Multi-block polyurethane shape memory high molecule material and preparation method thereof

A technology of polymer materials and polyurethane, applied in the field of shape memory polymer materials and its preparation, can solve the problems of slow degradation of PCL and achieve good biodegradability, high mechanical strength and flexibility

Inactive Publication Date: 2009-04-01
CHONGQING UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the slow degradation rate of PCL, the clinical application value of this smart suture needs to be further verified.

Method used

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  • Multi-block polyurethane shape memory high molecule material and preparation method thereof
  • Multi-block polyurethane shape memory high molecule material and preparation method thereof
  • Multi-block polyurethane shape memory high molecule material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Weigh 5.000 g (0.03472 mol) of D, L-lactide (LA) which has been distilled and recrystallized, and 1.25 mL (density: 1.266 g / mL, 0.01551mol), chloroform solution of stannous octoate (T-9) 16.1uL (3.4×10 -6 mol), ethylene glycol 32uL, mix well, and vacuumize for 10-20min. After sealing, place it in a constant temperature oil bath at 130°C for 16 hours. The reaction product was dissolved in acetone, purified with n-hexane, and dried under vacuum at room temperature to obtain 3.8 g of hydroxyl-terminated polymer HO-P(LA-co-PDO)-OH. The number average molecular weight measured by terminal hydroxyl analysis method is 2100, T g = 20.54°C.

Embodiment 2

[0033] Weigh 5.000 g (0.03472 mol) of D, L-lactide (LA) which has been distilled and recrystallized, and 1.25 mL (density: 1.266 g / mL, 0.01551mol), chloroform solution of stannous octoate (T-9) 16.1uL (3.4×10 -6 mol), diethanolamine 55uL, mix thoroughly and evenly, and vacuumize for 10-20min. After sealing, place it in a constant temperature oil bath at 130°C for 16 hours. The reaction product was dissolved in acetone, purified with n-hexane, and dried under vacuum at room temperature to obtain 3.6 g of hydroxyl-terminated polymer HO-P(LA-co-PDO)-OH. The number average molecular weight measured by terminal hydroxyl analysis method is 2400, T g = 21.98°C.

Embodiment 3

[0035] Weigh 5.000 g (0.03472 mol) of distilled and recrystallized D, L-lactide (LA), 0.40 mL (density: 1.266 g / mL, 0.00496mol), chloroform solution of stannous octoate (T-9) 12.8uL (2.7×10 -6 mol), ethylene glycol 32uL, mix well, and vacuumize for 10-20min. After sealing, place it in a constant temperature oil bath at 140°C for 24 hours. The reaction product was dissolved in acetone, purified with n-hexane, and dried under vacuum at room temperature to obtain 3.9 g of hydroxyl-terminated polymer HO-P(LA-co-PDO)-OH. The number average molecular weight measured by terminal hydroxyl analysis method is 19970, T g = 39.59°C.

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Abstract

The invention provides a multi-block polyurethane shape memory polymer material based on lactide and 1, 4-dioxegy cyclohexanone. The polymer material takes hydroxyl terminated poly (lactide-co-1, 4-dioxegy cyclohexanone) as a soft block; a PUU chain segment or uramido chain segment product which is formed by vulcabond and bifunctional micromolecules containing active hydrogen is chosen as a hard block. The temperature of the shape memory is within 20-55 DEG C. The invention further provides the preparation method of the material. The shape memory polymer material based on lactide and 1, 4-dioxegy cyclohexanone provided by the invention integrates good odegradability, biocompatibility, high mechanical strength, flexility and the shape memory performance together. The deformation temperature of the polymer material can be adjusted to be close to human body temperature; therefore, the polymer material is applied to surgical operations or medical appliance implantation materials.

Description

Technical field: [0001] The invention relates to a biodegradable shape memory polymer material and a preparation method thereof, belonging to the field of biomedical polymer materials. Background technique: [0002] Shape memory refers to the phenomenon that a product with a certain initial state can automatically return to its original shape under a specific external stimulus after being deformed and shaped. The currently researched shape memory materials mainly include shape memory alloys, ceramics and polymer materials. Among them, shape memory polymer materials can be divided into three categories: temperature-sensitive, light-sensitive and ion-sensitive. For temperature-sensitive shape-memory polymer materials, their shape-memory performance is often determined by the composition, structure and processing technology of the material. Shape memory polymer materials usually contain soft segments and hard segments and have a two-phase separation structure of soft and hard...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G18/66C08G18/42C08G18/10
Inventor 罗彦凤梁志清王远亮王素军黄美娜刘钊李玉艳
Owner CHONGQING UNIV
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