Vital cell preparations containing lactic acid bacterium as the ative ingredient and food containing lactic acid

一种乳酸杆菌、活性成分的技术，应用在含有效成分的医用配制品、乳杆菌、食品制备中使用的细菌等方向，能够解决没有公开消除或者抑制牙周疾病和龋齿的数据等问题

Inactive Publication Date: 2005-06-08
KOIKEYA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the above-mentioned literature on the prevention and treatment of periodontal disease and halitosis using Lactobacillus, there is no disclosure at all of the data on the elimination or inhibition of periodontal disease and dental caries obtained using the in vivo system of humans or model animals, or about data on the viability of live bacterial preparations or foodstuffs, and the flavor and physicochemical characteristics of such live bacterial preparations or foodstuffs containing Lactobacillus

Method used

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  • Vital cell preparations containing lactic acid bacterium as the ative ingredient and food containing lactic acid
  • Vital cell preparations containing lactic acid bacterium as the ative ingredient and food containing lactic acid
  • Vital cell preparations containing lactic acid bacterium as the ative ingredient and food containing lactic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0165] Example 1: Preparation of dried cells of Lactobacillus salivarius TI 2711 strain

[0166] Lactobacillus salivarius TI 2711 strain was inoculated into Briggs fresh broth containing 0.3% calcium carbonate, and statically cultured at 37°C for 18 hours. After the cultivation, the culture was centrifuged at 7,000 rpm for 15 minutes to obtain cells with a concentration of 1 / 100 volume.

[0167] Then, a dispersion medium containing 5% (weight) sodium glutamate, 5% (weight) soluble starch, 5% (weight) sucrose and concentrated cells were mixed in equal amounts, and the pH value of the mixture was adjusted to 7.0. Freeze at 40°C or lower and lyophilize. The obtained freeze-dried cells are passed through a 60-mesh sieve to prepare a powder to obtain the lactobacillus powder of the present invention. As for the preservation stability of the bacteria of the present invention, even when the Lactobacillus powder was stored at room temperature (24°C) for 10 months under closed conditions, ...

Embodiment 2

[0168] Example 2: Preparation of medicinal live bacterial preparations (tablets)

[0169] According to the 12th revision of the Japanese Pharmacopoeia guidelines, the general rules for pharmaceutical preparations, the provisions of "tablets", 2 grams of Lactobacillus salivarius TI 2711 strain dried cell powder prepared in Example 1 (cell number: 5× 109 CFU / g), 161 g of lactose (Japanese Pharmacopoeia), 116 g of starch (Japanese Pharmacopoeia), 20 g of binder polyvinylpyrrolidone (Japanese Pharmacopoeia) and 0.8 g of magnesium stearate (Japanese Pharmacopoeia) as a lubricant They were brought together and mixed uniformly, and the mixture was compressed into a mold with a tablet manufacturing equipment to obtain 290 grams of ordinary tablets (300 mg per tablet).

Embodiment 3

[0170] Example 3: Preparation of food containing Lactobacillus (sugar-flavored tablets)

[0171] With reference to the Japanese Pharmacopoeia Guidelines for the 12th revision, the general rules for pharmaceutical preparations and the provisions of "tablets", 0.7 g of the dried cell powder of Lactobacillus salivarius TI 2711 strain prepared in Example 1 (cell number: 5× 10 9 CFU / g), 47 g of erythritol, 47 g of sorbitol, 2.5 g of 1-menthol, 1.5 g of flavoring agent (lime) and 1.3 g of fatty acid sugar esters as a food additive in Japan as a lubricant, Add them together and mix them uniformly, and compress the mixture into a mold with a tablet manufacturing equipment to obtain 95 grams of ordinary tablets (300 mg per tablet).

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Abstract

Disclosed vital cell preparations or lactic acid bacterium-containing foods containing a lactic acid bacterium Lactobacillus salivarius as the active ingredient. These preparations and foods make it possible to prevent the occurrence, recurrence or recrudescence of periodontal diseases and / or caries caused by bacteria participating in periodontal diseases and / or caries and to normalize oral flora, thereby prevent mouth odor and maintain the saliva within a physiologically normal pH range.

Description

Technical field [0001] The present invention relates to a medicine (live bacterial preparation) containing Lactobacillus as an active ingredient for thorough oral care, for the prevention and treatment of gingivitis, periodontitis, periodontal disease, dental caries and bad breath, and to a medicine containing lactic acid Bacillus foods and their applications. Background technique [0002] According to the Japanese Ministry of Health, Labor and Welfare (Japanese Ministry of Health, Labor and Welfare) survey report, the number of patients suffering from periodontal disease accounted for the total national population. According to the survey, it rose from 18.2% in 1975 to 61.8% in 1993 and 61.8% in 1999. 72.9%. Since then, the number has grown steadily, and the estimated number of patients has reached or even 90 million. The current situation is that a large amount of expenditure is invested in the dental field from the viewpoint of medical economics. [0003] Therefore, in 1988, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23G3/00A23G3/36A23G4/00A23G4/12A23L1/28A23L1/30A23L31/00A61K35/74A61K35/747A61P1/02C12N1/14C12R1/225
CPCA23G3/366A23G4/123A61K35/747A23L33/135A61P1/02A61P31/00A61P43/00C12R2001/225C12N1/205A23V2400/179
Inventor 古贺泰裕
Owner KOIKEYA
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