The invention discloses a making method of antibiotic product of surface through physical gas-phase sediment technique, which comprises the following steps: plating antibiotic target or evaporating material on the base surface to form antibiotic coater through physical gas-phase sediment technique; allocating the antibiotic target or evaporated material with one or more component of Ti, Zn, Ca, Si, Mg, Zr, Cd, As, Sb, Se, Ce, Re, Cu, Ag, Pb, Hg, Co, Ni, Al, Fe and their oxide, sulfate, nitride and carbonate; aerating O2, N2, NH3, CH4, C2H6 or H2S as reacting gas.