Biological adhesive as well as preparation method and application thereof

A bio-adhesive and initiator technology, used in applications, adhesives, surgical adhesives, etc., can solve the problems of no adhesive effect and insufficient gel consistency, and can expand application methods, avoid using procedures, and expand Application-wide effects

Inactive Publication Date: 2017-11-24
杭州易敏生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In some studies, in order to improve the reactivity and viscosity of polysaccharides, some active groups are added to linear polysaccharides, but because the density of active groups is not high enough, the gel consistency formed is not high enough and does not have an adhesive effect

Method used

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  • Biological adhesive as well as preparation method and application thereof
  • Biological adhesive as well as preparation method and application thereof
  • Biological adhesive as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0043] The preparation method of above-mentioned bioadhesive, comprises the steps:

[0044] Step 1, component a is formulated into an aqueous solution;

[0045] Step 2, component b is formulated into an aqueous solution;

[0046] Step 3. When in use, the aqueous solution of step 1 and the aqueous solution of step 2 are mixed by physical methods, and the physical methods include spraying, coating, injection, vortex, shaking or magnetic stirring.

[0047] The adhesive also includes component c: osmotic pressure regulator or / and component d: preservative or / and component e: essence, wherein the osmotic pressure regulator includes sodium chloride, potassium chloride, One or more of calcium chloride.

[0048] The preparation method of above-mentioned bioadhesive, comprises the steps:

[0049] Step 1, preparing component a, part of component c or / and part of component d or / and part of component e into an aqueous solution;

[0050] Step 2, preparing component b, remaining compone...

Embodiment 1

[0054] Preparation of Star Polymers Containing a Large Number of Amino Functionalization at the Terminals

[0055] Step 1: Using the principle of Michael addition, 60 parts by mass of acrylate and 10 to 20 parts by mass of ethylenediamine are dissolved in 100 parts by mass of methanol at -7 to -3°C. After fully reacting at 25°C for 24 hours, unreacted chemical substances and methanol were removed by continuous rotary evaporation to obtain an intermediate product A (tetramethyl ester polyamide). The molecular terminal of the intermediate product A contained 4 methyl ester groups.

[0056] Step 2: Using the principle of transesterification, mix and dissolve 20 parts by mass of intermediate product A and 80-160 parts by mass of ethylenediamine at -7-3°C in 200 parts by mass of methanol, and react at 18-25°C After 48 hours, unreacted chemical substances and methanol were removed by continuous rotary evaporation to obtain a star compound G-4 (tetraaminopolyamidoamine) with 4 amino ...

Embodiment 2

[0059] Preparation of Four-armed Polyethylene Glycol Star Polymer with Polyamino-modified Terminals

[0060] Dissolve 10 parts by mass (MW=2000) of four-arm polyethylene glycol acrylate (Xiamen Sinobanger, 4-armPEG-AA), 2 to 6 parts by mass of ethylenediamine at -7 to -3°C In 100 parts by mass of DMF solvent, react at 18-25°C for 24 hours, purify and remove unreacted chemical substances and solvents, and obtain aminated four-armed polyethylene glycol with 8 amino groups at the end, ie I-8.

[0061] Similarly, using the principle of Michael addition and transesterification in Example 1, changing the input amount, ratio, and reaction time of raw materials, it is possible to obtain aminated tetramethylammonium chloride with 16, 32 or more amino groups at the end. Arm polyethylene glycol star polymer, namely I-16, I-32....

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Abstract

The invention discloses a biological adhesive which comprises a component a, and a component b, wherein the component a is a functional star polymer or/and a functional comb-like polymer, the functional star polymer is provided with one or more active groups, and the functional comb-like polymer is provided with one or more active groups; the component b is a functional polysaccharide which is provided with one or more active groups; and chemical reactions can be carried out between the active groups of the component a and the active groups of the component b so as to form novel chemical bonds. The invention further discloses a preparation method and application of the biological adhesive. The biological adhesive disclosed by the invention is a biocompatible adhesive (glue) formed by rapidly reacting the functional star polymer or/and comb-like polymer with lots of active groups and the functional polysaccharide. The adhesive based on the star polymer or/and comb-like polymer has a star or/and comb structure and has lots of active reactive groups, so that the gel forming reaction is fast, and the adhesive is reacted with tissues so as to realize an adhesive effect.

Description

technical field [0001] The invention relates to the technical field of adhesives, in particular to a bioadhesive and its preparation method and application. Background technique [0002] Traditional surgical operations, plastic surgery, etc. cannot get rid of the use of instruments and sutures. However, the suture method is difficult and time-consuming to operate, and it brings a lot of inconvenience to remove the stitches and change the dressing. The wound is prone to infection and suppuration, and local hyperplasia occurs. . In recent decades, in order to reduce the complexity of surgery and the trauma to patients, medical adhesives have been developed rapidly and widely used. [0003] Medical adhesives refer to medical materials that can be polymerized in the body to quickly bond between tissues or between tissues and non-tissues, and can play a certain role in hemostasis and sealing. According to different material properties, medical adhesives can be divided into chem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09J187/00C08G81/00A61L24/04A61L24/00
CPCA61L24/001A61L24/046C08G81/00C09J187/005C08L87/005
Inventor 文学军吴建华姚江平
Owner 杭州易敏生物医药科技有限公司
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