Preparation method of hydrophobically modified sodium alginate

Abstract

A preparation method of hydrophobically modified sodium alginate gel belongs to the technical field of biomedical materials. The invention prepares a star polymer which contains inorganic matter and hydrophobic polymers; the prepared polymer is ultrasonically dispersed into a sodium alginate solution by ultrasonic dispersion technology; and a calcium alginate hybrid gel with both hydrophobicity and hydrophilicity is prepared by a dropping liquid method. A hydrophobic drug of ibuprofen has a high embedding rate of up to above 90% in the gel, and has a good sustained release effect with a drug release amount of the first 2 hours being reduced by nearly 45%; the problem is overcome that since sodium alginate has strong hydrophilicity and the loading amount for hydrophobic drugs is less, burst release is easy to occur in an early stage of drug release. The drug-loaded microsphere of the invention is convenient for preparation, controllable in particle size (about 1 mm), good in biocompatibility, has no toxicity to human body, and has potential application value for being used as a drug carrier.

Description

technical field [0001] A preparation method of hydrophobically modified sodium alginate gel belongs to the technical field of biomedical materials. Background technique [0002] Sodium alginate is a high-molecular compound extracted from brown algae, with abundant raw material sources, good biocompatibility, no immunogenicity to biological tissues, biodegradation, and non-toxic degradation products; compared with other polymers, Low price, abundant sources, better hydrophilicity, easy cell adsorption, and easy penetration of nutrients; compared with other natural polymers, and divalent calcium cations under mild conditions can form compounds that meet various performance requirements. Gel, so it has a wide range of applications in the food industry, the cosmetic industry and the pharmaceutical industry. Among them, in the pharmaceutical industry, sodium alginate has been widely used as a drug carrier for many years in the preparation of various drug delivery systems such as...

AI Technical Summary

Problems solved by technology

[0003] However, many excellent hydrophobic drugs such as ibuprofen, doxorubicin, itraconazole, etc. are quite good drugs in the treatment of diseases, but they have low solubility in sodium alginate gel and low availability , the application is limited

In order to improve the availability, people have adopted a variety of research methods, such as: increasing the total specific surface area by grinding to increase solubility, particle crystallization, spray drying, etc., but these methods have their own shortcomings, such as poor dispersion and poor stability. , particle size distribution is too wide, etc.

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