl chitosan (LHBC), and preparation of CELHBC composite hydrogel. The novel temperature-sensitive hydrogel composite material of the composite hydrogel loaded with the chlorella / exosome can be used for the focus position of allergic rhinitis, and enrichment and retention of active ingredients are achieved; the chlorella is combined with the exosome, so that the inflammatory response of nasal mucosa can be relieved, the damaged nasal mucosa can be repaired, and the immune imbalance of Th1 / Th2 cells can be reversed, thereby improving the treatment effect of allergic rhinitis.

The invention provides a traditional Chinese medicine preparation for treating allergic rhinitis and a preparation method thereof, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine preparation is prepared from radix asteris, schizonepeta spike, cynanchum paniculatum, perillaseed, spina gleditsiae, cottonrose hibiscus leaf, magnolia flower, semen brassicae, cortex lycii radicis, dendrobe, oroxylum indicum and rhodomyrtus tomentosa; an in-vitro experiment shows that the traditional Chinese medicine preparation can remarkably inhibit the activity of hyaluronidase, also can inhibit the release of beta-HEX in an RBL-2H3 cell degranulation model, reduces the HIS level in a cell supernatant, and effectively improves the morphological abnormality caused by degranulation of RBL-2H3 cells; in-vivo experiments show that the traditional Chinese medicine preparation can significantly reduce behavioral scores of mice suffering from allergic rhinitis, inhibit expression of inflammatory factors TNF-alpha, serum Ig E and OVE-sIg E levels and HA concentration, reduce histopathologic changes caused by allergic rhinitis, effectively repair immune injuries of nasal mucosa of the mice and improve the curative effect of the mice. And a safe and effective new strategy is provided for the treatment of allergic rhinitis.

The invention discloses manganese-based Prussian blue-polyacrylic acid / polyvinyl alcohol hydrogel for preventing and treating allergic rhinitis. Monodisperse manganese-based Prussian blue nanoparticles synthesized by taking polyacrylic acid as a template are stably immobilized in a polyacrylic acid / polyvinyl alcohol hydrogel matrix. The obtained composite hydrogel membrane has the following prominent advantages: the composite hydrogel membrane has excellent hydrogel characteristics, including controllable membrane thickness, good tissue adhesion and air permeability; reliable biocompatibility and safety are shown; allergen permeation is effectively blocked through a physical barrier effect; prussian blue is continuously released in the slow-release degradation process, active oxygen free radicals are remarkably removed, and the powerful anti-inflammatory effect is achieved. Due to the synergistic effect of double mechanisms of protection and treatment, the material has important clinical application value and development potential in the fields of prevention and treatment of allergic rhinitis.

The invention provides pediococcus pentosaceus CQFP202426 and application of the pediococcus pentosaceus CQFP202426 in preparation of drugs for preventing or treating allergic rhinitis, and belongs to the technical field of microorganisms. The pediococcus pentosaceus CQFP202426 provided by the invention has a preservation number of CGMCC (China General Microbiological Culture Collection Center) No.29782, is preserved in the China General Microbiological Culture Collection Center on January 26, 2024, and is preserved in Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, West Beichen Road, Chaoyang District, Beijing. The strain can relieve oxidative stress injury, inhibit inflammatory response and regulate immune balance, and has a remarkable effect on prevention and treatment of allergic rhinitis.

The invention discloses a traditional Chinese medicine composition for treating allergic rhinitis, which is prepared from the following raw materials in parts by weight: 6 to 30 parts of folium mori, 6 to 30 parts of flos chrysanthemi, 1 to 9 parts of radix ginseng, 10 to 30 parts of fructus ziziphi jujubae, 3 to 10 parts of rhizoma zingiberis recens, 3 to 10 parts of liquorice root, 10 to 30 parts of radix astragali seu hedysari, 3 to 12 parts of radix angelicae sinensis, 6 to 15 parts of radix ophiopogonis, 1 to 6 parts of radix puerariae, 3 to 12 parts of radix angelicae dahuricae, 3 to 9 parts of herba menthae and 3 to 10 parts of radix platycodonis. The preparation method of the traditional Chinese medicine composition comprises the following steps: (1) respectively taking the raw materials in parts by weight, and adding water to soak for 1 hour; step 2) adding water and decocting twice, adding 400-900 parts by volume of water each time, boiling and decocting with strong fire for the first time, adding water and boiling with slow fire for the second time, and combining decoctions; and (3) adding pharmaceutically acceptable medicinal auxiliary agents according to a conventional process to prepare clinically acceptable granules, pills, tablets, powder or capsules. The traditional Chinese medicine composition has the effects of resisting allergy, inflammation and bacteria and the like, and can relieve the symptoms of nasal obstruction, running nose, sneezing and the like of allergic rhinitis patients.

The invention relates to the technical field of biological medicines, in particular to application of bifidobacterium longum subsp. Infantis in prevention and / or treatment of allergic rhinitis. Researches find that the Bifidobacterium longum subsp.infantis can improve inflammatory response, relieve symptoms of allergic rhinitis of mice, inhibit immune response caused by the allergic rhinitis, inhibit the inflammatory response caused by the allergic rhinitis and / or repair nasal mucosa injury caused by the allergic rhinitis, and the Bifidobacterium longum subsp.infantis can be used for treating the allergic rhinitis. The compound has a huge application prospect in preparation of products for preventing and / or treating allergic rhinitis.

The application discloses application of volatile oil of Citrus aurantium in preparation of a medicine for preventing and treating allergic rhinitis. The application proposes that the volatile oil of Citrus aurantium can significantly reduce the levels of mast cell factors IL-1beta and TNF-alpha, and can also significantly reduce the levels of inflammatory factors IL-13 and IL-4 in mice, reduce inflammatory cell infiltration, and reduce eosinophilic granulocyte increase and gland hyperplasia. The application proposes that the volatile oil of Citrus aurantium has great potential as a medicinal and edible raw material for treating allergic rhinitis. The application also proposes that the volatile oil of Citrus aurantium can significantly improve symptoms such as sneezing, runny nose, and nasal itching of mice caused by allergic rhinitis, and the symptoms seriously affect the life of patients.

The invention relates to application of plant lactobacillus in preparation of a preparation for preventing and / or treating allergic rhinitis. The plant lactobacillus comprises Lactobacillus plantarum BGI-N6, the Lactobacillus plantarum BGI-N6 is preserved in the China Center for Type Culture Collection on June 5, 2023, and the preservation number of the Lactobacillus plantarum BGI-N6 is CCTCC (China Center for Type Culture Collection) NO: M2023948. Based on an allergic rhinitis animal model, the action mechanism of the plant lactobacillus in the inflammation process is deeply analyzed, it is found that the plant lactobacillus can effectively prevent and / or treat the allergic rhinitis, and a new strategy is provided for developing a scheme for treating the allergic rhinitis.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a pharmaceutical composition for treating rhinitis and a preparation method and application thereof. The invention provides a pharmaceutical composition for treating rhinitis. The pharmaceutical composition is prepared from the following components in parts by mass: 12-15 parts of astragalus membranaceus, 9-12 parts of codonopsis pilosula, 9-12 parts of houttuynia cordata, 6-9 parts of divaricate saposhnikovia root, 9-12 parts of bighead atractylodes rhizome, 6-9 parts of radix bupleuri, 6-9 parts of ginger processed pinellia, 6-9 parts of fructus forsythiae, 6-9 parts of radix angelicae, 6-9 parts of fried semen armeniacae amarae, 6-9 parts of cocklebur fruit, 6-9 parts of isatis root, 6-9 parts of pogostemon cablin, 3-6 parts of rhodiola rosea, 2-4 parts of schizonepeta, 3-6 parts of dried ginger, 3-5 parts of Chinese date and 3-6 parts of liquorice. The composition provided by the invention is effective for both allergic rhinitis and chronic sinusitis, can relieve acute symptoms and improve chronic inflammation, and overcomes the defect of insufficient pertinence of the existing traditional Chinese medicine compound.

The application relates to the technical field of Chinese medicine preparation, in particular to a medicine composition for treating allergic rhinitis and a preparation method and application thereof, and the preparation method of the medicine composition for treating allergic rhinitis is as follows: step 1, preparing mixed Chinese herbal medicine A and mixed Chinese herbal medicine B; step 2, subjecting the mixed Chinese herbal medicine A to enzymatic treatment to obtain an enzymatic product; step 3, adding a synergistic agent and inoculating compound microorganisms into the enzymatic product, carrying out aerobic fermentation, adding the mixed Chinese herbal medicine B, and then carrying out anaerobic fermentation to obtain the medicine composition for treating allergic rhinitis. The medicine composition prepared in the application can not only effectively relieve the behavior symptoms such as scratching nose, sneezing and running nose of allergic rhinitis mice, inhibit allergic IgE immune response, but also efficiently relieve the symptoms of allergic rhinitis patients, and has good treatment effect.

This invention belongs to the field of anti-allergy functional food technology, specifically relating to an anti-allergy composition containing inactivated Akkermansia myxophilus. Existing anti-allergy drugs have side effects. The composition of this invention contains inactivated Akkermansia myxophilus, quercetin, vitamin C, and zinc. This invention can improve allergic rhinitis, alleviate eczema symptoms, and improve allergic constitution by regulating immune balance and inhibiting histamine release. The composition of this invention is stable at room temperature and can be formulated into powder or chewable tablets.

Administration of pentadecanoylcarnitine or pentadecanoic acid is provided for prevention, management or treatment of aggression, allergies, allergic rhinitis, Alzheimer's disease, anxiety and anxiety disorders, amyotrophic lateral sclerosis, arthritis, asthma, atherosclerosis, attention-deficit hyperactivity disorder, bipoloar disorder, brain damage, cancer, cardiovascular disease, cholestatic pruritis, depression, chronic obstructive pulmonary disease (COPD), cocaine abuse, cough, dermatitis, depression, drug-seeking behavior, gastrointestinal disorders, facial erythema associated with rosacea, glaucoma, hepatic diseases, hyperactive bladder, hypersensitivity disorders, hypertension, impulsivity, inflammation, mental disorders and conditions, metabolic disorders, migraines, nasal and sinus congestion, nausea, neuropathic pain with and symptoms of multiple sclerosis, neurological and neuropsychiatric disorders, obesity, obsessive-compulsive disorders, opioid-induced respiratory depression, osteoarthritis, pain, Parkinson disease, pathological gambling, peptic ulcers, schizophrenia, sleep disorders, spinal cord injury, tardive dyskinesia, tics and behavioral problems with Tourette's syndrome; as well as for supporting appetite, cardiovascular health, hematologic health, memory, metabolic health, mood, prolonged REM sleep, renal health, sexuality, sociability and metabolic, hematological, renal, and weight loss.

The invention discloses a construction method and application of a machin allergic rhinitis animal model, and belongs to the field of disease animal model construction. According to the method, house dust mites are firstly used for sensitization, then 10% hydrogen peroxide and house dust mites are combined for excitation modeling, the 10% hydrogen peroxide destroys nasal mucosa and accelerates occurrence of allergic rhinitis, and the monkeys with allergic rhinitis are obtained after 13 periods of modeling. According to the method, the animal model which is highly similar to human allergic rhinitis in behavior, inflammatory symptom and phenotype is successfully constructed. The model provides guarantee for observing nasal symptoms and rhinitis behaviors of allergic rhinitis, inducing an organism to generate allergy-related immune response, establishing a sensitization basis, simulating a pathogenesis process, researching pathogenesis of allergic rhinitis, screening allergic rhinitis drugs and the like.

The invention provides a traditional Chinese medicine delivery system of temperature-sensitive gel for allergic rhinitis based on a fructus xanthii formula, belongs to the technical field of pharmaceutical preparations, and solves the technical problems that the existing allergic rhinitis medicines are mainly hormone, have repeated effects and the like. Comprising the following preparation steps: S1, initially preparing a traditional Chinese medicine formula of the cocklebur fruit powder for treating rhinitis; s2, performing raw material level network pharmacology prediction; s3, trial production of a raw material grade temperature-sensitive gel product; s4, carrying out raw material grade experiment testing; s5, carrying out pharmacological prediction on the monomer-level network; s6, carrying out preliminary trial production on the monomer-grade temperature-sensitive gel product; s7, carrying out monomer-level preliminary experiment testing; s8, upgrading the formula; s9, carrying out trial production on the monomer-grade temperature-sensitive gel product again; and S10, carrying out experimental test on the monomer level again to confirm the most effective traditional Chinese medicine formula. According to the invention, a set of closed-loop iteration system of clinical experience-network pharmacology prediction-response surface process optimization-multi-level pharmacodynamic verification is constructed, and a traditional Chinese medicine delivery product which is controllable in quality, clear in mechanism and excellent in curative effect and is used for effectively treating allergic rhinitis can be prepared.

The invention relates to the technical field of scheme recommendation, in particular to an allergic rhinitis treatment scheme recommendation method based on artificial intelligence. According to the method, individual feature data of a target individual and individual feature data of historical individuals are merged into a unified data set; determining feature similarity according to the individual feature data of any two individuals in the unified data set; dividing a plurality of reference groups based on the feature similarity, and identifying a target reference group to which the target individual belongs; determining a health state deviation degree based on the clinical manifestation data of the target individual on a plurality of time nodes before intervention, and arranging the health state deviation degree according to time to form health state time sequence data; determining a comprehensive similarity according to the health state time sequence data of the target individual and each historical individual in the target reference group; screening out a high-similarity historical individual set according to the comprehensive similarity; and the candidate treatment schemes are generated based on the historical treatment schemes associated with the set, so that the accuracy of treatment scheme recommendation is improved.

The application discloses CpG-containing oligodeoxynucleotide (ODN) with the function of regulating the body's immune capacity and application thereof. The oligodeoxynucleotide in the application is different from the design concept of traditional A-type CpG ODN in sequence and structure, embodies the complex drug-making rule and overcomes the problem of traditional A-type CPG in drug-making. The oligodeoxynucleotide has excellent activity of regulating the body's immune function in vitro and in vivo, can stimulate the production of I, II and III type interferons, regulates the Th1 type immune response, and inhibits the Th2 type and Th17 type inflammatory response. Therefore, the oligodeoxynucleotide can prevent and treat allergic diseases caused by Th2 type immune response, including allergic rhinitis, atopic dermatitis, asthma, chronic obstructive pulmonary disease, eosinophil and Th17 related diseases, can prevent and treat the infection and spread of respiratory or non-respiratory pathogenic microorganisms including viruses, bacteria, fungi and parasites, can improve the immune level of the elderly and immunodeficient population, can convert "cold tumor" into "hot tumor", improve the effect of cancer immunotherapy, can prevent and treat central nervous system diseases related to immune dysfunction such as Alzheimer's disease, and can be applied to other diseases related to immune dysfunction.